Assessment of Structural Intolerance and Durability
General Structure Information 1ovz FCAR crystal structure of human fcari 3.0Å AUTH A.B.HERR,E.R.BALLISTER,P.J.BJORKMANTITL INSIGHTS INTO IGA-MEDIATED IMMUNE RESPONSES FROM THE CRYSTALTITL 2 STRUCTURES OF HUMAN FC-ALPHA-RI AND ITS COMPLEX WITH IGA1-FCREF NATURE V. 423 614 2003REFN ISSN 0028-0836PMID 12768205DOI 10.1038/NATURE01685 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1uqs CD1B the crystal structure of human cd1b with a bound bacterial glycolipid 3.1Å AUTH T.BATUWANGALA,D.SHEPHERD,S.D.GADOLA,K.J.C.GIBSON,AUTH 2 N.R.ZACCAI,A.R.FERSHT,G.S.BESRA,V.CERUNDOLO,AUTH 3 E.Y.JONESTITL THE CRYSTAL STRUCTURE OF HUMAN CD1B WITH A BOUNDTITL 2 BACTERIAL GLYCOLIPIDREF J.IMMUNOL. V. 172 2382 2004REFN ISSN 0022-1767PMID 14764708 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2wax DDX6 structure of the human ddx6 c-terminal domain in complex with an edc3-fdf peptide 2.3Å AUTH F.TRITSCHLER,J.E.BRAUN,A.EULALIO,V.TRUFFAULT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL STRUCTURAL BASIS FOR THE MUTUALLY EXCLUSIVETITL 2 ANCHORING OF P BODY COMPONENTS EDC3 AND TRAL TOTITL 3 THE DEAD BOX PROTEIN DDX6/ME31B.REF MOL.CELL V. 33 661 2009REFN ISSN 1097-2765PMID 19285948DOI 10.1016/J.MOLCEL.2009.02.014 Variant […]
General Structure Information 1h9u RXRB the structure of the human retinoid-x-receptor beta ligand binding domain in complex with the specific synthetic agonist lg100268 2.7Å AUTH J.D.LOVE,J.T.GOOCH,S.BENKO,C.LI,L.NAGY,AUTH 2 V.K.K.CHATTERJEE,R.M.EVANS,J.W.R.SCHWABETITL THE STRUCTURAL BASIS FOR THE SPECIFICITY OFTITL 2 RETINOID-X RECEPTOR-SELECTIVE AGONISTS: NEWTITL 3 INSIGHTS INTO THE ROLE OF HELIX H12REF J.BIOL.CHEM. V. 277 11385 2002REFN ISSN 0021-9258PMID […]
General Structure Information 4kfz LMO2 crystal structure of lmo2 and anti-lmo2 vh complex 2.8Å AUTH H.SEWELL,T.TANAKA,K.E.OMARI,E.J.MANCINI,A.CRUZ,AUTH 2 N.FERNANDEZ-FUENTES,J.CHAMBERS,T.H.RABBITTSTITL CONFORMATIONAL FLEXIBILITY OF THE ONCOGENIC PROTEIN LMO2TITL 2 PRIMES THE FORMATION OF THE MULTI-PROTEIN TRANSCRIPTIONTITL 3 COMPLEX.REF SCI REP V. 4 3643 2014REFN ESSN 2045-2322PMID 24407558DOI 10.1038/SREP03643 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4gbx HLA-DMB crystal structure of an immune complex at ph 6.5 3.0Å AUTH W.POS,D.K.SETHI,M.J.CALL,M.S.SCHULZE,A.K.ANDERS,J.PYRDOL,AUTH 2 K.W.WUCHERPFENNIGTITL CRYSTAL STRUCTURE OF THE HLA-DM-HLA-DR1 COMPLEX DEFINESTITL 2 MECHANISMS FOR RAPID PEPTIDE SELECTION.REF CELL(CAMBRIDGE,MASS.) V. 151 1557 2012REFN ISSN 0092-8674PMID 23260142DOI 10.1016/J.CELL.2012.11.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1pvh LIF crystal structure of leukemia inhibitory factor in complex with gp130 2.5Å AUTH M.J.BOULANGER,A.J.BANKOVICH,T.KORTEMME,D.BAKER,AUTH 2 K.C.GARCIATITL CONVERGENT MECHANISMS FOR RECOGNITION OF DIVERGENTTITL 2 CYTOKINES BY THE SHARED SIGNALING RECEPTOR GP130.REF MOL.CELL V. 12 577 2003REFN ISSN 1097-2765PMID 14527405DOI 10.1016/S1097-2765(03)00365-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1n8s PNLIP structure of the pancreatic lipase-colipase complex 3.04Å AUTH H.VAN TILBEURGH,L.SARDA,R.VERGER,C.CAMBILLAUTITL STRUCTURE OF THE PANCREATIC LIPASE-PROCOLIPASETITL 2 COMPLEXREF NATURE V. 359 159 1992REFN ISSN 0028-0836PMID 1522902DOI 10.1038/359159A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2oo0 ODC1 a structural insight into the inhibition of human and leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane 1.9Å AUTH V.T.DUFE,D.INGNER,O.HEBY,A.R.KHOMUTOV,L.PERSSON,AUTH 2 S.AL-KARADAGHITITL A STRUCTURAL INSIGHT INTO THE INHIBITION OF HUMAN ANDTITL 2 LEISHMANIA DONOVANI ORNITHINE DECARBOXYLASES BYTITL 3 1-AMINO-OXY-3-AMINOPROPANE.REF BIOCHEM.J. V. 405 261 2007REFN ISSN 0264-6021PMID 17407445DOI 10.1042/BJ20070188 Variant Set Distributions Ripley’s […]
General Structure Information 1l8k PTPN2 t cell protein-tyrosine phosphatase structure 2.56Å AUTH L.F.IVERSEN,K.B.MOLLER,A.K.PEDERSEN,G.H.PETERS,AUTH 2 A.S.PETERSEN,H.S.ANDERSEN,S.BRANNER,S.B.MORTENSEN,AUTH 3 N.P.MOLLERTITL STRUCTURE DETERMINATION OF T CELL PROTEIN-TYROSINETITL 2 PHOSPHATASE.REF J.BIOL.CHEM. V. 277 19982 2002REFN ISSN 0021-9258PMID 11907034DOI 10.1074/JBC.M200567200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants