Assessment of Structural Intolerance and Durability
General Structure Information 1yb1 HSD17B11 crystal structure of human 17-beta-hydroxysteroid dehydrogenase type xi 1.95Å AUTH P.LUKACIK,G.BUNKOCZI,K.KAVANAGH,S.NG,F.VON DELFT,J.BRAY,AUTH 2 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE XI.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2pla GPD1L crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein 2.51Å AUTH J.UPPENBERG,C.SMEE,V.HOZJAN,K.KAVANAGH,G.BUNKOCZI,AUTH 2 E.PAPAGRIGORIOU,A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,AUTH 3 J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLYCEROL-3-PHOSPHATETITL 2 DEHYDROGENASE 1-LIKE PROTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l73 NOXO1 structure of the noxo1b px domain -1.0Å AUTH N.Y.DAVIS,L.C.MCPHAIL,D.A.HORITATITL STRUCTURE OF THE NOXO1B PX DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3uyj KDM8 crystal structure of jmjd5 catalytic core domain in complex with nickle and alpha-kg 2.35Å AUTH X.SU,H.LITITL CRYSTAL STRUCTURE OF JMJD5 CATALYTIC CORE DOMAIN IN COMPLEXTITL 2 WITH NICKLE AND ALPHA-KGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hf1 RRM2B crystal structure of human p53r2 2.6Å AUTH P.SMITH,B.ZHOU,N.HO,Y.C.YUAN,L.SU,S.C.TSAI,Y.YENTITL 2.6 A X-RAY CRYSTAL STRUCTURE OF HUMAN P53R2, ATITL 2 P53-INDUCIBLE RIBONUCLEOTIDE REDUCTASE .REF BIOCHEMISTRY V. 48 11134 2009REFN ISSN 0006-2960PMID 19728742DOI 10.1021/BI9001425 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4c8d KDM3B crystal structure of jmjc domain of human histone 3 lysine- specific demethylase 3b (kdm3b) 2.18Å AUTH M.VOLLMAR,C.JOHANSSON,C.GILEADI,S.GOUBIN,A.SZYKOWSKA,AUTH 2 T.KROJER,L.CRAWLEY,F.VON DELFT,C.H.ARROWSMITH,C.BOUNTRA,AUTH 3 A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE 3TITL 2 LYSINE-SPECIFIC DEMETHYLASE 3B (KDM3B)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1w6u DECR1 structure of human decr ternary complex 1.75Å AUTH M.S.ALPHEY,W.YU,E.BYRES,D.LI,W.N.HUNTERTITL STRUCTURE AND REACTIVITY OF HUMAN MITOCHONDRIALTITL 2 2,4-DIENOYL-COA REDUCTASE: ENZYME-LIGANDTITL 3 INTERACTIONS IN A DISTINCTIVE SHORT-CHAINTITL 4 REDUCTASE ACTIVE SITEREF J.BIOL.CHEM. V. 280 3068 2005REFN ISSN 0021-9258PMID 15531764DOI 10.1074/JBC.M411069200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3t3s CYP2A13 human cytochrome p450 2a13 in complex with pilocarpine 3.0Å AUTH N.M.DEVORE,K.M.MENEELY,A.G.BART,E.S.STEPHENS,K.P.BATTAILE,AUTH 2 E.E.SCOTTTITL STRUCTURAL COMPARISON OF CYTOCHROMES P450 2A6, 2A13, AND 2E1TITL 2 WITH PILOCARPINE.REF FEBS J. V. 279 1621 2012REFN ISSN 1742-464XPMID 22051186DOI 10.1111/J.1742-4658.2011.08412.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2oby TP53I3 crystal structure of human p53 inducible oxidoreductase (tp53i3,pig3) 3.0Å AUTH S.PORTE,E.VALENCIA,J.FARRES,I.FITA,A.C.W.PIKE,N.SHAFQAT,AUTH 2 J.DEBRECZENI,C.JOHANSSON,A.HARONITI,O.GILEADI,AUTH 3 C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,M.SUNDSTROM,F.VON DELFT,AUTH 4 U.OPPERMANN,X.PARESTITL CRYSTAL STRUCTURE OF HUMAN P53 INDUCIBLE OXIDOREDUCTASETITL 2 (TP53I3, PIG3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qj4 RNLS crystal structure of human renalase (isoform 1) 2.5Å AUTH M.MILANI,F.CIRIELLO,S.BARONI,V.PANDINI,G.CANEVARI,AUTH 2 M.BOLOGNESI,A.ALIVERTITITL FAD-BINDING SITE AND NADP REACTIVITY IN HUMAN RENALASE: ATITL 2 NEW ENZYME INVOLVED IN BLOOD PRESSURE REGULATIONREF J.MOL.BIOL. V. 411 463 2011REFN ISSN 0022-2836PMID 21699903DOI 10.1016/J.JMB.2011.06.010 Variant Set Distributions Mapped Variants