1N8S.A | PNLIP

General Structure Information

PDB ID	1n8s
HGNC Gene Label(s)	PNLIP
Structure Name	structure of the pancreatic lipase-colipase complex
Resolution	3.04Å
Reference	AUTH H.VAN TILBEURGH,L.SARDA,R.VERGER,C.CAMBILLAUTITL STRUCTURE OF THE PANCREATIC LIPASE-PROCOLIPASETITL 2 COMPLEXREF NATURE V. 359 159 1992REFN ISSN 0028-0836PMID 1522902DOI 10.1038/359159A0

Variant Set Distributions

ExAC Variants

Number Of Residues	448
Number Of SNVs	122
Number Of Permutations	33920
Optimal Distance Threshold	8.0
K Statistic	0.025
p-value	0.936

COSMIC

Number Of Residues	448
Number Of SNVs	11
Number Of Permutations	13851
Optimal Distance Threshold	4.0
K Statistic	0.018
p-value	0.939

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	122
Number Of COSMIC SNVs	10
Optimal Distance Threshold	4.0
K Statistic	0.021
p-value	0.811

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:118306823	rs568629341	E>K	A:6	(43.76, 18.01, 120.65)
10:118306829		L>F	A:8	(44.21, 21.38, 114.39)
10:118306832	rs371065609	G>S	A:9	(44.63, 24.78, 117.04)
10:118306862	rs201191402	G>R	A:19	(32.10, 39.94, 109.43)
10:118306869	rs140844816	T>M	A:21	(29.85, 41.71, 103.82)
10:118306876	rs149796905	R>S	A:23	(32.99, 34.93, 105.68)
10:118306886		I>V	A:27	(30.01, 31.07, 112.83)
10:118306887		I>T	A:27	(30.01, 31.07, 112.83)
10:118306890	rs144699284	L>W	A:28	(33.60, 29.76, 115.60)
10:118306892	COSM4165389 COSM4165390	P>S	A:29	(35.23, 26.31, 113.82)
10:118306905	COSM3790495 COSM3790494	K>T	A:32	(36.53, 14.91, 118.12)
10:118306915	rs558642726	N>K	A:35	(35.01, 13.13, 111.63)
10:118306919	rs142749694	R>C	A:37	(36.73, 9.01, 107.71)
10:118306931	rs76415321	Y>H	A:41	(40.70, 4.20, 98.09)
10:118306934	rs147154871	T>A	A:42	(46.10, 2.02, 96.51)
10:118306952		N>Y	A:48	(38.05, -1.86, 99.72)
10:118306959		Q>R	A:50	(43.77, 1.39, 103.90)
10:118307878		A>T	A:53	(46.52, 8.61, 110.05)
10:118307881	rs374563946	A>T	A:54	(48.94, 11.37, 111.22)
10:118307885	rs11549160	D>G	A:55	(49.94, 7.91, 113.18)
10:118307887		S>T	A:56	(53.47, 5.88, 112.45)
10:118307924	rs373984432	R>I	A:68	(52.95, 5.52, 95.47)
10:118307929	COSM915152 COSM1584788	T>A	A:70	(49.85, 11.71, 97.68)
10:118307932	rs572893986	R>C	A:71	(47.09, 12.75, 93.45)
10:118307933	COSM342745	R>L	A:71	(47.09, 12.75, 93.45)
10:118307939		I>T	A:73	(39.94, 13.45, 96.68)
10:118307941		I>V	A:74	(38.64, 17.61, 99.62)
10:118307944	rs368162708	H>N	A:75	(33.73, 16.15, 100.44)
10:118307951		F>S	A:77	(26.59, 19.30, 96.93)
10:118307984		N>S	A:88	(35.07, 6.88, 90.61)
10:118310613	COSM1221349 COSM1221350	L>V	A:93	(44.28, 8.02, 89.26)
10:118310626		E>A	A:97	(48.83, 7.11, 88.37)
10:118310631		V>L	A:99	(48.48, 6.83, 93.35)
10:118310634	rs201397700	N>D	A:100	(49.23, 7.44, 97.40)
10:118310638		C>S	A:101	(44.07, 7.94, 96.52)
10:118310646		V>L	A:104	(38.96, 13.66, 102.56)
