Assessment of Structural Intolerance and Durability
General Structure Information 3epp RNMT crystal structure of mrna cap guanine-n7 methyltransferase (rnmt) in complex with sinefungin 2.41Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASETITL 2 (RNMT) IN COMPLEX WITH SINEFUNGIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4f9a CDC7 human cdc7 kinase in complex with dbf4 and nucleotide 2.17Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k86 FOXO3 solution structure of foxo3a forkhead domain -1.0Å AUTH F.WANG,C.B.MARSHALL,K.YAMAMOTO,G.Y.LI,M.J.PLEVIN,AUTH 2 H.YOU,T.W.MAK,M.IKURATITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF ANTITL 2 INTRAMOLECULAR INTERACTION IN FOXO3A AND ITSTITL 3 BINDING WITH P53.REF J.MOL.BIOL. V. 384 590 2008REFN ISSN 0022-2836PMID 18824006DOI 10.1016/J.JMB.2008.09.025 Variant Set Distributions Mapped Variants
General Structure Information 2zfu RRP8 structure of the methyltransferase-like domain of nucleomethylin 2.0Å AUTH A.MURAYAMA,K.OHMORI,A.FUJIMURA,H.MINAMI,K.YASUZAWA-TANAKA,AUTH 2 T.KURODA,S.OIE,H.DAITOKU,M.OKUWAKI,K.NAGATA,A.FUKAMIZU,AUTH 3 K.KIMURA,T.SHIMIZU,J.YANAGISAWATITL EPIGENETIC CONTROL OF RDNA LOCI IN RESPONSE TO INTRACELLULARTITL 2 ENERGY STATUSREF CELL(CAMBRIDGE,MASS.) V. 133 627 2008REFN ISSN 0092-8674PMID 18485871DOI 10.1016/J.CELL.2008.03.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3geb EYA2 crystal structure of edeya2 2.4Å AUTH S.J.KIM,D.G.JEONG,S.K.JUNG,E.R.SEONGTITL STRUCTURE OF EDEYA2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hdo KRIT1 crystal structure of the binary complex of krit1 bound to the rap1 gtpase 1.67Å AUTH A.R.GINGRAS,W.PUZON-MCLAUGHLIN,M.H.GINSBERGTITL THE STRUCTURE OF THE TERNARY COMPLEX OF KREV INTERACTIONTITL 2 TRAPPED 1 (KRIT1) BOUND TO BOTH THE RAP1 GTPASE AND THETITL 3 HEART OF GLASS (HEG1) CYTOPLASMIC TAIL.REF J.BIOL.CHEM. V. 288 23639 2013REFN ISSN […]
General Structure Information 2r5t SGK1 crystal structure of inactive serum and glucocorticoid- regulated kinase 1 in complex with amp-pnp 1.9Å AUTH B.ZHAO,R.LEHR,A.M.SMALLWOOD,T.F.HO,K.MALEY,AUTH 2 T.RANDALL,M.S.HEAD,K.K.KORETKE,C.G.SCHNACKENBERGTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF SERUMTITL 2 AND GLUCOCORTICOID-REGULATED KINASE 1 IN COMPLEXTITL 3 WITH AMP PNP.REF PROTEIN SCI. V. 16 2761 2007REFN ISSN 0961-8368PMID 17965184DOI 10.1110/PS.073161707 Variant Set […]
General Structure Information 3fdl BCL2L11 bim bh3 peptide in complex with bcl-xl 1.78Å AUTH E.F.LEE,J.D.SADOWSKY,B.J.SMITH,P.E.CZABOTAR,AUTH 2 K.J.PETERSON-KAUFMAN,P.M.COLMAN,S.H.GELLMAN,AUTH 3 W.D.FAIRLIETITL HIGH-RESOLUTION STRUCTURAL CHARACTERIZATION OF ATITL 2 HELICAL ALPHA/BETA-PEPTIDE FOLDAMER BOUND TO THETITL 3 ANTI-APOPTOTIC PROTEIN BCL-X(L)REF ANGEW.CHEM.INT.ED.ENGL. V. 48 4318 2009REFN ISSN 1433-7851PMID 19229915DOI 10.1002/ANIE.200805761 Variant Set Distributions Mapped Variants