Assessment of Structural Intolerance and Durability
General Structure Information 4eku PTK2B crystal structure of ferm domain of proline-rich tyrosine kinase 2 3.25Å AUTH B.SAVARIMUTHU,R.LI,Y.WANGTITL CRYSTAL STRUCTURE OF THE FERM DOMAIN OF PROLINE-RICHTITL 2 TYROSINE KINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4iir PRPF4B crystal structure of amppnp-bound human prpf4b kinase domain 2.0Å AUTH Q.GAO,I.MECHIN,N.KOTHARI,Z.GUO,G.DENG,K.HAAS,J.MCMANUS,AUTH 2 D.HOFFMANN,A.WANG,D.WIEDERSCHAIN,J.ROCNIK,W.CZECHTIZKY,AUTH 3 X.CHEN,L.MCLEAN,H.ARLT,D.HARPER,F.LIU,T.MAJID,V.PATEL,AUTH 4 C.LENGAUER,C.GARCIA-ECHEVERRIA,B.ZHANG,H.CHENG,M.DORSCH,AUTH 5 S.M.HUANGTITL EVALUATION OF CANCER DEPENDENCE AND DRUGGABILITY OF PRP4TITL 2 KINASE USING CELLULAR, BIOCHEMICAL, AND STRUCTURALTITL 3 APPROACHES.REF J.BIOL.CHEM. V. 288 30125 2013REFN ISSN 0021-9258PMID 24003220DOI 10.1074/JBC.M113.473348 Variant Set Distributions Ripley’s K […]
General Structure Information 2qlu ACVR2B crystal structure of activin receptor type ii kinase domain from human 2.0Å AUTH S.HAN,P.LOULAKIS,M.GRIFFOR,Z.XIETITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE IIBTITL 2 KINASE DOMAIN FROM HUMAN AT 2.0 ANGSTROM RESOLUTIONREF PROTEIN SCI. V. 16 2272 2007REFN ISSN 0961-8368PMID 17893364DOI 10.1110/PS.073068407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4mq2 DYRK1A the crystal structure of dyrk1a with a bound pyrido[2,3-d]pyrimidine inhibitor 2.8Å AUTH K.ANDERSON,Y.CHEN,Z.CHEN,R.DOMINIQUE,K.GLENN,Y.HE,C.JANSON,AUTH 2 K.C.LUK,C.LUKACS,A.POLONSKAIA,Q.QIAO,A.RAILKAR,P.ROSSMAN,AUTH 3 H.SUN,Q.XIANG,M.VILENCHIK,P.WOVKULICH,X.ZHANGTITL PYRIDO[2,3-D]PYRIMIDINES: DISCOVERY AND PRELIMINARY SAR OF ATITL 2 NOVEL SERIES OF DYRK1B AND DYRK1A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 6610 2013REFN ISSN 0960-894XPMID 24239188DOI 10.1016/J.BMCL.2013.10.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1s1c ROCK1 crystal structure of the complex between the human rhoa and rho-binding domain of human rocki 2.6Å AUTH R.DVORSKY,L.BLUMENSTEIN,I.R.VETTER,M.R.AHMADIANTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF ROCKITITL 2 WITH THE SWITCH REGIONS OF RHOA.REF J.BIOL.CHEM. V. 279 7098 2004REFN ISSN 0021-9258PMID 14660612DOI 10.1074/JBC.M311911200 Variant Set Distributions Mapped Variants
General Structure Information 3ogj PRKG1 crystal structure of partial apo (92-227) of cgmp-dependent protein kinase 2.75Å AUTH J.J.KIM,D.E.CASTEEL,G.HUANG,T.H.KWON,R.K.REN,P.ZWART,AUTH 2 J.J.HEADD,N.G.BROWN,D.C.CHOW,T.PALZKILL,C.KIMTITL CO-CRYSTAL STRUCTURES OF PKG IBETA (92-227) WITH CGMP ANDTITL 2 CAMP REVEAL THE MOLECULAR DETAILS OF CYCLIC-NUCLEOTIDETITL 3 BINDINGREF PLOS ONE V. 6 E1841 2011REFN ESSN 1932-6203PMID 21526164DOI 10.1371/JOURNAL.PONE.0018413 Variant Set Distributions Mapped Variants
General Structure Information 3ch4 PMVK the crystal structure of human phosphomavelonate kinase at 1.8 a resolution 1.76Å AUTH Q.CHANG,X.-X.YAN,S.-Y.GU,J.-F.LIU,D.-C.LIANGTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHOMAVELONATETITL 2 KINASE AT 1.8 A RESOLUTIONREF PROTEINS V. 73 254 2008REFN ISSN 0887-3585PMID 18618710DOI 10.1002/PROT.22151 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1y8p PDK3 crystal structure of the pdk3-l2 complex 2.63Å AUTH M.KATO,J.L.CHUANG,S.C.TSO,R.M.WYNN,D.T.CHUANGTITL CRYSTAL STRUCTURE OF PYRUVATE DEHYDROGENASE KINASE 3 BOUNDTITL 2 TO LIPOYL DOMAIN 2 OF HUMAN PYRUVATE DEHYDROGENASE COMPLEX.REF EMBO J. V. 24 1763 2005REFN ISSN 0261-4189PMID 15861126DOI 10.1038/SJ.EMBOJ.7600663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3bhh CAMK2B crystal structure of human calcium/calmodulin-dependent protein kinase iib isoform 1 (camk2b) 2.4Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,F.NIESEN,N.BURGESS,A.BULLOCK,AUTH 2 G.BERRIDGE,A.C.W.PIKE,E.UGOCHUKWU,E.S.PILKA,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE IIB ISOFORM 1 (CAMK2B).REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3h8m EPHA7 sam domain of human ephrin type-a receptor 7 (epha7) 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants