General Structure Information
| PDB ID | 4g84 |
| HGNC Gene Label(s) | HARS |
| Structure Name | crystal structure of human hisrs |
| Resolution | 2.4Å |
| Reference | AUTH Z.XU,Z.WEI,J.J.ZHOU,F.YE,W.S.LO,F.WANG,C.F.LAU,J.WU,AUTH 2 L.A.NANGLE,K.P.CHIANG,X.L.YANG,M.ZHANG,P.SCHIMMELTITL INTERNALLY DELETED HUMAN TRNA SYNTHETASE SUGGESTSTITL 2 EVOLUTIONARY PRESSURE FOR REPURPOSING.REF STRUCTURE V. 20 1470 2012REFN ISSN 0969-2126PMID 22958643DOI 10.1016/J.STR.2012.08.001 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 433 |
| Number Of SNVs | 100 |
| Number Of Permutations | 69398 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.025 |
| p-value | 0.817 |
ClinVar
| Number Of Residues | 433 |
| Number Of SNVs | 3 |
| Number Of Permutations | 412 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.492 |
COSMIC
| Number Of Residues | 433 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2321 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.067 |
| p-value | 0.802 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 100 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.298 |
| p-value | 0.441 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 100 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.042 |
| p-value | 0.922 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
