Assessment of Structural Intolerance and Durability
General Structure Information 4gqs CYP2C19 structure of human microsomal cytochrome p450 (cyp) 2c19 2.87Å AUTH R.L.REYNALD,S.SANSEN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURAL CHARACTERIZATION OF HUMAN CYTOCHROME P450 2C19:TITL 2 ACTIVE SITE DIFFERENCES BETWEEN P450S 2C8, 2C9, AND 2C19.REF J.BIOL.CHEM. V. 287 44581 2012REFN ISSN 0021-9258PMID 23118231DOI 10.1074/JBC.M112.424895 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1nwt CHI3L1 crystal structure of human cartilage gp39 (hc-gp39) in complex with chitopentaose 2.5Å AUTH F.FUSETTI,T.PIJNING,K.H.KALK,E.BOS,B.W.DIJKSTRATITL CRYSTAL STRUCTURE AND CARBOHYDRATE-BINDING PROPERTIES OF THETITL 2 HUMAN CARTILAGE GLYCOPROTEIN-39REF J.BIOL.CHEM. V. 278 37753 2003REFN ISSN 0021-9258PMID 12851408DOI 10.1074/JBC.M303137200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1gh7 CSF2RB crystal structure of the complete extracellular domain of the beta- common receptor of il-3, il-5, and gm-csf 3.0Å AUTH P.D.CARR,S.E.GUSTIN,A.P.CHURCH,J.M.MURPHY,S.C.FORD,D.A.MANN,AUTH 2 D.M.WOLTRING,I.WALKER,D.L.OLLIS,I.G.YOUNGTITL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE COMMONTITL 2 BETA SUBUNIT OF THE HUMAN GM-CSF, IL-3, AND IL-5 RECEPTORSTITL 3 REVEALS A NOVEL DIMER CONFIGURATION.REF CELL(CAMBRIDGE,MASS.) V. […]
General Structure Information 2c5d AXL structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zns GRIK1 crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, glur5, in complex with glutamate 2.0Å AUTH M.UNNO,M.SHINOHARA,K.TAKAYAMA,H.TANAKA,K.TERUYA,K.DOH-URA,AUTH 2 R.SAKAI,M.SASAKI,M.IKEDA-SAITOTITL BINDING AND SELECTIVITY OF THE MARINE TOXIN NEODYSIHERBAINETITL 2 A AND ITS SYNTHETIC ANALOGUES TO GLUK1 AND GLUK2 KAINATETITL 3 RECEPTORS.REF J.MOL.BIOL. V. 413 667 2011REFN ISSN 0022-2836PMID […]
General Structure Information 3kvq KDR crystal structure of vegfr2 extracellular domain d7 2.7Å AUTH Y.YANG,P.XIE,Y.OPATOWSKY,J.SCHLESSINGERTITL DIRECT CONTACTS BETWEEN EXTRACELLULARTITL 2 MEMBRANE-PROXIMAL DOMAINS ARE REQUIRED FOR VEGFTITL 3 RECEPTOR ACTIVATION AND CELL SIGNALINGREF PROC.NATL.ACAD.SCI.USA V. 107 1906 2010REFN ISSN 0027-8424PMID 20080685DOI 10.1073/PNAS.0914052107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4dg4 PRSS3 human mesotrypsin-s39y complexed with bovine pancreatic trypsin inhibitor (bpti) 1.4Å AUTH M.A.SALAMEH,A.S.SOARES,A.ALLOY,E.S.RADISKYTITL PRESENCE VERSUS ABSENCE OF HYDROGEN BOND DONOR TYR-39TITL 2 INFLUENCES INTERACTIONS OF CATIONIC TRYPSIN AND MESOTRYPSINTITL 3 WITH PROTEIN PROTEASE INHIBITORS.REF PROTEIN SCI. V. 21 1103 2012REFN ISSN 0961-8368PMID 22610453DOI 10.1002/PRO.2097 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2xyn ABL2 human abl2 in complex with aurora kinase inhibitor vx-680 2.81Å AUTH E.SALAH,E.UGOCHUKWU,A.J.BARR,F.VON DELFT,S.KNAPP,AUTH 2 J.M.ELKINSTITL CRYSTAL STRUCTURES OF ABL-RELATED GENE (ABL2) INTITL 2 COMPLEX WITH IMATINIB, TOZASERTIB (VX-680), AND ATITL 3 TYPE I INHIBITOR OF THE TRIAZOLE CARBOTHIOAMIDETITL 4 CLASS.REF J.MED.CHEM. V. 54 2359 2011REFN ISSN 0022-2623PMID 21417343DOI 10.1021/JM101506N Variant […]
General Structure Information 3dzy PPARG intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide 3.1Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 2i3c ASPA crystal structure of an aspartoacylase from homo sapiens 2.8Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,J.G.MCCOY,AUTH 2 G.N.PHILLIPSTITL STRUCTURE OF ASPARTOACYLASE, THE BRAIN ENZYMETITL 2 IMPAIRED IN CANAVAN DISEASE.REF PROC.NATL.ACAD.SCI.USA V. 104 456 2007REFN ISSN 0027-8424PMID 17194761DOI 10.1073/PNAS.0607817104 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants