General Structure Information
| PDB ID | 1ry7 |
| HGNC Gene Label(s) | FGFR3 |
| Structure Name | crystal structure of the 3 ig form of fgfr3c in complex with fgf1 |
| Resolution | 3.2Å |
| Reference | AUTH S.K.OLSEN,O.A.IBRAHIMI,A.RAUCCI,F.ZHANG,AUTH 2 A.V.ELISEENKOVA,A.YAYON,C.BASILICO,R.J.LINHARDT,AUTH 3 J.SCHLESSINGER,M.MOHAMMADITITL INSIGHTS INTO THE MOLECULAR BASIS FOR FIBROBLASTTITL 2 GROWTH FACTOR RECEPTOR AUTOINHIBITION ANDTITL 3 LIGAND-BINDING PROMISCUITY.REF PROC.NATL.ACAD.SCI.USA V. 101 935 2004REFN ISSN 0027-8424PMID 14732692DOI 10.1073/PNAS.0307287101 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 213 |
| Number Of SNVs | 49 |
| Number Of Permutations | 43944 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.025 |
| p-value | 0.869 |
ClinVar
| Number Of Residues | 213 |
| Number Of SNVs | 10 |
| Number Of Permutations | 9340 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.444 |
| p-value | 0.005 |
COSMIC
| Number Of Residues | 213 |
| Number Of SNVs | 6 |
| Number Of Permutations | 5578 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.067 |
| p-value | 0.758 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 49 |
| Number Of ClinVar SNVs | 10 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.296 |
| p-value | 0.016 |
Cosmic vs. ExAC
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
