General Structure Information
| PDB ID | 2ifv |
| HGNC Gene Label(s) | CDC25B |
| Structure Name | crystal structure of an active site mutant, c473d, of cdc25b phosphatase catalytic domain |
| Resolution | 1.6Å |
| Reference | AUTH J.SOHN,G.BUHRMAN,J.RUDOLPHTITL KINETIC AND STRUCTURAL STUDIES OF SPECIFICTITL 2 PROTEIN-PROTEIN INTERACTIONS IN SUBSTRATETITL 3 CATALYSIS BY CDC25B PHOSPHATASE.REF BIOCHEMISTRY V. 46 807 2007REFN ISSN 0006-2960PMID 17223702DOI 10.1021/BI061257Y |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 174 |
| Number Of SNVs | 29 |
| Number Of Permutations | 3535 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.034 |
| p-value | 0.594 |
COSMIC
| Number Of Residues | 174 |
| Number Of SNVs | 3 |
| Number Of Permutations | 77 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.333 |
| p-value | 0.366 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.262 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
