Assessment of Structural Intolerance and Durability
General Structure Information 3tht ALKBH8 crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b 3.01Å AUTH C.PASTORE,I.TOPALIDOU,F.FOROUHAR,A.C.YAN,M.LEVY,J.F.HUNTTITL CRYSTAL STRUCTURE AND RNA BINDING PROPERTIES OF THE RNATITL 2 RECOGNITION MOTIF (RRM) AND ALKB DOMAINS IN HUMAN ALKBTITL 3 HOMOLOG 8 (ABH8), […]
General Structure Information 1ey2 HGD human homogentisate dioxygenase with fe(ii) 2.3Å AUTH G.P.TITUS,H.A.MUELLER,J.BURGNER,S.RODRIGUEZ DE CORDOBA,AUTH 2 M.A.PENALVA,D.E.TIMMTITL CRYSTAL STRUCTURE OF HUMAN HOMOGENTISATE DIOXYGENASE.REF NAT.STRUCT.BIOL. V. 7 542 2000REFN ISSN 1072-8368PMID 10876237DOI 10.1038/76756 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ahr ERO1L inactive human ero1 3.07Å AUTH K.INABA,S.MASUI,H.IIDA,S.VAVASSORI,R.SITIA,M.SUZUKITITL CRYSTAL STRUCTURES OF HUMAN ERO1-ALPHA REVEAL THE MECHANISMSTITL 2 OF REGULATED AND TARGETED OXIDATION OF PDIREF EMBO J. V. 29 3330 2010REFN ISSN 0261-4189PMID 20834232DOI 10.1038/EMBOJ.2010.222 Variant Set Distributions Mapped Variants
General Structure Information 2qq5 DHRS1 crystal structure of human sdr family member 1 1.8Å AUTH E.S.PILKA,V.HOZJAN,E.UGOCHUKWU,F.VON DELFT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN SDR FAMILY MEMBER 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1siq GCDH the crystal structure and mechanism of human glutaryl-coa dehydrogenase 2.1Å AUTH Z.FU,M.WANG,R.PASCHKE,K.S.RAO,F.E.FRERMAN,J.J.KIMTITL CRYSTAL STRUCTURES OF HUMAN GLUTARYL-COA DEHYDROGENASE WITHTITL 2 AND WITHOUT AN ALTERNATE SUBSTRATE: STRUCTURAL BASES OFTITL 3 DEHYDROGENATION AND DECARBOXYLATION REACTIONSREF BIOCHEMISTRY V. 43 9674 2004REFN ISSN 0006-2960PMID 15274622DOI 10.1021/BI049290C Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2pd6 HSD17B8 structure of human hydroxysteroid dehydrogenase type 8, hsd17b8 2.0Å AUTH A.P.TURNBULL,E.SALAH,O.GILEADI,P.SAVITSKY,K.GUO,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,J.WEIGELT,AUTH 3 C.H.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN HYDROXYSTEROID DEHYDROGENASE TYPE 8,TITL 2 HSD17B8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wek ZADH2 crystal structure of the human mgc45594 gene product in complex with diclofenac 1.9Å AUTH N.SHAFQAT,W.W.YUE,F.NIESEN,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT INTITL 2 COMPLEX WITH DICLOFENACREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dl2 UEVLD hexagonal structure of the ldh domain of human ubiquitin- conjugating enzyme e2-like isoform a 2.1Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,E.M.NEWMAN,AUTH 2 P.J.FINERTY JR.,C.BUTLER-COLE,C.BOUNTRA,AUTH 3 M.WOLKSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 S.DHE-PAGANONTITL STRUCTURAL INVESTIGATION INTO THE L-LACTATETITL 2 DEHYDROGENASE DOMAIN OF HUMANTITL 3 UBIQUITIN-CONJUGATING ENZYME E2-LIKE ISOFORM A.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2zb7 PTGR2 crystal structure of human 15-ketoprostaglandin delta-13- reductase in complex with nadph and nicotinamide 1.8Å AUTH Y.H.WU,T.P.KO,R.T.GUO,S.M.HU,L.M.CHUANG,A.H.J.WANGTITL STRUCTURAL BASIS FOR CATALYTIC AND INHIBITORYTITL 2 MECHANISMS OF HUMAN PROSTAGLANDIN REDUCTASE PTGR2.REF STRUCTURE V. 16 1714 2008REFN ISSN 0969-2126PMID 19000823DOI 10.1016/J.STR.2008.09.007 Variant Set Distributions Mapped Variants
General Structure Information 3cyn GPX8 the structure of human gpx8 2.0Å AUTH K.L.KAVANAGH,C.JOHANSSON,W.W.YUE,G.KOCHAN,U.OPPERMANNTITL THE STRUCTURE OF HUMAN GPX8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants