General Structure Information
| PDB ID | 3kvq |
| HGNC Gene Label(s) | KDR |
| Structure Name | crystal structure of vegfr2 extracellular domain d7 |
| Resolution | 2.7Å |
| Reference | AUTH Y.YANG,P.XIE,Y.OPATOWSKY,J.SCHLESSINGERTITL DIRECT CONTACTS BETWEEN EXTRACELLULARTITL 2 MEMBRANE-PROXIMAL DOMAINS ARE REQUIRED FOR VEGFTITL 3 RECEPTOR ACTIVATION AND CELL SIGNALINGREF PROC.NATL.ACAD.SCI.USA V. 107 1906 2010REFN ISSN 0027-8424PMID 20080685DOI 10.1073/PNAS.0914052107 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 82 |
| Number Of SNVs | 20 |
| Number Of Permutations | 1187 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.079 |
| p-value | 0.969 |
COSMIC
| Number Of Residues | 82 |
| Number Of SNVs | 4 |
| Number Of Permutations | 16 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 20 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | -0.142 |
| p-value | 0.871 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
