Assessment of Structural Intolerance and Durability
General Structure Information 2ifv CDC25B crystal structure of an active site mutant, c473d, of cdc25b phosphatase catalytic domain 1.6Å AUTH J.SOHN,G.BUHRMAN,J.RUDOLPHTITL KINETIC AND STRUCTURAL STUDIES OF SPECIFICTITL 2 PROTEIN-PROTEIN INTERACTIONS IN SUBSTRATETITL 3 CATALYSIS BY CDC25B PHOSPHATASE.REF BIOCHEMISTRY V. 46 807 2007REFN ISSN 0006-2960PMID 17223702DOI 10.1021/BI061257Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1pj2 ME2 crystal structure of human mitochondrial nad(p)+-dependent malic enzyme in a pentary complex with natural substrate malate, cofactor nadh, mn++, and allosteric activator fumarate 2.3Å AUTH X.TAO,Z.YANG,L.TONGTITL CRYSTAL STRUCTURES OF SUBSTRATE COMPLEXES OF MALICTITL 2 ENZYME AND INSIGHTS INTO THE CATALYTIC MECHANISM.REF STRUCTURE V. 11 1141 2003REFN ISSN 0969-2126PMID 12962632DOI 10.1016/S0969-2126(03)00168-0 […]
General Structure Information 2v60 MAOB structure of human mao b in complex with the selective inhibitor 7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin 2.0Å AUTH C.BINDA,J.WANG,L.PISANI,C.CACCIA,A.CAROTTI,AUTH 2 P.SALVATI,D.E.EDMONDSON,A.MATTEVITITL STRUCTURES OF HUMAN MONOAMINE OXIDASE B COMPLEXESTITL 2 WITH SELECTIVE NONCOVALENT INHIBITORS: SAFINAMIDETITL 3 AND COUMARIN ANALOGS.REF J.MED.CHEM. V. 50 5848 2007REFN ISSN 0022-2623PMID 17915852DOI 10.1021/JM070677Y Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2nlk PTPRG crystal structure of d1 and d2 catalytic domains of human protein tyrosine phosphatase gamma (d1+d2 ptprg) 2.4Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3qak ADORA2A agonist bound structure of the human adenosine a2a receptor 2.71Å AUTH F.XU,H.WU,V.KATRITCH,G.W.HAN,K.A.JACOBSON,Z.G.GAO,AUTH 2 V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF AN AGONIST-BOUND HUMAN A2A ADENOSINE RECEPTOR.REF SCIENCE V. 332 322 2011REFN ISSN 0036-8075PMID 21393508DOI 10.1126/SCIENCE.1202793 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3szr MX1 crystal structure of modified nucleotide-free human mxa 3.5Å AUTH S.GAO,A.VON DER MALSBURG,A.DICK,K.FAELBER,G.F.SCHRODER,AUTH 2 O.HALLER,G.KOCHS,O.DAUMKETITL STRUCTURE OF MYXOVIRUS RESISTANCE PROTEIN A REVEALS INTRA-TITL 2 AND INTERMOLECULAR DOMAIN INTERACTIONS REQUIRED FOR THETITL 3 ANTIVIRAL FUNCTION.REF IMMUNITY V. 35 514 2011REFN ISSN 1074-7613PMID 21962493DOI 10.1016/J.IMMUNI.2011.07.012 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1ry7 FGFR3 crystal structure of the 3 ig form of fgfr3c in complex with fgf1 3.2Å AUTH S.K.OLSEN,O.A.IBRAHIMI,A.RAUCCI,F.ZHANG,AUTH 2 A.V.ELISEENKOVA,A.YAYON,C.BASILICO,R.J.LINHARDT,AUTH 3 J.SCHLESSINGER,M.MOHAMMADITITL INSIGHTS INTO THE MOLECULAR BASIS FOR FIBROBLASTTITL 2 GROWTH FACTOR RECEPTOR AUTOINHIBITION ANDTITL 3 LIGAND-BINDING PROMISCUITY.REF PROC.NATL.ACAD.SCI.USA V. 101 935 2004REFN ISSN 0027-8424PMID 14732692DOI 10.1073/PNAS.0307287101 Variant Set Distributions Ripley’s K […]
General Structure Information 2qk4 GART human glycinamide ribonucleotide synthetase 2.45Å AUTH M.WELIN,J.G.GROSSMANN,S.FLODIN,T.NYMAN,P.STENMARK,AUTH 2 L.TRESAUGUES,T.KOTENYOVA,I.JOHANSSON,P.NORDLUND,L.LEHTIOTITL STRUCTURAL STUDIES OF TRI-FUNCTIONAL HUMAN GART.REF NUCLEIC ACIDS RES. V. 38 7308 2010REFN ISSN 0305-1048PMID 20631005DOI 10.1093/NAR/GKQ595 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zjd TNFAIP3 a20 otu domain in reduced, active state at 1.87 a resolution 1.87Å AUTH Y.KULATHU,F.J.GARCIA,T.E.T.MEVISSEN,M.BUSCH,N.ARNAUDO,AUTH 2 K.S.CARROLL,D.BARFORD,D.KOMANDERTITL REGULATION OF A20 AND OTHER OTU DEUBIQUITINASES BYTITL 2 REVERSIBLE OXIDATIONREF NAT.COMMUN. V. 4 1569 2013REFN ISSN 2041-1723PMID 23463012DOI 10.1038/NCOMMS2567 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 6pax PAX6 crystal structure of the human pax-6 paired domain-dna complex reveals a general model for pax protein-dna interactions 2.5Å AUTH H.E.XU,M.A.ROULD,W.XU,J.A.EPSTEIN,R.L.MAAS,C.O.PABOTITL CRYSTAL STRUCTURE OF THE HUMAN PAX6 PAIREDTITL 2 DOMAIN-DNA COMPLEX REVEALS SPECIFIC ROLES FOR THETITL 3 LINKER REGION AND CARBOXY-TERMINAL SUBDOMAIN INTITL 4 DNA BINDING.REF GENES DEV. V. 13 1263 […]