General Structure Information
| PDB ID | 3w1w |
| HGNC Gene Label(s) | FECH |
| Structure Name | protein-drug complex |
| Resolution | 2.01Å |
| Reference | AUTH V.GUPTA,S.LIU,H.ANDO,R.ISHII,S.TATENO,Y.KANEKO,M.YUGAMI,AUTH 2 S.SAKAMOTO,Y.YAMAGUCHI,O.NUREKI,H.HANDATITL SALICYLIC ACID INDUCES MITOCHONDRIAL INJURY BY INHIBITINGTITL 2 FERROCHELATASE HEME BIOSYNTHESIS ACTIVITYREF MOL.PHARMACOL. V. 84 824 2013REFN ISSN 0026-895XPMID 24043703DOI 10.1124/MOL.113.087940 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 359 |
| Number Of SNVs | 77 |
| Number Of Permutations | 37818 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.068 |
| p-value | 0.087 |
ClinVar
| Number Of Residues | 359 |
| Number Of SNVs | 7 |
| Number Of Permutations | 3135 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.143 |
| p-value | 0.056 |
COSMIC
| Number Of Residues | 359 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1887 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.067 |
| p-value | 0.304 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.132 |
| p-value | 0.022 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | -0.416 |
| p-value | 0.061 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
