Assessment of Structural Intolerance and Durability
General Structure Information 3dal PRDM1 methyltransferase domain of human pr domain-containing protein 1 1.65Å AUTH H.ZENG,M.F.AMAYA,T.ANTOSHENKO,A.DONG,P.LOPPNAU,AUTH 2 A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lju ADAP1 crystal structure of full length centaurin alpha-1 bound with the head group of pip3 1.7Å AUTH Y.TONG,W.TEMPEL,H.WANG,K.YAMADA,L.SHEN,G.A.SENISTERRA,AUTH 2 F.MACKENZIE,A.H.CHISHTI,H.W.PARKTITL PHOSPHORYLATION-INDEPENDENT DUAL-SITE BINDING OF THE FHATITL 2 DOMAIN OF KIF13 MEDIATES PHOSPHOINOSITIDE TRANSPORT VIATITL 3 CENTAURIN ALPHA1.REF PROC.NATL.ACAD.SCI.USA V. 107 20346 2010REFN ISSN 0027-8424PMID 21057110DOI 10.1073/PNAS.1009008107 Variant Set Distributions Ripley’s K […]
General Structure Information 2k1p ZRANB2 solution structure of the second zinc finger domain of zranb2/znf265 -1.0Å AUTH F.E.LOUGHLIN,R.E.MANSFIELD,P.M.VAZ,W.LEUNG,AUTH 2 S.SETIYAPUTRA,R.P.GRANT,E.S.CHEN,R.GAMSJAEGER,AUTH 3 J.P.MACKAYTITL THE ZINC FINGERS OF THE SR-PROEIN ZRANB2 RECOGNIZETITL 2 5SPLICE SITE-LIKE SEQUENCES AND CONSTITUTE ATITL 3 DISTINCT CLASS OF RNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wvr GMNN human cdt1:geminin complex 3.3Å AUTH V.DE MARCO,P.J.GILLESPIE,A.LI,N.KARANTZELIS,AUTH 2 E.CHRISTODOULOU,R.KLOMPMAKER,S.VAN GERWEN,A.FISH,AUTH 3 M.V.PETOUKHOV,M.S.ILIOU,Z.LYGEROU,R.H.MEDEMA,AUTH 4 J.J.BLOW,D.I.SVERGUN,S.TARAVIRAS,A.PERRAKISTITL QUATERNARY STRUCTURE OF THE HUMAN CDT1-GEMININTITL 2 COMPLEX REGULATES DNA REPLICATION LICENSING.REF PROC.NATL.ACAD.SCI.USA V. 106 19807 2009REFN ISSN 0027-8424PMID 19906994DOI 10.1073/PNAS.0905281106 Variant Set Distributions Mapped Variants
General Structure Information 3h7h SUPT5H crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273) 1.55Å AUTH S.WENZEL,B.M.MARTINS,P.ROSCH,B.M.WOHRLTITL CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION ELONGATIONTITL 2 FACTOR DSIF HSPT4 SUBUNIT IN COMPLEX WITH THE HSPT5TITL 3 DIMERIZATION INTERFACEREF BIOCHEM.J. V. 425 373 2010REFN ISSN 0264-6021PMID 19860741DOI 10.1042/BJ20091422 Variant Set Distributions Mapped Variants
General Structure Information 2vpd BCL9 decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex 2.77Å AUTH M.FIEDLER,M.J.SANCHEZ-BARRENA,M.NEKRASOV,AUTH 2 J.MIESZCZANEK,V.RYBIN,J.MULLER,P.EVANS,M.BIENZTITL DECODING OF METHYLATED HISTONE H3 TAIL BY THETITL 2 PYGO- BCL9 WNT SIGNALING COMPLEX.REF MOL.CELL V. 30 507 2008REFN ISSN 1097-2765PMID 18498752DOI 10.1016/J.MOLCEL.2008.03.011 Variant Set Distributions Mapped Variants
General Structure Information 3bqr DAPK3 crystal structure of human death associated protein kinase 3 (dapk3) in complex with an imidazo-pyridazine ligand 1.75Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,O.FEDOROV,F.NIESEN,A.C.W.PIKE,AUTH 2 E.S.PILKA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3TITL 2 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3hfh TCERG1 crystal structure of tandem ff domains 2.7Å AUTH M.LU,J.YANG,Z.REN,S.SABUI,A.ESPEJO,M.T.BEDFORD,AUTH 2 R.H.JACOBSON,D.JERUZALMI,J.S.MCMURRAY,X.CHENTITL CRYSTAL STRUCTURE OF THE THREE TANDEM FF DOMAINS OFTITL 2 THE TRANSCRIPTION ELONGATION REGULATOR CA150.REF J.MOL.BIOL. V. 393 397 2009REFN ISSN 0022-2836PMID 19660470DOI 10.1016/J.JMB.2009.07.086 Variant Set Distributions Mapped Variants
General Structure Information 2r0o ACTN4 crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(k255e) 2.2Å AUTH S.H.LEE,A.WEINS,D.B.HAYES,M.R.POLLAK,R.DOMINGUEZTITL CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OFTITL 2 ALPHA-ACTININ-4 LYS255GLU MUTANT IMPLICATED IN FOCALTITL 3 SEGMENTAL GLOMERULOSCLEROSIS.REF J.MOL.BIOL. V. 376 317 2008REFN ISSN 0022-2836PMID 18164029DOI 10.1016/J.JMB.2007.11.084 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gb8 XPO1 crystal structure of crm1/snurportin-1 complex 2.9Å AUTH X.DONG,A.BISWAS,K.E.SUEL,L.K.JACKSON,R.MARTINEZ,H.GU,AUTH 2 Y.M.CHOOKTITL STRUCTURAL BASIS FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALTITL 2 RECOGNITION BY CRM1.REF NATURE V. 458 1136 2009REFN ISSN 0028-0836PMID 19339969DOI 10.1038/NATURE07975 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants