Assessment of Structural Intolerance and Durability
General Structure Information 4iqr HNF4A multi-domain organization of the hnf4alpha nuclear receptor complex on dna 2.9Å AUTH V.CHANDRA,P.HUANG,N.POTLURI,D.WU,Y.KIM,F.RASTINEJADTITL MULTIDOMAIN INTEGRATION IN THE STRUCTURE OF THE HNF-4 ALPHATITL 2 NUCLEAR RECEPTOR COMPLEX.REF NATURE V. 495 394 2013REFN ISSN 0028-0836PMID 23485969DOI 10.1038/NATURE11966 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mkj KIF5B human kinesin motor domain with docked neck linker 2.7Å AUTH C.V.SINDELAR,M.J.BUDNY,S.RICE,N.NABER,R.FLETTERICK,AUTH 2 R.COOKETITL TWO CONFORMATIONS IN THE HUMAN KINESIN POWERTITL 2 STROKE DEFINED BY X-RAY CRYSTALLOGRAPHY AND EPRTITL 3 SPECTROSCOPY.REF NAT.STRUCT.BIOL. V. 9 844 2002REFN ISSN 1072-8368PMID 12368902 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1rjb FLT3 crystal structure of flt3 2.1Å AUTH J.GRIFFITH,J.BLACK,C.FAERMAN,L.SWENSON,M.WYNN,F.LU,AUTH 2 J.LIPPKE,K.SAXENATITL THE STRUCTURAL BASIS FOR AUTOINHIBITION OF FLT3 BYTITL 2 THE JUXTAMEMBRANE DOMAIN.REF MOL.CELL V. 13 169 2004REFN ISSN 1097-2765PMID 14759363DOI 10.1016/S1097-2765(03)00505-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1d1j PFN2 crystal structure of human profilin ii 2.2Å AUTH I.M.NODELMAN,G.D.BOWMAN,U.LINDBERG,C.E.SCHUTTTITL X-RAY STRUCTURE DETERMINATION OF HUMAN PROFILINTITL 2 II: A COMPARATIVE STRUCTURAL ANALYSIS OF HUMANTITL 3 PROFILINS.REF J.MOL.BIOL. V. 294 1271 1999REFN ISSN 0022-2836PMID 10600384DOI 10.1006/JMBI.1999.3318 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1imv SERPINF1 2.85 a crystal structure of pedf 2.85Å AUTH M.SIMONOVIC,P.G.GETTINS,K.VOLZTITL CRYSTAL STRUCTURE OF HUMAN PEDF, A POTENT ANTI-ANGIOGENICTITL 2 AND NEURITE GROWTH-PROMOTING FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 98 11131 2001REFN ISSN 0027-8424PMID 11562499DOI 10.1073/PNAS.211268598 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n3k USP8 the catalytic domain of usp8 in complex with a usp8 specific inhibitor 2.6Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K […]
General Structure Information 2edb DCC solution structure of the fourth fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wwy RECQL structure of human recq-like helicase in complex with a dna substrate 2.9Å AUTH A.C.W.PIKE,Y.ZHANG,C.SCHNECKE,A.CHAIKUAD,T.KROJER,AUTH 2 C.D.O.COOPER,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,C.BOUNTRA,O.GILEADITITL RECQ1 HELICASE-DRIVEN DNA UNWINDING, ANNEALING, AND BRANCHTITL 2 MIGRATION: INSIGHTS FROM DNA COMPLEX STRUCTURESREF PROC.NATL.ACAD.SCI.USA V. 112 4286 2015REFN ISSN 0027-8424PMID 25831490DOI 10.1073/PNAS.1417594112 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3rze HRH1 structure of the human histamine h1 receptor in complex with doxepin 3.1Å AUTH T.SHIMAMURA,M.SHIROISHI,S.WEYAND,H.TSUJIMOTO,G.WINTER,AUTH 2 V.KATRITCH,R.ABAGYAN,V.CHEREZOV,W.LIU,G.W.HAN,T.KOBAYASHI,AUTH 3 R.C.STEVENS,S.IWATATITL STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR COMPLEX WITHTITL 2 DOXEPIN.REF NATURE V. 475 65 2011REFN ISSN 0028-0836PMID 21697825DOI 10.1038/NATURE10236 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3l5h IL6ST crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes 3.6Å AUTH Y.XU,N.KERSHAW,C.S.LUO,P.SOO,M.POCOCK,P.E.CZABOTAR,AUTH 2 D.J.HILTON,N.A.NICOLA,T.P.J.GARRETT,J.G.ZHANGTITL CRYSTAL STRUCTURE OF THE ENTIRE ECTODOMAIN OF GP130:TITL 2 INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINETITL 3 RECEPTOR COMPLEXESREF TO BE PUBLISHEDREFN Variant Set Distributions […]