General Structure Information
| PDB ID | 1h9u |
| HGNC Gene Label(s) | RXRB |
| Structure Name | the structure of the human retinoid-x-receptor beta ligand binding domain in complex with the specific synthetic agonist lg100268 |
| Resolution | 2.7Å |
| Reference | AUTH J.D.LOVE,J.T.GOOCH,S.BENKO,C.LI,L.NAGY,AUTH 2 V.K.K.CHATTERJEE,R.M.EVANS,J.W.R.SCHWABETITL THE STRUCTURAL BASIS FOR THE SPECIFICITY OFTITL 2 RETINOID-X RECEPTOR-SELECTIVE AGONISTS: NEWTITL 3 INSIGHTS INTO THE ROLE OF HELIX H12REF J.BIOL.CHEM. V. 277 11385 2002REFN ISSN 0021-9258PMID 11782480DOI 10.1074/JBC.M110869200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 201 |
| Number Of SNVs | 23 |
| Number Of Permutations | 3394 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.186 |
| p-value | 0.316 |
COSMIC
| Number Of Residues | 201 |
| Number Of SNVs | 3 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 23 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.199 |
| p-value | 0.625 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
