3FM0.A | CIAO1

General Structure Information

PDB ID	3fm0
HGNC Gene Label(s)	CIAO1
Structure Name	crystal structure of wd40 protein ciao1
Resolution	1.7Å
Reference	AUTH C.XU,J.MINTITL STRUCTURE AND FUNCTION OF WD40 DOMAIN PROTEINS.REF PROTEIN CELL V. 2 202 2011REFN ISSN 1674-800XPMID 21468892DOI 10.1007/S13238-011-1018-1

Variant Set Distributions

ExAC Variants

Number Of Residues	328
Number Of SNVs	77
Number Of Permutations	25030
Optimal Distance Threshold	14.0
K Statistic	0.129
p-value	0.269

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:96932144	rs199793823	C>S	A:19	(12.71, 40.75, 36.28)
2:96932156		A>G	A:23	(19.52, 32.00, 39.66)
2:96932165	rs549269750	P>L	A:26	(25.31, 24.91, 40.87)
2:96932171		G>E	A:28	(26.58, 27.62, 35.37)
2:96932186		S>L	A:33	(14.05, 33.96, 35.55)
2:96932226		E>D	A:46	(21.17, 27.30, 22.25)
2:96933063	rs371093340	D>E	A:48	(25.72, 33.27, 19.68)
2:96933073		C>G	A:52	(14.41, 29.64, 26.78)
2:96933080	rs141372500	S>F	A:54	(12.64, 25.99, 30.24)
2:96933082		V>I	A:55	(8.65, 27.81, 30.60)
2:96933097		H>Y	A:60	(3.19, 30.01, 41.45)
2:96933098	rs572279152	H>L	A:60	(3.19, 30.01, 41.45)
2:96933109		V>M	A:64	(7.58, 34.68, 41.03)
2:96933112	rs11544859	R>W	A:65	(10.57, 39.00, 44.42)
2:96933136	rs142959894	G>S	A:73	(20.66, 21.19, 40.84)
2:96933172		T>P	A:85	(7.14, 27.92, 47.95)
2:96933173	rs368147686	T>S	A:85	(7.14, 27.92, 47.95)
2:96933177		C>W	A:86	(6.98, 25.97, 44.39)
2:96933370		T>I	A:99	(5.95, 20.67, 45.97)
2:96933372		T>S	A:100	(3.19, 23.32, 47.11)
2:96933373		T>I	A:100	(3.19, 23.32, 47.11)
2:96933376		L>R	A:101	(5.92, 24.80, 50.39)
2:96933378		E>K	A:102	(0.72, 25.31, 51.63)
2:96933391		N>S	A:106	(0.98, 37.03, 53.91)
2:96933397		V>G	A:108	(6.60, 34.51, 49.74)
2:96933400		K>T	A:109	(8.86, 38.63, 49.68)
2:96933401		K>N	A:109	(8.86, 38.63, 49.68)
2:96933409		A>V	A:112	(16.87, 29.38, 50.52)
2:96933423		G>S	A:117	(19.72, 19.96, 51.21)
2:96933459	rs376328095	V>F	A:129	(11.70, 32.94, 58.71)
2:96933582		E>K	A:137	(9.62, 9.95, 50.41)
2:96933585		D>N	A:138	(10.07, 14.63, 48.88)
2:96933586		D>G	A:138	(10.07, 14.63, 48.88)
2:96933588		E>Q	A:139	(7.57, 14.17, 52.26)
2:96933600		V>F	A:143	(11.19, 22.46, 61.48)
2:96933609	COSM1023858	L>F	A:146	(12.24, 31.99, 62.74)
2:96933610		L>H	A:146	(12.24, 31.99, 62.74)
2:96933613	rs377428847	N>S	A:147	(8.25, 35.42, 64.28)
2:96933628		D>V	A:152	(8.42, 42.70, 55.20)
2:96933658	rs373437838	Q>R	A:162	(28.23, 26.68, 58.14)
2:96933660	rs201951574	E>Q	A:163	(23.33, 24.19, 58.10)
2:96934213		Y>N	A:170	(10.30, 47.92, 56.37)
2:96934218		D>E	A:171	(13.38, 45.34, 60.92)
2:96934238	rs377203527	R>Q	A:178	(23.34, 28.62, 65.84)
2:96934258		V>I	A:185	(18.12, 29.92, 67.64)
2:96934265	rs368621207	C>Y	A:187	(22.49, 33.84, 66.79)
2:96934267		A>T	A:188	(22.16, 37.35, 65.59)
2:96934268		A>V	A:188	(22.16, 37.35, 65.59)
2:96934316	rs199846474	P>Q	A:204	(34.34, 33.92, 49.68)
2:96934327		R>C	A:208	(33.64, 38.67, 55.10)
2:96934328		R>H	A:208	(33.64, 38.67, 55.10)
2:96934334		A>V	A:210	(26.81, 41.60, 52.78)
2:96934342	rs571238881	S>G	A:213	(19.83, 49.46, 52.12)
2:96934345		D>N	A:214	(16.43, 52.46, 51.35)
2:96934351		R>C	A:216	(20.73, 55.90, 49.17)
2:96934352	rs142522111	R>H	A:216	(20.73, 55.90, 49.17)
2:96934360		R>C	A:219	(26.60, 48.31, 57.31)
2:96934375		Y>H	A:224	(34.68, 38.62, 65.06)
2:96934388	rs140260270	N>S	A:228	(38.54, 36.69, 68.95)
2:96935011		A>S	A:233	(32.76, 39.75, 72.85)
2:96935029	rs150250572	P>A	A:239	(29.39, 33.32, 67.43)
2:96935041		C>R	A:243	(30.38, 46.37, 61.25)
2:96935043		C>W	A:243	(30.38, 46.37, 61.25)
2:96935044	rs72937663	I>V	A:244	(34.22, 45.42, 59.33)
2:96935045		I>T	A:244	(34.22, 45.42, 59.33)
2:96935066		H>L	A:251	(25.09, 53.38, 46.01)
2:96935077		I>V	A:255	(21.01, 49.20, 47.34)
2:96936856		L>M	A:263	(34.95, 32.24, 42.23)
2:96936863		G>E	A:265	(35.03, 38.78, 45.61)
2:96936865	rs374736407	A>S	A:266	(33.46, 40.50, 43.56)
2:96936872		A>V	A:268	(27.76, 43.46, 43.08)
2:96936874		T>S	A:269	(25.53, 46.63, 43.42)
2:96936892	rs367694646	A>T	A:275	(23.14, 50.92, 38.03)
2:96936893		A>V	A:275	(23.14, 50.92, 38.03)
2:96936898		R>C	A:277	(27.21, 50.82, 41.28)
2:96936901	rs371499283	V>L	A:278	(31.76, 46.33, 40.82)
2:96936920		N>S	A:284	(47.35, 46.08, 50.57)
2:96936938		P>R	A:290	(37.95, 46.65, 55.46)
2:96936940		T>A	A:291	(39.17, 49.29, 52.13)
2:96936958		H>Y	A:297	(29.14, 53.43, 37.75)
2:96936974		H>P	A:302	(19.18, 47.31, 32.90)
2:96936989	rs191488251	N>S	A:307	(15.56, 44.15, 40.73)
2:96937007		P>L	A:313	(29.07, 29.69, 39.89)
2:96937027		A>T	A:320	(23.64, 38.46, 35.78)
2:96937028		A>V	A:320	(23.64, 38.46, 35.78)
2:96937040		D>G	A:324	(11.53, 46.77, 36.88)
2:96937042		D>N	A:325	(12.95, 46.36, 31.71)
2:96937066		Y>H	A:333	(34.55, 42.55, 36.49)
2:96937069		Q>E	A:334	(36.64, 43.20, 32.20)
2:96937072	rs139155173	R>W	A:335	(39.19, 43.82, 36.90)
2:96937073	rs199858380	R>Q	A:335	(39.19, 43.82, 36.90)