General Structure Information 1djl NNT the crystal structure of human transhydrogenase domain iii with bound nadp 2.0Å AUTH S.A.WHITE,S.J.PEAKE,S.MCSWEENEY,G.LEONARD,N.P.COTTON,AUTH 2 J.B.JACKSONTITL THE HIGH-RESOLUTION STRUCTURE OF THE NADP(H)-BINDINGTITL 2 COMPONENT (DIII) OF PROTON-TRANSLOCATING TRANSHYDROGENASETITL 3 FROM HUMAN HEART MITOCHONDRIA.REF STRUCTURE FOLD.DES. V. 8 1 2000REFN ISSN 0969-2126PMID 10673423DOI 10.1016/S0969-2126(00)00075-7 Variant Set Distributions Mapped Variants
General Structure Information 3caq AKR1D1 crystal structure of 5beta-reductase (akr1d1) in complex with nadph 2.2Å AUTH F.FAUCHER,L.CANTIN,V.LUU-THE,F.LABRIE,R.BRETONTITL CRYSTAL STRUCTURES OF HUMAN DELTA4-3-KETOSTEROIDTITL 2 5BETA-REDUCTASE (AKR1D1) REVEAL THE PRESENCE OF ANTITL 3 ALTERNATIVE BINDING SITE RESPONSIBLE FOR SUBSTRATETITL 4 INHIBITION (DAGGER) (,) (DOUBLE DAGGER).REF BIOCHEMISTRY V. 47 13537 2008REFN ISSN 0006-2960PMID 19075558DOI 10.1021/BI801276H Variant Set Distributions […]
General Structure Information 3hhd FASN structure of the human fatty acid synthase ks-mat didomain as a framework for inhibitor design. 2.15Å AUTH G.PAPPENBERGER,J.BENZ,B.GSELL,M.HENNIG,A.RUF,AUTH 2 M.STIHLE,R.THOMA,M.G.RUDOLPHTITL STRUCTURE OF THE HUMAN FATTY ACID SYNTHASE KS-MATTITL 2 DIDOMAIN AS A FRAMEWORK FOR INHIBITOR DESIGN.REF J.MOL.BIOL. V. 397 508 2010REFN ISSN 0022-2836PMID 20132826DOI 10.1016/J.JMB.2010.01.066 Variant Set Distributions Ripley’s K […]
General Structure Information 2jkv PGD structure of human phosphogluconate dehydrogenase in complex with nadph at 2.53a 2.53Å AUTH S.S.NG,F.VON DELFT,E.S.PILKA,K.L.KAVANAGH,M.A.MCDONOUGH,AUTH 2 P.SAVITSKY,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,M.SUNDSTROM,AUTH 3 C.J.SCHOFIELD,U.OPPERMANNTITL STRUCTURE OF HUMAN PHOSPHOGLUCONATE DEHYDROGENASE INTITL 2 COMPLEX WITH NADPH AT 2.53AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hr4 NOS2 human inos reductase and calmodulin complex 2.5Å AUTH C.XIA,I.MISRA,T.IYANAKI,J.J.K.KIMTITL REGULATION OF INTERDOMAIN INTERACTIONS BY CAM IN INDUCIBLETITL 2 NITRIC OXIDE SYNTHASEREF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 3e7g NOS2 structure of human inosox with inhibitor ar-c95791 2.2Å AUTH E.D.GARCIN,A.S.ARVAI,R.J.ROSENFELD,M.D.KROEGER,AUTH 2 B.R.CRANE,G.ANDERSSON,G.ANDREWS,P.J.HAMLEY,AUTH 3 P.R.MALLINDER,D.J.NICHOLLS,S.A.ST-GALLAY,AUTH 4 A.C.TINKER,N.P.GENSMANTEL,A.METE,D.R.CHESHIRE,AUTH 5 S.CONNOLLY,D.J.STUEHR,A.ABERG,A.V.WALLACE,AUTH 6 J.A.TAINER,E.D.GETZOFFTITL ANCHORED PLASTICITY OPENS DOORS FOR SELECTIVETITL 2 INHIBITOR DESIGN IN NITRIC OXIDE SYNTHASE.REF NAT.CHEM.BIOL. V. 4 700 2008REFN ISSN 1552-4450PMID 18849972DOI 10.1038/NCHEMBIO.115 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2irw HSD11B1 human 11-beta-hydroxysteroid dehydrogenase (hsd1) with nadp and adamantane ether inhibitor 3.1Å AUTH J.R.PATEL,Q.SHUAI,J.DINGES,M.WINN,M.PLIUSHCHEV,S.FUNG,AUTH 2 K.MONZON,W.CHIOU,J.WANG,L.PAN,S.WAGAW,K.ENGSTROM,AUTH 3 F.A.KERDESKY,K.LONGENECKER,R.JUDGE,W.QIN,H.M.IMADE,AUTH 4 D.STOLARIK,D.W.BENO,M.BRUNE,L.E.CHOVAN,H.L.SHAM,P.JACOBSON,AUTH 5 J.T.LINKTITL DISCOVERY OF ADAMANTANE ETHERS AS INHIBITORS OFTITL 2 11BETA-HSD-1: SYNTHESIS AND BIOLOGICAL EVALUATION.REF BIOORG.MED.CHEM.LETT. V. 17 750 2007REFN ISSN 0960-894XPMID 17110106DOI 10.1016/J.BMCL.2006.10.074 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bhm CBR1 crystal structure of human carbonyl reductase 1 in complex with s-hydroxymethylglutathione 1.8Å AUTH R.L.BATEMAN,D.RAUH,B.TAVSHANJIAN,K.M.SHOKATTITL HUMAN CARBONYL REDUCTASE 1 IS ANTITL 2 S-NITROSOGLUTATHIONE REDUCTASEREF J.BIOL.CHEM. V. 283 35756 2008REFN ISSN 0021-9258PMID 18826943DOI 10.1074/JBC.M807125200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1dig MTHFD1 human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly374571 2.2Å AUTH A.SCHMIDT,H.WU,R.E.MACKENZIE,V.J.CHEN,J.R.BEWLY,AUTH 2 J.E.RAY,J.E.TOTH,M.CYGLERTITL STRUCTURES OF THREE INHIBITOR COMPLEXES PROVIDETITL 2 INSIGHT INTO THE REACTION MECHANISM OF THE HUMANTITL 3 METHYLENETETRAHYDROFOLATETITL 4 DEHYDROGENASE/CYCLOHYDROLASE.REF BIOCHEMISTRY V. 39 6325 2000REFN ISSN 0006-2960PMID 10828945DOI 10.1021/BI992734Y Variant Set Distributions Mapped Variants
General Structure Information 1t0l IDH1 crystal structure of human cytosolic nadp(+)-dependent isocitrate dehydrogenase in complex with nadp, isocitrate, and calcium(2+) 2.41Å AUTH X.XU,J.ZHAO,Z.XU,B.PENG,Q.HUANG,E.ARNOLD,J.DINGTITL STRUCTURES OF HUMAN CYTOSOLIC NADP-DEPENDENTTITL 2 ISOCITRATE DEHYDROGENASE REVEAL A NOVELTITL 3 SELF-REGULATORY MECHANISM OF ACTIVITYREF J.BIOL.CHEM. V. 279 33946 2004REFN ISSN 0021-9258PMID 15173171DOI 10.1074/JBC.M404298200 Variant Set Distributions Ripley’s K Analysis Plots […]