Assessment of Structural Intolerance and Durability
General Structure Information 3nyo GRK6 crystal structure of g protein-coupled receptor kinase 6 in complex with amp 2.92Å AUTH C.A.BOGUTH,P.SINGH,C.C.HUANG,J.J.TESMERTITL MOLECULAR BASIS FOR ACTIVATION OF G PROTEIN-COUPLED RECEPTORTITL 2 KINASES.REF EMBO J. V. 29 3249 2010REFN ISSN 0261-4189PMID 20729810DOI 10.1038/EMBOJ.2010.206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bwe GPC1 crystal structure of c-terminally truncated glypican-1 after controlled dehydration to 86 percent relative humidity 2.46Å AUTH W.AWAD,G.SVENSSON BIRKEDAL,M.M.G.M.THUNNISSEN,K.MANI,AUTH 2 D.T.LOGANTITL IMPROVEMENTS OF THE ORDER, ISOTROPY AND ELECTRON DENSITY OFTITL 2 GLYPICAN-1 CRYSTALS BY CONTROLLED DEHYDRATIONREF ACTA CRYSTALLOGR.,SECT.D V. 69 2524 2013REFN ISSN 0907-4449PMID 24311593DOI 10.1107/S0907444913025250 Variant Set Distributions Ripley’s K […]
General Structure Information 2bq0 YWHAB 14-3-3 protein beta (human) 2.5Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,AUTH 2 C.V.ROBINSON,J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,AUTH 3 J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONSTITL 2 IN THE 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3whw NUDT1 mth1 in complex with ruthenium-based inhibitor 2.7Å AUTH M.STREIB,K.KRAELING,K.RICHTER,X.XIE,H.STEUBER,E.MEGGERSTITL AN ORGANOMETALLIC INHIBITOR FOR THE HUMAN REPAIR ENZYMETITL 2 7,8-DIHYDRO-8-OXOGUANOSINE TRIPHOSPHATASE.REF ANGEW.CHEM.INT.ED.ENGL. V. 53 305 2014REFN ISSN 1433-7851PMID 24258965DOI 10.1002/ANIE.201307849 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nkr KIR2DL1 inhibitory receptor (p58-cl42) for human natural killer cells 1.7Å AUTH Q.R.FAN,L.MOSYAK,C.C.WINTER,N.WAGTMANN,E.O.LONG,AUTH 2 D.C.WILEYTITL STRUCTURE OF THE INHIBITORY RECEPTOR FOR HUMANTITL 2 NATURAL KILLER CELLS RESEMBLES HAEMATOPOIETICTITL 3 RECEPTORS.REF NATURE V. 389 96 1997REFN ISSN 0028-0836PMID 9288975DOI 10.1038/38028 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4djh OPRK1 structure of the human kappa opioid receptor in complex with jdtic 2.9Å AUTH H.WU,D.WACKER,M.MILENI,V.KATRITCH,G.W.HAN,E.VARDY,W.LIU,AUTH 2 A.A.THOMPSON,X.P.HUANG,F.I.CARROLL,S.W.MASCARELLA,AUTH 3 R.B.WESTKAEMPER,P.D.MOSIER,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL TRUCTURE OF THE HUMAN KAPPA-OPIOID RECEPTOR IN COMPLEX WITHTITL 2 JDTICREF NATURE V. 485 327 2012REFN ISSN 0028-0836PMID 22437504DOI 10.1038/NATURE10939 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1yo8 THBS2 structure of the c-terminal domain of human thrombospondin-2 2.6Å AUTH C.B.CARLSON,D.A.BERNSTEIN,D.S.ANNIS,T.M.MISENHEIMER,AUTH 2 B.L.HANNAH,D.F.MOSHER,J.L.KECKTITL STRUCTURE OF THE CALCIUM-RICH SIGNATURE DOMAIN OF HUMANTITL 2 THROMBOSPONDIN-2REF NAT.STRUCT.MOL.BIOL. V. 12 910 2005REFN ISSN 1545-9993PMID 16186819DOI 10.1038/NSMB997 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1jm7 BRCA1 solution structure of the brca1/bard1 ring-domain heterodimer -1.0Å AUTH P.S.BRZOVIC,P.RAJAGOPAL,D.W.HOYT,M.C.KING,AUTH 2 R.E.KLEVITTITL STRUCTURE OF A BRCA1-BARD1 HETERODIMERIC RING-RINGTITL 2 COMPLEX.REF NAT.STRUCT.BIOL. V. 8 833 2001REFN ISSN 1072-8368PMID 11573085DOI 10.1038/NSB1001-833 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lce BCL6 chemical shift assignment of hr4436b from homo sapiens, northeast structural genomics consortium -1.0Å AUTH H.LEE,G.T.MONTELIONE,J.H.PRESTEGARDTITL SOLUTION STRUCTURE OF HR4436B.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fb1 GCH1 crystal structure of human gtp cyclohydrolase i 3.1Å AUTH G.AUERBACH,A.HERRMANN,A.BRACHER,G.BADER,M.GUTLICH,M.FISCHER,AUTH 2 M.NEUKAMM,M.GARRIDO-FRANCO,J.RICHARDSON,H.NAR,R.HUBER,AUTH 3 A.BACHERTITL ZINC PLAYS A KEY ROLE IN HUMAN AND BACTERIAL GTPTITL 2 CYCLOHYDROLASE I.REF PROC.NATL.ACAD.SCI.USA V. 97 13567 2000REFN ISSN 0027-8424PMID 11087827DOI 10.1073/PNAS.240463497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]