Assessment of Structural Intolerance and Durability
General Structure Information 3ggr RAD1 crystal structure of the human rad9-hus1-rad1 complex 3.2Å AUTH M.XU,L.BAI,Y.GONG,W.XIE,H.Y.HANG,T.JIANGTITL STRUCTURE AND FUNCTIONAL IMPLICATIONS OF THE HUMANTITL 2 RAD9-HUS1-RAD1 CELL CYCLE CHECKPOINT COMPLEXREF J.BIOL.CHEM. V. 284 20457 2009REFN ISSN 0021-9258PMID 19535328DOI 10.1074/JBC.C109.022384 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qs9 RBBP9 crystal structure of the human retinoblastoma-binding protein 9 (rbbp-9). nesg target hr2978 1.72Å AUTH S.M.VOROBIEV,M.SU,J.SEETHARAMAN,Y.J.HUANG,C.X.CHEN,AUTH 2 M.MAGLAQUI,H.JANJUA,M.PROUDFOOT,A.YAKUNIN,R.XIAO,AUTH 3 T.B.ACTON,G.T.MONTELIONE,L.TONGTITL CRYSTAL STRUCTURE OF HUMAN RETINOBLASTOMA BINDINGTITL 2 PROTEIN 9.REF PROTEINS V. 74 526 2008REFN ISSN 0887-3585PMID 19004028DOI 10.1002/PROT.22278 Variant Set Distributions Mapped Variants
General Structure Information 3fm0 CIAO1 crystal structure of wd40 protein ciao1 1.7Å AUTH C.XU,J.MINTITL STRUCTURE AND FUNCTION OF WD40 DOMAIN PROTEINS.REF PROTEIN CELL V. 2 202 2011REFN ISSN 1674-800XPMID 21468892DOI 10.1007/S13238-011-1018-1 Variant Set Distributions Mapped Variants
General Structure Information 3b4v FSTL3 x-ray structure of activin in complex with fstl3 2.48Å AUTH R.STAMLER,H.T.KEUTMANN,Y.SIDIS,C.KATTAMURI,A.SCHNEYER,AUTH 2 T.B.THOMPSONTITL THE STRUCTURE OF FSTL3.ACTIVIN A COMPLEX. DIFFERENTIALTITL 2 BINDING OF N-TERMINAL DOMAINS INFLUENCES FOLLISTATIN-TYPETITL 3 ANTAGONIST SPECIFICITY.REF J.BIOL.CHEM. V. 283 32831 2008REFN ISSN 0021-9258PMID 18768470DOI 10.1074/JBC.M801266200 Variant Set Distributions Mapped Variants
General Structure Information 2rpc ZIC3 solution structure of the tandem zf-c2h2 domains from the human zinc finger protein zic 3 -1.0Å AUTH M.HATAYAMA,T.TOMIZAWA,K.SAKAI-KATO,P.BOUVAGNET,AUTH 2 S.KOSE,N.IMAMOTO,S.YOKOYAMA,N.UTSUNOMIYA-TATE,AUTH 3 K.MIKOSHIBA,T.KIGAWA,J.ARUGATITL FUNCTIONAL AND STRUCTURAL BASIS OF THE NUCLEARTITL 2 LOCALIZATION SIGNAL IN THE ZIC3 ZINC FINGER DOMAINREF HUM.MOL.GENET. V. 17 3459 2008REFN ISSN 0964-6906PMID 18716025DOI 10.1093/HMG/DDN239 Variant Set Distributions […]
General Structure Information 3g65 HUS1 crystal structure of the human rad9-rad1-hus1 dna damage checkpoint complex 2.9Å AUTH A.S.DORE,M.L.KILKENNY,N.J.RZECHORZEK,L.H.PEARLTITL CRYSTAL STRUCTURE OF THE RAD9-RAD1-HUS1 DNA DAMAGETITL 2 CHECKPOINT COMPLEX–IMPLICATIONS FOR CLAMP LOADING ANDTITL 3 REGULATION.REF MOL.CELL V. 34 735 2009REFN ISSN 1097-2765PMID 19446481DOI 10.1016/J.MOLCEL.2009.04.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4f91 SNRNP200 brr2 helicase region 2.7Å AUTH K.F.SANTOS,S.M.JOVIN,G.WEBER,V.PENA,R.LUHRMANN,M.C.WAHLTITL STRUCTURAL BASIS FOR FUNCTIONAL COOPERATION BETWEEN TANDEMTITL 2 HELICASE CASSETTES IN BRR2-MEDIATED REMODELING OF THETITL 3 SPLICEOSOME.REF PROC.NATL.ACAD.SCI.USA V. 109 17418 2012REFN ISSN 0027-8424PMID 23045696DOI 10.1073/PNAS.1208098109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hu6 SPOP structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: spopmathx/btb/3-box-pucsbc1 2.7Å AUTH M.ZHUANG,M.F.CALABRESE,J.LIU,M.B.WADDELL,A.NOURSE,AUTH 2 M.HAMMEL,D.J.MILLER,H.WALDEN,D.M.DUDA,S.N.SEYEDIN,AUTH 3 T.HOGGARD,J.W.HARPER,K.P.WHITE,B.A.SCHULMANTITL STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTSTITL 2 INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITINTITL 3 LIGASES.REF MOL.CELL V. 36 39 2009REFN ISSN 1097-2765PMID 19818708DOI 10.1016/J.MOLCEL.2009.09.022 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3l6y CTNND1 crystal structure of p120 catenin in complex with e-cadherin 3.0Å AUTH N.ISHIYAMA,S.H.LEE,S.LIU,G.Y.LI,M.J.SMITH,L.F.REICHARDT,AUTH 2 M.IKURATITL DYNAMIC AND STATIC INTERACTIONS BETWEEN P120 CATENIN ANDTITL 2 E-CADHERIN REGULATE THE STABILITY OF CELL-CELL ADHESION.REF CELL(CAMBRIDGE,MASS.) V. 141 117 2010REFN ISSN 0092-8674PMID 20371349DOI 10.1016/J.CELL.2010.01.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3k27 EED complex structure of eed and trimethylated h3k9 1.76Å AUTH C.XU,C.BIAN,W.YANG,M.GALKA,H.OUYANG,C.CHEN,W.QIU,H.LIU,AUTH 2 A.E.JONES,F.MACKENZIE,P.PAN,S.S.LI,H.WANG,J.MINTITL BINDING OF DIFFERENT HISTONE MARKS DIFFERENTIALLY REGULATESTITL 2 THE ACTIVITY AND SPECIFICITY OF POLYCOMB REPRESSIVE COMPLEXTITL 3 2 (PRC2).REF PROC.NATL.ACAD.SCI.USA V. 107 19266 2010REFN ISSN 0027-8424PMID 20974918DOI 10.1073/PNAS.1008937107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]