Assessment of Structural Intolerance and Durability
General Structure Information 3w1w FECH protein-drug complex 2.01Å AUTH V.GUPTA,S.LIU,H.ANDO,R.ISHII,S.TATENO,Y.KANEKO,M.YUGAMI,AUTH 2 S.SAKAMOTO,Y.YAMAGUCHI,O.NUREKI,H.HANDATITL SALICYLIC ACID INDUCES MITOCHONDRIAL INJURY BY INHIBITINGTITL 2 FERROCHELATASE HEME BIOSYNTHESIS ACTIVITYREF MOL.PHARMACOL. V. 84 824 2013REFN ISSN 0026-895XPMID 24043703DOI 10.1124/MOL.113.087940 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wfn FLNA filamin a actin binding domain 3.2Å AUTH S.RUSKAMO,J.YLANNETITL STRUCTURE OF THE HUMAN FILAMIN A ACTIN-BINDING DOMAINREF ACTA CRYSTALLOGR.,SECT.D V. 65 1217 2009REFN ISSN 0907-4449PMID 19923718DOI 10.1107/S0907444909037330 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2b3y ACO1 structure of a monoclinic crystal form of human cytosolic aconitase (irp1) 1.85Å AUTH J.DUPUY,A.VOLBEDA,P.CARPENTIER,C.DARNAULT,J.M.MOULIS,AUTH 2 J.C.FONTECILLA-CAMPSTITL CRYSTAL STRUCTURE OF HUMAN IRON REGULATORY PROTEIN 1 ASTITL 2 CYTOSOLIC ACONITASEREF STRUCTURE V. 14 129 2006REFN ISSN 0969-2126PMID 16407072DOI 10.1016/J.STR.2005.09.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2w99 CCND1 crystal structure of cdk4 in complex with a d-type cyclin 2.8Å AUTH P.J.DAY,A.CLEASBY,I.J.TICKLE,M.OREILLY,J.E.COYLE,AUTH 2 F.P.HOLDING,R.L.MCMENAMIN,J.YON,R.CHOPRA,AUTH 3 C.LENGAUER,H.JHOTITITL CRYSTAL STRUCTURE OF HUMAN CDK4 IN COMPLEX WITH ATITL 2 D-TYPE CYCLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 4166 2009REFN ISSN 0027-8424PMID 19237565DOI 10.1073/PNAS.0809645106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1kv3 TGM2 human tissue transglutaminase in gdp bound form 2.8Å AUTH S.LIU,R.A.CERIONE,J.CLARDYTITL STRUCTURAL BASIS FOR THE GUANINETITL 2 NUCLEOTIDE-BINDING ACTIVITY OF TISSUETITL 3 TRANSGLUTAMINASE AND ITS REGULATION OFTITL 4 TRANSAMIDATION ACTIVITY.REF PROC.NATL.ACAD.SCI.USA V. 99 2743 2002REFN ISSN 0027-8424PMID 11867708DOI 10.1073/PNAS.042454899 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2zv6 SERPINB3 crystal structure of human squamous cell carcinoma antigen 1 2.7Å AUTH B.ZHENG,Y.MATOBA,T.KUMAGAI,C.KATAGIRI,T.HIBINO,AUTH 2 M.SUGIYAMATITL CRYSTAL STRUCTURE OF SCCA1 AND INSIGHT ABOUT THETITL 2 INTERACTION WITH JNK1REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 380 143 2009REFN ISSN 0006-291XPMID 19166818DOI 10.1016/J.BBRC.2009.01.057 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3o4o IL1R2 crystal structure of an interleukin-1 receptor complex 3.3Å AUTH D.L.WANG,S.Y.ZHANG,L.LI,X.LIU,K.R.MEI,X.Q.WANGTITL STRUCTURAL INSIGHTS INTO THE ASSEMBLY AND ACTIVATION OFTITL 2 IL-1BETA WITH ITS RECEPTORSREF NAT.IMMUNOL. V. 11 905 2010REFN ISSN 1529-2908PMID 20802483DOI 10.1038/NI.1925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c0y CTSS the crystal structure of a cys25ala mutant of human procathepsin s 2.1Å AUTH G.KAULMANN,G.J.PALM,K.SCHILLING,R.HILGENFELD,AUTH 2 B.WIEDERANDERSTITL THE CRYSTAL STRUCTURE OF A CYS25 -> ALA MUTANT OFTITL 2 HUMAN PROCATHEPSIN S ELUCIDATES ENZYME-PROSEQUENCETITL 3 INTERACTIONS.REF PROTEIN SCI. V. 15 2619 2006REFN ISSN 0961-8368PMID 17075137DOI 10.1110/PS.062401806 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3sn5 CYP7A1 crystal structure of human cyp7a1 in complex with cholest-4-en-3-one 2.75Å AUTH N.STRUSHKEVICH,W.TEMPEL,F.MACKENZIE,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN CYP7A1 IN COMPLEX WITHTITL 2 CHOLEST-4-EN-3-ONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zw3 GJB2 structure of the connexin-26 gap junction channel at 3.5 angstrom resolution 3.5Å AUTH S.MAEDA,S.NAKAGAWA,M.SUGA,E.YAMASHITA,A.OSHIMA,AUTH 2 Y.FUJIYOSHI,T.TSUKIHARATITL STRUCTURE OF THE CONNEXIN 26 GAP JUNCTION CHANNELTITL 2 AT 3.5 A RESOLUTIONREF NATURE V. 458 597 2009REFN ISSN 0028-0836PMID 19340074DOI 10.1038/NATURE07869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]