General Structure Information
| PDB ID | 1d1j |
| HGNC Gene Label(s) | PFN2 |
| Structure Name | crystal structure of human profilin ii |
| Resolution | 2.2Å |
| Reference | AUTH I.M.NODELMAN,G.D.BOWMAN,U.LINDBERG,C.E.SCHUTTTITL X-RAY STRUCTURE DETERMINATION OF HUMAN PROFILINTITL 2 II: A COMPARATIVE STRUCTURAL ANALYSIS OF HUMANTITL 3 PROFILINS.REF J.MOL.BIOL. V. 294 1271 1999REFN ISSN 0022-2836PMID 10600384DOI 10.1006/JMBI.1999.3318 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 137 |
| Number Of SNVs | 20 |
| Number Of Permutations | 5530 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.379 |
| p-value | 0.089 |
COSMIC
| Number Of Residues | 137 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 20 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.267 |
| p-value | 0.485 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
