General Structure Information
| PDB ID | 1pj2 |
| HGNC Gene Label(s) | ME2 |
| Structure Name | crystal structure of human mitochondrial nad(p)+-dependent malic enzyme in a pentary complex with natural substrate malate, cofactor nadh, mn++, and allosteric activator fumarate |
| Resolution | 2.3Å |
| Reference | AUTH X.TAO,Z.YANG,L.TONGTITL CRYSTAL STRUCTURES OF SUBSTRATE COMPLEXES OF MALICTITL 2 ENZYME AND INSIGHTS INTO THE CATALYTIC MECHANISM.REF STRUCTURE V. 11 1141 2003REFN ISSN 0969-2126PMID 12962632DOI 10.1016/S0969-2126(03)00168-0 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 539 |
| Number Of SNVs | 120 |
| Number Of Permutations | 66783 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.064 |
| p-value | 0.262 |
COSMIC
| Number Of Residues | 539 |
| Number Of SNVs | 3 |
| Number Of Permutations | 201 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.667 |
| p-value | 0.169 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 120 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.554 |
| p-value | 0.177 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
