Assessment of Structural Intolerance and Durability
General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c6q GMPR2 crystal structure of human guanosine monophosphate reductase 2 gmpr2 in complex with imp and nadph 1.7Å AUTH G.C.PATTON,P.STENMARK,D.R.GOLLAPALLI,R.SEVASTIK,P.KURSULA,AUTH 2 S.FLODIN,H.SCHULER,C.T.SWALES,H.EKLUND,F.HIMO,P.NORDLUND,AUTH 3 L.HEDSTROMTITL COFACTOR MOBILITY DETERMINES REACTION OUTCOME IN THE IMPDHTITL 2 AND GMPR (BETA-ALPHA)(8) BARREL ENZYMES.REF NAT.CHEM.BIOL. V. 7 950 2011REFN ISSN 1552-4450PMID 22037469DOI 10.1038/NCHEMBIO.693 Variant Set Distributions Mapped Variants
General Structure Information 2vcy MECR crystal structure of 2-enoyl thioester reductase of human fas ii 2.41Å AUTH Z.J.CHEN,R.PUDAS,S.SHARMA,O.S.SMART,A.H.JUFFER,AUTH 2 J.K.HILTUNEN,R.K.WIERENGA,A.M.HAAPALAINENTITL STRUCTURAL ENZYMOLOGICAL STUDIES OF 2-ENOYLTITL 2 THIOESTER REDUCTASE OF THE HUMAN MITOCHONDRIAL FASTITL 3 II PATHWAY: NEW INSIGHTS INTO ITS SUBSTRATETITL 4 RECOGNITION PROPERTIES.REF J.MOL.BIOL. V. 379 830 2008REFN ISSN 0022-2836PMID 18479707DOI 10.1016/J.JMB.2008.04.041 Variant Set […]
General Structure Information 2wek ZADH2 crystal structure of the human mgc45594 gene product in complex with diclofenac 1.9Å AUTH N.SHAFQAT,W.W.YUE,F.NIESEN,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT INTITL 2 COMPLEX WITH DICLOFENACREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zb7 PTGR2 crystal structure of human 15-ketoprostaglandin delta-13- reductase in complex with nadph and nicotinamide 1.8Å AUTH Y.H.WU,T.P.KO,R.T.GUO,S.M.HU,L.M.CHUANG,A.H.J.WANGTITL STRUCTURAL BASIS FOR CATALYTIC AND INHIBITORYTITL 2 MECHANISMS OF HUMAN PROSTAGLANDIN REDUCTASE PTGR2.REF STRUCTURE V. 16 1714 2008REFN ISSN 0969-2126PMID 19000823DOI 10.1016/J.STR.2008.09.007 Variant Set Distributions Mapped Variants
General Structure Information 1w6u DECR1 structure of human decr ternary complex 1.75Å AUTH M.S.ALPHEY,W.YU,E.BYRES,D.LI,W.N.HUNTERTITL STRUCTURE AND REACTIVITY OF HUMAN MITOCHONDRIALTITL 2 2,4-DIENOYL-COA REDUCTASE: ENZYME-LIGANDTITL 3 INTERACTIONS IN A DISTINCTIVE SHORT-CHAINTITL 4 REDUCTASE ACTIVE SITEREF J.BIOL.CHEM. V. 280 3068 2005REFN ISSN 0021-9258PMID 15531764DOI 10.1074/JBC.M411069200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2cfy TXNRD1 crystal structure of human thioredoxin reductase 1 2.7Å AUTH J.E.DEBRECZENI,C.JOHANSSON,K.KAVANAGH,P.SAVITSKY,AUTH 2 M.SUNDSTROM,C.ARROWSMITH,J.WEIGELT,A.EDWARDS,F.VON DELFT,AUTH 3 U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ld6 CYP51A1 crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole 2.8Å AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kvo HSDL2 crystal structure of the catalytic domain of human hydroxysteroid dehydrogenase like 2 (hsdl2) 2.25Å AUTH E.UGOCHUKWU,C.BHATIA,J.HUANG,E.PILKA,J.R.C.MUNIZ,A.C.W.PIKE,AUTH 2 T.KROJER,F.VON DELFT,E.M.VERDIN,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 HYDROXYSTEROID DEHYDROGENASE LIKE 2 (HSDL2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]