10:118310658		G>S	A:108	(29.97, 15.98, 109.65)
10:118310659		G>V	A:108	(29.97, 15.98, 109.65)
10:118310662		G>D	A:109	(30.86, 18.97, 108.94)
10:118310668		R>Q	A:111	(26.37, 15.76, 107.69)
10:118310686		A>V	A:117	(30.64, 24.50, 106.73)
10:118310697		I>V	A:121	(36.38, 24.17, 105.58)
10:118310706	COSM3720328 COSM3720327	V>M	A:124	(39.33, 19.80, 106.64)
10:118310721		A>S	A:129	(48.29, 20.09, 106.80)
10:118310728		F>S	A:131	(48.50, 13.08, 106.54)
10:118313240		S>L	A:137	(58.39, 14.63, 109.70)
10:118313243		A>V	A:138	(58.17, 11.11, 109.53)
10:118313249	rs148864963	G>D	A:140	(60.47, 12.98, 104.07)
10:118313254		S>A	A:142	(57.83, 16.54, 99.74)
10:118313257		P>S	A:143	(55.22, 18.57, 100.11)
10:118313266	rs200040515	V>M	A:146	(51.09, 16.62, 97.67)
10:118313271		H>Q	A:147	(46.93, 16.93, 93.71)
10:118313299	rs201757600	A>T	A:157	(39.92, 23.13, 102.18)
10:118313336	rs78536862	I>T	A:169	(51.22, 21.77, 98.37)
10:118313341	rs199957067 COSM4011922 COSM4011921	R>C	A:171	(48.00, 20.15, 91.17)
10:118313350		G>R	A:174	(39.59, 23.34, 91.87)
10:118314699	COSM381307	P>L	A:177	(35.22, 27.02, 93.67)
10:118314704		E>Q	A:179	(29.86, 32.20, 95.09)
10:118314707		P>S	A:180	(28.83, 31.17, 98.84)
10:118314708		P>H	A:180	(28.83, 31.17, 98.84)
10:118314728		E>K	A:187	(43.91, 36.08, 99.38)
10:118314738	rs149884015	R>Q	A:190	(40.29, 33.30, 98.31)
10:118314743		D>H	A:192	(44.99, 31.81, 96.38)
10:118314746	rs373869947	P>T	A:193	(47.18, 31.50, 93.47)
10:118314752		D>N	A:195	(47.22, 28.20, 98.46)
10:118314759	rs564740062	K>R	A:197	(54.46, 25.74, 94.57)
10:118314780	COSM537603 COSM3978126 COSM1139328 COSM3978125	T>M	A:204	(31.35, 24.78, 85.92)
10:118314797		V>I	A:210	(21.60, 35.32, 94.18)
10:118314800		P>S	A:211	(19.57, 35.60, 90.99)
10:118314807		L>W	A:213	(21.08, 28.96, 91.95)
10:118314809		G>W	A:214	(25.71, 30.00, 91.27)
10:118314913		S>R	A:218	(33.20, 33.32, 88.93)
10:118314920		V>M	A:221	(41.09, 31.39, 91.97)
10:118314968		C>R	A:237	(22.97, 20.66, 82.71)
10:118314983		L>F	A:242	(15.51, 32.72, 88.74)
10:118314990		Q>R	A:244	(15.62, 37.61, 93.47)
10:118315002	rs377358755	I>R	A:248	(22.55, 29.01, 100.65)
10:118315007	rs62623373	G>R	A:250	(18.76, 24.39, 101.74)
10:118315016	rs370302522	E>K	A:253	(20.63, 21.34, 104.58)
10:118315019		G>W	A:254	(18.15, 19.56, 101.04)
10:118315518		R>Q	A:256	(14.54, 24.13, 99.80)
10:118315523		F>L	A:258	(20.80, 22.65, 93.28)
10:118315527	rs113176766	A>V	A:259	(20.60, 21.72, 89.99)
10:118315574		V>I	A:275	(41.09, 8.56, 80.72)
10:118315596	rs146995349	G>E	A:282	(42.86, 25.13, 76.25)
10:118315602		P>L	A:284	(43.94, 30.99, 74.93)
10:118315611		S>C	A:287	(35.87, 35.38, 75.94)
10:118315619		V>I	A:290	(35.95, 35.71, 71.42)
10:118318691	COSM683186 COSM1146398	G>E	A:302	(52.93, 26.74, 73.74)
10:118318694		G>D	A:303	(50.30, 25.42, 73.84)
10:118318697		C>F	A:304	(47.07, 24.31, 74.83)
