Assessment of Structural Intolerance and Durability
General Structure Information 2edr OBSCN solution structure of the ig-like domain (3361-3449) of human obscurin -1.0Å AUTH C.KUROSAKI,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IG-LIKE DOMAINTITL 2 (3361-3449) OF HUMAN OBSCURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3v5q NTRK3 discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models 2.2Å AUTH P.ALBAUGH,Y.FAN,Y.MI,F.SUN,F ADRIAN,N.LI,Y.YIA,Y.SARKISOVA,AUTH 2 A.KREUSCH,T.HOOD,M.LU,G.LIU,S.HUANG,Z.LIU,J.LOREN,AUTH 3 T.TUNTLAND,D.S.KARANEWSKY,H.M.SEIDEL,V.MOLTENITITL DISCOVERY OF GNF-5837, A SELECTIVE TRK INHIBITOR WITHTITL 2 EFFICACY IN RODENT CANCER TUMOR MODELSREF ACS MED.CHEM.LETT. 2012REFN ISSN 1948-5875DOI 10.1021/ML200261D Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3bq7 DGKD sam domain of diacylglycerol kinase delta1 (e35g) 2.9Å AUTH B.T.HARADA,M.J.KNIGHT,S.IMAI,F.QIAO,R.RAMACHANDER,AUTH 2 M.R.SAWAYA,M.GINGERY,F.SAKANE,J.U.BOWIETITL REGULATION OF ENZYME LOCALIZATION BYTITL 2 POLYMERIZATION: POLYMER FORMATION BY THE SAMTITL 3 DOMAIN OF DIACYLGLYCEROL KINASE DELTA1REF STRUCTURE V. 16 380 2008REFN ISSN 0969-2126PMID 18334213DOI 10.1016/J.STR.2007.12.017 Variant Set Distributions Mapped Variants
General Structure Information 1r79 DGKD solution structure of the c1 domain of the human diacylglycerol kinase delta -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C1 DOMAIN OF THE HUMANTITL 2 DIACYLGLYCEROL KINASE DELTAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3she MAPKAPK3 novel atp-competitive mk2 inhibitors with potent biochemical and cell- based activity throughout the series 2.25Å AUTH A.OUBRIE,A.KAPTEIN,E.DE ZWART,N.HOOGENBOOM,R.GOORDEN,AUTH 2 B.VAN DE KAR,M.VAN HOEK,V.DE KIMPE,R.VAN DER HEIJDEN,AUTH 3 J.BORSBOOM,B.KAZEMIER,J.DE ROOS,M.SCHEFFERS,J.LOMMERSE,AUTH 4 C.SCHULTZ-FADEMRECHT,T.BARFTITL NOVEL ATP COMPETITIVE MK2 INHIBITORS WITH POTENT BIOCHEMICALTITL 2 AND CELL-BASED ACTIVITY THROUGHOUT THE SERIES.REF BIOORG.MED.CHEM.LETT. V. 22 613 […]
General Structure Information 1wwc NTRK3 nt3 binding domain of human trkc receptor 1.9Å AUTH M.H.ULTSCH,C.WIESMANN,L.C.SIMMONS,J.HENRICH,M.YANG,D.REILLY,AUTH 2 S.H.BASS,A.M.DE VOSTITL CRYSTAL STRUCTURES OF THE NEUROTROPHIN-BINDING DOMAIN OFTITL 2 TRKA, TRKB AND TRKC.REF J.MOL.BIOL. V. 290 149 1999REFN ISSN 0022-2836PMID 10388563DOI 10.1006/JMBI.1999.2816 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2odt ITPK1 structure of human inositol 1,3,4-trisphosphate 5/6-kinase 2.01Å AUTH R.D.BUSAM,C.ARROWSMITH,H.BERGLUND,R.COLLINS,AUTH 2 A.EDWARDS,U.B.ERICSSON,S.FLODIN,A.FLORES,AUTH 3 M.HAMMARSTROM,S.L.HOLMBERG,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 D.OGG,J.SAGEMARK,M.SUNDSTROM,J.UPPENBERG,AUTH 6 S.VAN DEN BERG,J.WEIGELT,C.PERSSON,A.G.THORSELL,AUTH 7 B.M.HALLBERGTITL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATETITL 2 5/6-KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3twj ROCK1 rho-associated protein kinase 1 (rock 1) in complex with rki1447 2.9Å AUTH R.A.PATEL,K.D.FORINASH,R.PIREDDU,Y.SUN,N.SUN,M.P.MARTIN,AUTH 2 E.SCHONBRUNN,N.J.LAWRENCE,S.M.SEBTITITL RKI-1447 IS A POTENT INHIBITOR OF THE RHO-ASSOCIATED ROCKTITL 2 KINASES WITH ANTI-INVASIVE AND ANTITUMOR ACTIVITIES INTITL 3 BREAST CANCER.REF CANCER RES. V. 72 5025 2012REFN ISSN 0008-5472PMID 22846914DOI 10.1158/0008-5472.CAN-12-0954 Variant Set Distributions Ripley’s K […]
General Structure Information 3gc9 MAPK11 the structure of p38beta c119s, c162s in complex with a dihydroquinazolinone inhibitor 2.05Å AUTH S.B.PATEL,P.M.CAMERON,S.J.OKEEFE,B.FRANTZ-WATTLEY,AUTH 2 J.THOMPSON,E.A.ONEILL,T.TENNIS,L.LIU,J.W.BECKER,G.SCAPINTITL THE THREE-DIMENSIONAL STRUCTURE OF MAP KINASE P38BETA:TITL 2 DIFFERENT FEATURES OF THE ATP-BINDING SITE IN P38BETATITL 3 COMPARED WITH P38ALPHA.REF ACTA CRYSTALLOGR.,SECT.D V. 65 777 2009REFN ISSN 0907-4449PMID 19622861DOI 10.1107/S090744490901600X Variant Set Distributions […]
General Structure Information 3g2f BMPR2 crystal structure of the kinase domain of bone morphogenetic protein receptor type ii (bmpr2) at 2.35 a resolution 2.35Å TITL CRYSTAL STRUCTURE OF THE BMPR2 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants