3QJ4.A | RNLS – ASTRID

3QJ4.A | RNLS

General Structure Information

PDB ID	3qj4
HGNC Gene Label(s)	RNLS
Structure Name	crystal structure of human renalase (isoform 1)
Resolution	2.5Å
Reference	AUTH M.MILANI,F.CIRIELLO,S.BARONI,V.PANDINI,G.CANEVARI,AUTH 2 M.BOLOGNESI,A.ALIVERTITITL FAD-BINDING SITE AND NADP REACTIVITY IN HUMAN RENALASE: ATITL 2 NEW ENZYME INVOLVED IN BLOOD PRESSURE REGULATIONREF J.MOL.BIOL. V. 411 463 2011REFN ISSN 0022-2836PMID 21699903DOI 10.1016/J.JMB.2011.06.010

Variant Set Distributions

ExAC Variants

Number Of Residues	335
Number Of SNVs	88
Number Of Permutations	40640
Optimal Distance Threshold	11.0
K Statistic	0.075
p-value	0.653

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:90342920		G>R	A:10	(12.63, -5.53, 26.17)
10:90342911		G>R	A:13	(10.37, -2.08, 28.73)
10:90342907		S>N	A:14	(13.31, -2.78, 30.43)
10:90342901		C>S	A:16	(9.99, 1.86, 30.89)
10:90342895	rs376585268	A>E	A:18	(13.65, 1.44, 35.29)
10:90342880		Q>P	A:23	(10.96, 10.59, 39.10)
10:90342853		V>G	A:32	(6.83, -7.49, 33.04)
10:90342848		D>H	A:34	(7.16, -11.76, 27.19)
10:90342837	rs2296545	E>D	A:37	(10.44, -18.95, 26.91)
10:90342050	rs572861626	T>A	A:45	(21.39, -14.39, 23.84)
10:90342047	rs557592363	A>S	A:46	(21.59, -18.00, 22.44)
10:90342044		C>R	A:47	(22.41, -21.06, 24.89)
10:90342028		P>L	A:52	(25.73, -22.49, 29.40)
10:90342029		P>S	A:52	(25.73, -22.49, 29.40)
10:90342025	rs377332197	Q>R	A:53	(29.41, -20.09, 29.53)
10:90342026	COSM3791010 COSM3791009	Q>E	A:53	(29.41, -20.09, 29.53)
10:90342023		C>G	A:54	(28.26, -21.09, 24.21)
10:90342017		A>P	A:56	(24.65, -16.13, 20.55)
10:90342011		L>V	A:58	(20.17, -14.56, 17.32)
10:90341989		C>Y	A:65	(27.43, 6.05, 19.76)
10:90341986		T>S	A:66	(25.89, 8.91, 17.43)
10:90341983	rs369122040	P>L	A:67	(28.24, 12.12, 17.94)
10:90341974		A>V	A:70	(26.53, 11.61, 22.98)
10:90341968	rs199960560	K>I	A:72	(20.42, 13.49, 24.23)
10:90341959		R>H	A:75	(20.89, 9.29, 32.42)
10:90341960	rs147588689	R>C	A:75	(20.89, 9.29, 32.42)
10:90341452		L>P	A:80	(25.35, 0.28, 30.76)
10:90341443		Y>C	A:83	(26.54, -1.41, 36.88)
10:90341434		L>S	A:86	(28.34, -1.99, 27.58)
10:90341432		R>G	A:87	(33.82, -4.71, 27.16)
10:90341417	rs375317118	P>S	A:92	(38.17, -6.68, 13.73)
10:90341407		G>V	A:95	(32.23, -2.90, 6.21)
10:90341385	rs149825485	D>E	A:102	(30.64, 7.03, 15.35)
10:90341386		D>G	A:102	(30.64, 7.03, 15.35)
10:90341383		C>S	A:103	(31.60, 4.70, 19.52)
10:90341359	rs140158928	I>T	A:111	(23.23, -7.83, 23.75)
10:90341351	rs367718389	I>V	A:114	(21.39, -4.49, 28.45)
10:90332795		R>C	A:131	(-0.69, -14.56, 23.50)
10:90332784	rs139294588	Q>H	A:134	(-8.79, -9.45, 24.70)
10:90332786		Q>K	A:134	(-8.79, -9.45, 24.70)
10:90332782		I>N	A:135	(-6.75, -4.79, 26.32)
10:90332774		R>G	A:138	(-14.60, -4.54, 31.79)
10:90332762		W>G	A:142	(-7.25, -0.71, 31.11)