10:118318700		P>Q	A:305	(46.33, 24.19, 78.46)
10:118318708	COSM1221343 COSM1221344	G>S	A:308	(42.96, 19.02, 84.50)
10:118318711	rs371562352	H>N	A:309	(45.22, 14.63, 85.88)
10:118318754		Q>R	A:323	(46.73, 32.06, 83.04)
10:118318760		F>C	A:325	(43.06, 28.92, 79.45)
10:118318771		T>P	A:329	(32.70, 19.69, 76.57)
10:118318780		A>T	A:332	(28.46, 13.06, 78.18)
10:118318795	COSM39500 COSM1560940 COSM1346012 COSM1560939	R>C	A:337	(34.58, 16.85, 72.24)
10:118319968		K>N	A:350	(25.68, 31.45, 42.52)
10:118319969	rs202075908	V>I	A:351	(24.03, 27.57, 44.74)
10:118319978		H>Y	A:354	(23.45, 23.79, 53.96)
10:118320012	rs377432333	N>S	A:365	(35.55, 8.95, 60.61)
10:118320014		S>P	A:366	(34.15, 12.69, 61.35)
10:118320020		Q>K	A:368	(28.67, 15.05, 57.66)
10:118320035	rs372952955	K>Q	A:373	(23.62, 28.23, 56.34)
10:118320988	rs139292695	T>S	A:375	(25.26, 32.25, 48.96)
10:118320995		K>R	A:377	(29.57, 33.22, 45.97)
10:118321015		N>D	A:384	(33.83, 26.58, 61.09)
10:118321016		N>S	A:384	(33.83, 26.58, 61.09)
10:118321026	rs149567242	D>E	A:387	(33.97, 20.78, 68.86)
10:118321030		D>Y	A:389	(33.29, 13.18, 68.75)
10:118321031	rs369523204	D>A	A:389	(33.29, 13.18, 68.75)
10:118321039	rs140196701	V>I	A:392	(41.17, 11.94, 63.15)
10:118321040	rs534482637	V>A	A:392	(41.17, 11.94, 63.15)
10:118321046		D>G	A:394	(47.57, 12.25, 61.09)
10:118321055	rs111319548	M>K	A:397	(40.58, 11.49, 53.16)
10:118321063	COSM683182 COSM1146402	F>I	A:400	(32.10, 19.15, 49.61)
10:118321067		I>T	A:401	(28.39, 17.21, 51.20)
10:118321071		W>C	A:402	(25.40, 20.87, 47.28)
10:118321099	rs187663045	P>S	A:413	(23.15, 22.28, 40.32)
10:118321117		K>E	A:419	(42.01, 24.24, 48.80)
10:118321124		I>T	A:421	(42.76, 24.06, 54.67)
10:118321127		V>A	A:422	(42.44, 20.83, 58.15)
10:118321132		T>A	A:424	(45.22, 20.99, 64.00)
10:118327253	rs370443086	N>K	A:431	(46.38, 21.24, 52.31)
10:118327276		R>K	A:439	(23.70, 17.45, 42.22)
10:118327296		L>F	A:446	(38.97, 16.36, 48.67)
10:118327306		C>Y	A:449	(47.76, 19.45, 47.97)

1N8S.A | PNLIP.

1N8S.A | PNLIP

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:118306827	COSM537606	R>K	A:7	(45.59, 17.73, 116.20)
10:118306869	COSM1474385	T>M	A:21	(29.85, 41.71, 103.82)
10:118306871	COSM3709766	E>K	A:22	(31.49, 38.71, 102.02)
10:118306878	COSM1504423	P>H	A:24	(28.64, 38.10, 108.12)
10:118307955	COSM216914	I>M	A:78	(27.74, 14.91, 98.36)
10:118313243	COSM4637567	A>V	A:138	(58.17, 11.11, 109.53)
10:118313248	COSM427109	G>S	A:140	(60.47, 12.98, 104.07)
10:118313341	COSM4011922	R>C	A:171	(48.00, 20.15, 91.17)
10:118314792	COSM4504782	P>L	A:208	(25.30, 34.33, 89.70)
10:118315008	COSM1703124	G>E	A:250	(18.76, 24.39, 101.74)
10:118315527	COSM3934939	A>V	A:259	(20.60, 21.72, 89.99)
10:118318795	COSM1560940	R>S	A:337	(34.58, 16.85, 72.24)
10:118327281	COSM3434503	E>K	A:441	(22.62, 15.02, 48.72)