General Structure Information
| PDB ID | 2wfn |
| HGNC Gene Label(s) | FLNA |
| Structure Name | filamin a actin binding domain |
| Resolution | 3.2Å |
| Reference | AUTH S.RUSKAMO,J.YLANNETITL STRUCTURE OF THE HUMAN FILAMIN A ACTIN-BINDING DOMAINREF ACTA CRYSTALLOGR.,SECT.D V. 65 1217 2009REFN ISSN 0907-4449PMID 19923718DOI 10.1107/S0907444909037330 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 228 |
| Number Of SNVs | 11 |
| Number Of Permutations | 1941 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.255 |
| p-value | 0.161 |
ClinVar
| Number Of Residues | 228 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1389 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.179 |
| p-value | 0.085 |
COSMIC
| Number Of Residues | 228 |
| Number Of SNVs | 5 |
| Number Of Permutations | 485 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.1 |
| p-value | 0.819 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 11 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.107 |
| p-value | 0.077 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 11 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.082 |
| p-value | 0.764 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
