General Structure Information
| PDB ID | 3caq |
| HGNC Gene Label(s) | AKR1D1 |
| Structure Name | crystal structure of 5beta-reductase (akr1d1) in complex with nadph |
| Resolution | 2.2Å |
| Reference | AUTH F.FAUCHER,L.CANTIN,V.LUU-THE,F.LABRIE,R.BRETONTITL CRYSTAL STRUCTURES OF HUMAN DELTA4-3-KETOSTEROIDTITL 2 5BETA-REDUCTASE (AKR1D1) REVEAL THE PRESENCE OF ANTITL 3 ALTERNATIVE BINDING SITE RESPONSIBLE FOR SUBSTRATETITL 4 INHIBITION (DAGGER) (,) (DOUBLE DAGGER).REF BIOCHEMISTRY V. 47 13537 2008REFN ISSN 0006-2960PMID 19075558DOI 10.1021/BI801276H |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 324 |
| Number Of SNVs | 95 |
| Number Of Permutations | 11006 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.022 |
| p-value | 0.856 |
ClinVar
| Number Of Residues | 324 |
| Number Of SNVs | 4 |
| Number Of Permutations | 314 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.0 |
| p-value | 1.0 |
COSMIC
| Number Of Residues | 324 |
| Number Of SNVs | 7 |
| Number Of Permutations | 2109 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.048 |
| p-value | 0.617 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 95 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.092 |
| p-value | 1.0 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 95 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.184 |
| p-value | 0.224 |