General Structure Information
| PDB ID | 3v5q |
| HGNC Gene Label(s) | NTRK3 |
| Structure Name | discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models |
| Resolution | 2.2Å |
| Reference | AUTH P.ALBAUGH,Y.FAN,Y.MI,F.SUN,F ADRIAN,N.LI,Y.YIA,Y.SARKISOVA,AUTH 2 A.KREUSCH,T.HOOD,M.LU,G.LIU,S.HUANG,Z.LIU,J.LOREN,AUTH 3 T.TUNTLAND,D.S.KARANEWSKY,H.M.SEIDEL,V.MOLTENITITL DISCOVERY OF GNF-5837, A SELECTIVE TRK INHIBITOR WITHTITL 2 EFFICACY IN RODENT CANCER TUMOR MODELSREF ACS MED.CHEM.LETT. 2012REFN ISSN 1948-5875DOI 10.1021/ML200261D |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 262 |
| Number Of SNVs | 48 |
| Number Of Permutations | 6847 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.251 |
| p-value | 0.559 |
COSMIC
| Number Of Residues | 262 |
| Number Of SNVs | 13 |
| Number Of Permutations | 3591 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.038 |
| p-value | 0.866 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 48 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.03 |
| p-value | 0.304 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