10:90332749		K>R	A:146	(-3.66, -14.51, 29.91)
10:90332743		T>R	A:148	(-3.36, -19.67, 29.77)
10:90332721		D>E	A:155	(-4.36, 1.14, 37.36)
10:90332723	COSM3807913 COSM3807912	D>N	A:155	(-4.36, 1.14, 37.36)
10:90332714		V>L	A:158	(3.09, 0.32, 28.56)
10:90332708		T>P	A:160	(6.64, -2.41, 23.96)
10:90332703	rs41317260	M>I	A:161	(4.04, -5.08, 21.19)
10:90332669		I>V	A:173	(-7.58, -1.78, 22.12)
10:90122468	rs78525460	Q>K	A:181	(-4.69, 6.99, 16.38)
10:90122447		V>L	A:188	(4.29, 1.15, 10.72)
10:90122431	rs556716831 COSM76272 COSM1349652 COSM1349651	R>Q	A:193	(16.71, -9.44, 8.12)
10:90122429		Y>H	A:194	(14.96, -16.45, 8.52)
10:90122398	COSM4016456 COSM4016455	T>M	A:204	(39.93, -21.85, 14.53)
10:90122388	rs116376263	D>E	A:207	(40.62, -18.26, 11.82)
10:90122384		P>S	A:209	(41.21, -11.85, 10.26)
10:90122378		A>T	A:211	(34.85, -10.71, 14.00)
10:90122360	rs151245420	S>G	A:217	(27.88, -9.91, -2.96)
10:90122354		P>S	A:219	(22.19, -13.95, -2.53)
10:90122344	rs191733133	R>H	A:222	(24.10, -7.60, 4.59)
10:90122345		R>C	A:222	(24.10, -7.60, 4.59)
10:90122339		V>I	A:224	(29.21, -13.18, 9.28)
10:90122335		S>F	A:225	(29.67, -12.95, 13.66)
10:90122332	rs188639368	I>T	A:226	(33.24, -14.60, 15.09)
10:90122333	rs143744963	I>V	A:226	(33.24, -14.60, 15.09)
10:90122318		R>C	A:231	(31.40, -11.73, 23.47)
10:90122314	rs117446494	N>S	A:232	(37.57, -10.26, 23.70)
10:90074395		S>L	A:235	(38.44, -18.74, 27.50)
10:90074396	rs148749882	S>P	A:235	(38.44, -18.74, 27.50)
10:90074381	rs149300466	P>S	A:240	(33.61, -21.39, 18.64)
10:90074374		L>P	A:242	(28.96, -18.49, 13.50)
10:90074375		L>I	A:242	(28.96, -18.49, 13.50)
10:90074359		T>S	A:247	(18.82, -10.61, 2.95)
10:90074357		V>I	A:248	(15.25, -8.41, 3.38)
10:90074353		P>L	A:249	(15.12, -10.31, -0.00)
10:90074354		P>A	A:249	(15.12, -10.31, -0.00)
10:90074338	rs200181983	Y>C	A:254	(12.63, -18.66, 1.83)
10:90074331		E>D	A:256	(4.92, -18.35, 5.10)
10:90074330		H>N	A:257	(9.27, -21.59, 3.29)
10:90074323		I>T	A:259	(12.72, -23.60, 10.41)
10:90074321		E>K	A:260	(14.75, -28.34, 9.29)
10:90074303		V>L	A:266	(21.98, -20.40, 5.28)
10:90074282	rs376888167	I>V	A:273	(31.04, -16.64, 2.33)
10:90074275		P>L	A:275	(35.56, -22.20, 2.76)
10:90074261		P>A	A:280	(28.01, -27.66, 13.52)
10:90074237		W>R	A:288	(14.28, -11.89, 14.38)
10:90074229		H>Q	A:290	(8.00, -8.05, 12.86)
10:90074227		S>L	A:291	(13.60, -6.80, 11.79)
10:90045220		H>L	A:307	(-7.86, 6.06, 27.55)
10:90045218		H>Y	A:308	(-5.18, 9.98, 28.88)
10:90045203		A>P	A:313	(0.58, 3.49, 25.77)
10:90045194		G>R	A:316	(9.02, 1.91, 20.48)
10:90045191		D>N	A:317	(11.40, 0.30, 17.13)
10:90045151		S>F	A:330	(10.40, 5.60, 23.21)
10:90045143		C>G	A:333	(8.46, 9.86, 25.40)
10:90045136	rs544985084	L>P	A:335	(8.29, 8.43, 31.79)
10:90045127		L>S	A:338	(3.17, 8.41, 32.74)