Assessment of Structural Intolerance and Durability
General Structure Information 1bi8 CDK6 mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2wno TNFAIP6 x-ray structure of cub_c domain from tsg-6 2.3Å AUTH D.C.BRIGGS,H.L.BIRCHENOUGH,T.ALI,M.S.RUGG,J.P.WALTHO,AUTH 2 E.IEVOLI,T.A.JOWITT,J.J.ENGHILD,R.P.RICHTER,A.SALUSTRI,AUTH 3 C.M.MILNER,A.J.DAYTITL METAL ION-DEPENDENT HEAVY CHAIN TRANSFER ACTIVITY OF TSG-6TITL 2 MEDIATES ASSEMBLY OF THE CUMULUS-OOCYTE MATRIXREF J.BIOL.CHEM. 2015REFN ESSN 1083-351XPMID 26468290DOI 10.1074/JBC.M115.669838 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i6a ADK human adenosine kinase in complex with 5-deoxy-5- iodotubercidin 2.2Å AUTH S.W.MUCHMORE,R.A.SMITH,A.O.STEWART,M.D.COWART,AUTH 2 A.GOMTSYAN,M.A.MATULENKO,H.YU,J.M.SEVERIN,AUTH 3 S.S.BHAGWAT,C.H.LEE,E.A.KOWALUK,M.F.JARVIS,AUTH 4 C.L.JAKOBTITL CRYSTAL STRUCTURES OF HUMAN ADENOSINE KINASETITL 2 INHIBITOR COMPLEXES REVEAL TWO DISTINCT BINDINGTITL 3 MODES.REF J.MED.CHEM. V. 49 6726 2006REFN ISSN 0022-2623PMID 17154503DOI 10.1021/JM060189A Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1d5r PTEN crystal structure of the pten tumor suppressor 2.1Å AUTH J.O.LEE,H.YANG,M.M.GEORGESCU,A.DI CRISTOFANO,AUTH 2 T.MAEHAMA,Y.SHI,J.E.DIXON,P.PANDOLFI,N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF THE PTEN TUMOR SUPPRESSOR:TITL 2 IMPLICATIONS FOR ITS PHOSPHOINOSITIDE PHOSPHATASETITL 3 ACTIVITY AND MEMBRANE ASSOCIATION.REF CELL(CAMBRIDGE,MASS.) V. 99 323 1999REFN ISSN 0092-8674PMID 10555148DOI 10.1016/S0092-8674(00)81663-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3e1y ETF1 crystal structure of human erf1/erf3 complex 3.8Å AUTH Z.CHENG,K.SAITO,A.V.PISAREV,M.WADA,V.P.PISAREVA,T.V.PESTOVA,AUTH 2 M.GAJDA,A.ROUND,C.KONG,M.LIM,Y.NAKAMURA,D.I.SVERGUN,K.ITO,AUTH 3 H.SONGTITL STRUCTURAL INSIGHTS INTO ERF3 AND STOP CODON RECOGNITION BYTITL 2 ERF1REF GENES DEV. V. 23 1106 2009REFN ISSN 0890-9369PMID 19417105DOI 10.1101/GAD.1770109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yg5 HBA2 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]
General Structure Information 1yg5 HBA1 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]
General Structure Information 4bw5 KCNK10 crystal structure of human two pore domain potassium ion channel trek2 (k2p10.1) 3.4Å AUTH A.C.W.PIKE,A.MACKENZIE,C.MCCLENAGHAN,P.ARYAL,L.DONG,AUTH 2 A.QUIGLEY,M.GRIEBEN,S.GOUBIN,S.MUKHOPADHYAY,G.F.RUDA,AUTH 3 M.V.CLAUSEN,L.CAO,P.E.BRENNAN,N.A.BURGESS-BROWN,AUTH 4 M.S.P.SANSOM,S.J.TUCKER,E.P.CARPENTERTITL K2P CHANNEL GATING MECHANISMS REVEALED BY STRUCTURES OFTITL 2 TREK-2 AND A COMPLEX WITH PROZACREF SCIENCE V. 347 1256 2015REFN ISSN 0036-8075PMID 25766236DOI 10.1126/SCIENCE.1261512 Variant Set Distributions Ripley’s K […]
General Structure Information 3v3k CASP9 human caspase 9 in complex with bacterial effector protein 3.49Å AUTH M.MOERTL,K.MASKOS,H.STEUBERTITL HUMAN CASPASE 9 IN COMPLEX WITH BACTERIAL EFFECTOR PROTEINREF PLOS ONE 2013REFN ESSN 1932-6203 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1hur ARF1 human adp-ribosylation factor 1 complexed with gdp, full length non-myristoylated 2.0Å AUTH J.C.AMOR,D.H.HARRISON,R.A.KAHN,D.RINGETITL STRUCTURE OF THE HUMAN ADP-RIBOSYLATION FACTOR 1TITL 2 COMPLEXED WITH GDP.REF NATURE V. 372 704 1994REFN ISSN 0028-0836PMID 7990966DOI 10.1038/372704A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants