Assessment of Structural Intolerance and Durability
General Structure Information 1h0z SPINK5 lekti domain six -1.0Å AUTH T.LAUBER,A.SCHULZ,K.SCHWEIMER,K.ADERMANN,U.C.MARXTITL HOMOLOGOUS PROTEINS WITH DIFFERENT FOLDS: THETITL 2 THREE-DIMENSIONAL STRUCTURES OF DOMAINS 1 AND 6 OFTITL 3 THE MULTIPLE KAZAL-TYPE INHIBITOR LEKTIREF J.MOL.BIOL. V. 328 205 2003REFN ISSN 0022-2836PMID 12684009DOI 10.1016/S0022-2836(03)00245-6 Variant Set Distributions Mapped Variants
General Structure Information 2wvr CDT1 human cdt1:geminin complex 3.3Å AUTH V.DE MARCO,P.J.GILLESPIE,A.LI,N.KARANTZELIS,AUTH 2 E.CHRISTODOULOU,R.KLOMPMAKER,S.VAN GERWEN,A.FISH,AUTH 3 M.V.PETOUKHOV,M.S.ILIOU,Z.LYGEROU,R.H.MEDEMA,AUTH 4 J.J.BLOW,D.I.SVERGUN,S.TARAVIRAS,A.PERRAKISTITL QUATERNARY STRUCTURE OF THE HUMAN CDT1-GEMININTITL 2 COMPLEX REGULATES DNA REPLICATION LICENSING.REF PROC.NATL.ACAD.SCI.USA V. 106 19807 2009REFN ISSN 0027-8424PMID 19906994DOI 10.1073/PNAS.0905281106 Variant Set Distributions Mapped Variants
General Structure Information 4ie5 FTO crystal structure of the human fat mass and obesity associated protein (fto) in complex with n-[(3-hydroxypyridin-2-yl)carbonyl]glycine (md6) 1.95Å AUTH W.S.AIK,M.DEMETRIADES,M.K.K.HAMDAN,E.A.L.BAGG,K.K.YEOH,AUTH 2 C.LEJEUNE,Z.ZHANG,M.A.MCDONOUGH,C.J.SCHOFIELDTITL STRUCTURAL BASIS FOR INHIBITION OF THE FAT MASS AND OBESITYTITL 2 ASSOCIATED PROTEIN (FTO)REF J.MED.CHEM. V. 56 3680 2013REFN ISSN 0022-2623PMID 23547775DOI 10.1021/JM400193D Variant Set Distributions Mapped Variants
General Structure Information 4h4f CTRC crystal structure of human chymotrypsin c (ctrc) bound to inhibitor eglin c from hirudo medicinalis 1.9Å AUTH J.BATRA,A.SZABO,T.R.CAULFIELD,A.S.SOARES,M.SAHIN-TOTH,AUTH 2 E.S.RADISKYTITL LONG-RANGE ELECTROSTATIC COMPLEMENTARITY GOVERNS SUBSTRATETITL 2 RECOGNITION BY HUMAN CHYMOTRYPSIN C, A KEY REGULATOR OFTITL 3 DIGESTIVE ENZYME ACTIVATION.REF J.BIOL.CHEM. V. 288 9848 2013REFN ISSN 0021-9258PMID 23430245DOI 10.1074/JBC.M113.457382 Variant Set […]
General Structure Information 3f5n SERPINI1 structure of native human neuroserpin 3.15Å AUTH S.RICAGNO,S.CACCIA,G.SORRENTINO,G.ANTONINI,M.BOLOGNESITITL HUMAN NEUROSERPIN: STRUCTURE AND TIME-DEPENDENT INHIBITIONREF J.MOL.BIOL. V. 388 109 2009REFN ISSN 0022-2836PMID 19265707DOI 10.1016/J.JMB.2009.02.056 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v6a API5 helical repeat structure of apoptosis inhibitor 5 reveals protein- protein interaction modules 2.6Å AUTH B.G.HAN,K.H.KIM,S.J.LEE,K.C.JEONG,J.W.CHO,K.H.NOH,T.W.KIM,AUTH 2 S.J.KIM,H.J.YOON,S.W.SUH,S.H.LEE,B.I.LEETITL HELICAL REPEAT STRUCTURE OF APOPTOSIS INHIBITOR 5 REVEALSTITL 2 PROTEIN-PROTEIN INTERACTION MODULES.REF J.BIOL.CHEM. V. 287 10727 2012REFN ISSN 0021-9258PMID 22334682DOI 10.1074/JBC.M111.317594 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1r55 ADAM33 crystal structure of the catalytic domain of human adam 33 1.58Å AUTH P.ORTH,P.REICHERT,W.WANG,W.W.PROSISE,T.YAROSH-TOMAINE,AUTH 2 G.HAMMOND,L.XIAO,U.A.MIRZA,J.ZOU,C.STRICKLAND,S.S.TAREMI,AUTH 3 H.V.LE,V.MADISONTITL CRYSTAL STRUCTRE OF THE CATALYTIC DOMAIN OF HUMAN ADAM33REF J.MOL.BIOL. V. 335 129 2004REFN ISSN 0022-2836PMID 14659745DOI 10.1016/J.JMB.2003.10.037 Variant Set Distributions Mapped Variants
General Structure Information 4jt6 MLST8 structure of mtordeltan-mlst8-pi-103 complex 3.6Å AUTH H.YANG,D.G.RUDGE,J.D.KOOS,B.VAIDIALINGAM,H.J.YANG,AUTH 2 N.P.PAVLETICHTITL MTOR KINASE STRUCTURE, MECHANISM AND REGULATION.REF NATURE V. 497 217 2013REFN ISSN 0028-0836PMID 23636326DOI 10.1038/NATURE12122 Variant Set Distributions Mapped Variants
General Structure Information 4jxh CYTH2 complexe of arno sec7 domain with the protein-protein interaction inhibitor n-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at ph 8.5 1.47Å AUTH J.ROUHANA,F.HOH,S.ESTARAN,C.HENRIQUET,Y.BOUBLIK,A.KERKOUR,AUTH 2 R.TROUILLARD,J.MARTINEZ,M.PUGNIERE,A.PADILLA,A.CHAVANIEUTITL FRAGMENT-BASED IDENTIFICATION OF A LOCUS IN THE SEC7 DOMAINTITL 2 OF ARNO FOR THE DESIGN OF PROTEIN-PROTEIN INTERACTIONTITL 3 INHIBITORSREF J.MED.CHEM. V. 56 8497 2013REFN ISSN 0022-2623PMID 24112024DOI 10.1021/JM4009357 Variant Set […]
General Structure Information 2bo9 LXN human carboxypeptidase a4 in complex with human latexin. 1.6Å AUTH I.PALLARES,R.BONET,R.GARCIA-CASTELLANOS,S.VENTURA,AUTH 2 F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUETHTITL STRUCTURE OF HUMAN CARBOXYPEPTIDASE A4 WITH ITSTITL 2 ENDOGENOUS PROTEIN INHIBITOR, LATEXIN.REF PROC.NATL.ACAD.SCI.USA V. 102 3978 2005REFN ISSN 0027-8424PMID 15738388DOI 10.1073/PNAS.0500678102 Variant Set Distributions Mapped Variants