Assessment of Structural Intolerance and Durability
General Structure Information 1g9l PABPC1 solution structure of the pabc domain of human poly(a) binding protein -1.0Å AUTH G.KOZLOV,J.F.TREMPE,K.KHALEGHPOUR,A.KAHVEJIAN,AUTH 2 I.EKIEL,K.GEHRINGTITL STRUCTURE AND FUNCTION OF THE C-TERMINAL PABCTITL 2 DOMAIN OF HUMAN POLY(A)-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 98 4409 2001REFN ISSN 0027-8424PMID 11287632DOI 10.1073/PNAS.071024998 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4g84 HARS crystal structure of human hisrs 2.4Å AUTH Z.XU,Z.WEI,J.J.ZHOU,F.YE,W.S.LO,F.WANG,C.F.LAU,J.WU,AUTH 2 L.A.NANGLE,K.P.CHIANG,X.L.YANG,M.ZHANG,P.SCHIMMELTITL INTERNALLY DELETED HUMAN TRNA SYNTHETASE SUGGESTSTITL 2 EVOLUTIONARY PRESSURE FOR REPURPOSING.REF STRUCTURE V. 20 1470 2012REFN ISSN 0969-2126PMID 22958643DOI 10.1016/J.STR.2012.08.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4eeg B4GALT1 crystal structure of human m340h-beta-1,4-galactosyltransferase-1 (m340h-b4gal-t1) in complex with glcnac-beta1,6-gal-beta 2.2Å AUTH B.RAMAKRISHNAN,E.BOEGGEMAN,P.K.QASBATITL BINDING OF N-ACETYLGLUCOSAMINE (GLCNAC) BETA 1-6-BRANCHEDTITL 2 OLIGOSACCHARIDE ACCEPTORS TO BETA 4-GALACTOSYLTRANSFERASE ITITL 3 REVEALS A NEW LIGAND BINDING MODE.REF J.BIOL.CHEM. V. 287 28666 2012REFN ISSN 0021-9258PMID 22740701DOI 10.1074/JBC.M112.373514 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2gk2 CEACAM1 crystal structure of the n terminal domain of human ceacam1 2.2Å AUTH A.FEDAROVICH,J.TOMBERG,R.A.NICHOLAS,C.DAVIESTITL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN CEACAM1: BINDINGTITL 2 TARGET OF THE OPACITY PROTEINS DURING INVASION OF NEISSERIATITL 3 MENINGITIDIS AND N. GONORRHOEAE.REF ACTA CRYSTALLOGR.,SECT.D V. 62 971 2006REFN ISSN 0907-4449PMID 16929097DOI 10.1107/S0907444906020737 Variant Set Distributions […]
General Structure Information 4gdx GGT1 crystal structure of human gamma-glutamyl transpeptidase–glutamate complex 1.67Å AUTH M.B.WEST,Y.CHEN,S.WICKHAM,A.HEROUX,K.CAHILL,M.H.HANIGAN,AUTH 2 B.H.MOOERSTITL NOVEL INSIGHTS INTO EUKARYOTIC GAMMA-GLUTAMYLTRANSPEPTIDASETITL 2 1 FROM THE CRYSTAL STRUCTURE OF THE GLUTAMATE-BOUND HUMANTITL 3 ENZYME.REF J.BIOL.CHEM. V. 288 31902 2013REFN ISSN 0021-9258PMID 24047895DOI 10.1074/JBC.M113.498139 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4gdx GGT1 crystal structure of human gamma-glutamyl transpeptidase–glutamate complex 1.67Å AUTH M.B.WEST,Y.CHEN,S.WICKHAM,A.HEROUX,K.CAHILL,M.H.HANIGAN,AUTH 2 B.H.MOOERSTITL NOVEL INSIGHTS INTO EUKARYOTIC GAMMA-GLUTAMYLTRANSPEPTIDASETITL 2 1 FROM THE CRYSTAL STRUCTURE OF THE GLUTAMATE-BOUND HUMANTITL 3 ENZYME.REF J.BIOL.CHEM. V. 288 31902 2013REFN ISSN 0021-9258PMID 24047895DOI 10.1074/JBC.M113.498139 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1e96 NCF2 structure of the rac/p67phox complex 2.4Å AUTH K.LAPOUGE,S.J.M.SMTIH,P.A.WALKER,S.J.GAMBLIN,AUTH 2 S.J.SMERDON,K.RITTINGERTITL STRUCTURE OF THE TPR DOMAIN OF P67PHOX IN COMPLEXTITL 2 WITH RAC.GTPREF MOL.CELL V. 6 899 2000REFN ISSN 1097-2765PMID 11090627 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1msv AMD1 the s68a s-adenosylmethionine decarboxylase proenzyme processing mutant. 1.75Å AUTH W.D.TOLBERT,Y.ZHANG,S.E.COTTET,E.M.BENNETT,AUTH 2 J.L.EKSTROM,A.E.PEGG,S.E.EALICKTITL MECHANISM OF HUMAN S-ADENOSYLMETHIONINETITL 2 DECARBOXYLASE PROENZYME PROCESSING AS REVEALED BYTITL 3 THE STRUCTURE OF THE S68A MUTANT.REF BIOCHEMISTRY V. 42 2386 2003REFN ISSN 0006-2960PMID 12600205DOI 10.1021/BI0268854 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3fe1 HSPA6 crystal structure of the human 70kda heat shock protein 6 (hsp70b) atpase domain in complex with adp and inorganic phosphate 2.2Å AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,AUTH 2 T.KOTENYOVA,M.MOCHE,H.SCHUELERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOURTITL 2 HUMAN HSP70 ISOFORMS: HSPA1L/HSP70-HOM,TITL 3 HSPA2/HSP70-2, HSPA6/HSP70B, AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN […]