3FZM.B | BAG1

General Structure Information 3fzm BAG1 crystal structures of hsc70/bag1 in complex with small molecule inhibitors 2.3Å AUTH D.S.WILLIAMSON,J.BORGOGNONI,A.CLAY,Z.DANIELS,AUTH 2 P.DOKURNO,M.J.DRYSDALE,N.FOLOPPE,G.L.FRANCIS,AUTH 3 C.J.GRAHAM,R.HOWES,A.T.MACIAS,J.B.MURRAY,R.PARSONS,AUTH 4 T.SHAW,A.E.SURGENOR,L.TERRY,Y.WANG,M.WOOD,AUTH 5 A.J.MASSEYTITL NOVEL ADENOSINE-DERIVED INHIBITORS OF 70 KDA HEATTITL 2 SHOCK PROTEIN, DISCOVERED THROUGH STRUCTURE-BASEDTITL 3 DESIGNREF J.MED.CHEM. V. 52 1510 2009REFN ISSN 0022-2623PMID 19256508DOI 10.1021/JM801627A Variant Set Distributions Ripley’s K […]

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2ZV2.A | CAMKK2

General Structure Information 2zv2 CAMKK2 crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, camkk2 kinase domain in complex with sto-609 2.4Å AUTH M.KUKIMOTO-NIINO,S.YOSHIKAWA,T.TAKAGI,N.OHSAWA,Y.TOMABECHI,AUTH 2 T.TERADA,M.SHIROUZU,A.SUZUKI,S.LEE,T.YAMAUCHI,M.OKADA-IWABU,AUTH 3 M.IWABU,T.KADOWAKI,Y.MINOKOSHI,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE CA2+/CALMODULIN-DEPENDENT PROTEINTITL 2 KINASE KINASE IN COMPLEX WITH THE INHIBITOR STO-609REF J.BIOL.CHEM. V. 286 22570 2011REFN ISSN 0021-9258PMID 21504895DOI 10.1074/JBC.M111.251710 Variant Set […]

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2VT8.B | PSMF1

General Structure Information 2vt8 PSMF1 structure of a conserved dimerisation domain within fbox7 and pi31 2.6Å AUTH R.J.KIRK,H.LAMAN,P.P.KNOWLES,J.MURRAY-RUST,AUTH 2 M.LOMONOSOV,E.K.MEZIANE,N.Q.MCDONALDTITL STRUCTURE OF A CONSERVED DIMERIZATION DOMAINTITL 2 WITHIN THE F-BOX PROTEIN FBXO7 AND THE PI31TITL 3 PROTEASOME INHIBITOR.REF J.BIOL.CHEM. V. 283 22325 2008REFN ISSN 0021-9258PMID 18495667DOI 10.1074/JBC.M709900200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]

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4F52.F | GLMN

General Structure Information 4f52 GLMN structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants

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2VN8.A | RTN4IP1

General Structure Information 2vn8 RTN4IP1 crystal structure of human reticulon 4 interacting protein 1 in complex with nadph 2.1Å AUTH A.C.W.PIKE,K.GUO,J.ELKINS,E.UGOCHUKWU,A.K.ROOS,AUTH 2 P.FILIPPAKOPOULOS,F.VON DELFT,A.EDWARDS,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEINTITL 2 1 IN COMPLEX WITH NADPHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]

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4LY1.C | HDAC2

General Structure Information 4ly1 HDAC2 structure of human hdac2 in complex with inhibitor 4-(acetylamino)-n- [2-amino-5-(thiophen-2-yl)phenyl]benzamide 1.57Å AUTH B.E.LAUFFER,R.MINTZER,R.FONG,S.MUKUND,C.TAM,I.ZILBERLEYB,AUTH 2 B.FLICKE,A.RITSCHER,G.FEDOROWICZ,R.VALLERO,D.F.ORTWINE,AUTH 3 J.GUNZNER,Z.MODRUSAN,L.NEUMANN,C.M.KOTH,P.J.LUPARDUS,AUTH 4 J.S.KAMINKER,C.E.HEISE,P.STEINERTITL HISTONE DEACETYLASE (HDAC) INHIBITOR KINETIC RATE CONSTANTSTITL 2 CORRELATE WITH CELLULAR HISTONE ACETYLATION BUT NOTTITL 3 TRANSCRIPTION AND CELL VIABILITY.REF J.BIOL.CHEM. V. 288 26926 2013REFN ISSN 0021-9258PMID 23897821DOI 10.1074/JBC.M113.490706 Variant Set […]

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3RJW.A | EHMT2

General Structure Information 3rjw EHMT2 crystal structure of histone lysine methyltransferase g9a with an inhibitor 2.56Å AUTH M.VEDADI,D.BARSYTE-LOVEJOY,F.LIU,S.RIVAL-GERVIER,AUTH 2 A.ALLALI-HASSANI,V.LABRIE,T.J.WIGLE,P.A.DIMAGGIO,G.A.WASNEY,AUTH 3 A.SIARHEYEVA,A.DONG,W.TEMPEL,S.C.WANG,X.CHEN,I.CHAU,AUTH 4 T.J.MANGANO,X.P.HUANG,C.D.SIMPSON,S.G.PATTENDEN,J.L.NORRIS,AUTH 5 D.B.KIREEV,A.TRIPATHY,A.EDWARDS,B.L.ROTH,W.P.JANZEN,AUTH 6 B.A.GARCIA,A.PETRONIS,J.ELLIS,P.J.BROWN,S.V.FRYE,AUTH 7 C.H.ARROWSMITH,J.JINTITL A CHEMICAL PROBE SELECTIVELY INHIBITS G9A AND GLPTITL 2 METHYLTRANSFERASE ACTIVITY IN CELLS.REF NAT.CHEM.BIOL. V. 7 566 2011REFN ISSN 1552-4450PMID 21743462DOI 10.1038/NCHEMBIO.599 Variant Set Distributions […]

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2IZV.A | SOCS4

General Structure Information 2izv SOCS4 crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution 2.55Å AUTH A.N.BULLOCK,M.C.RODRIGUEZ,J.E.DEBRECZENI,Z.SONGYANG,S.KNAPPTITL STRUCTURE OF THE SOCS4-ELONGINB/C COMPLEX REVEALS ATITL 2 DISTINCT SOCS BOX INTERFACE AND THE MOLECULAR BASIS FORTITL 3 SOCS-DEPENDENT EGFR DEGRADATION.REF STRUCTURE V. 15 1493 2007REFN ISSN 0969-2126PMID 17997974DOI 10.1016/J.STR.2007.09.016 Variant Set Distributions Mapped […]

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4F0D.A | PARP16

General Structure Information 4f0d PARP16 human artd15/parp16 in complex with 3-aminobenzamide 2.7Å AUTH T.KARLBERG,A.G.THORSELL,A.KALLAS,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSE TRANSFERASETITL 2 ARTD15/PARP16 REVEALS A NOVEL PUTATIVE REGULATORY DOMAIN.REF J.BIOL.CHEM. V. 287 24077 2012REFN ISSN 0021-9258PMID 22661712DOI 10.1074/JBC.M112.379289 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4I7C.C | SIAH1

General Structure Information 4i7c SIAH1 siah1 mutant bound to synthetic peptide (ace)klrpv(23p)mvrpwvr 2.8Å AUTH J.L.STEBBINS,E.SANTELLI,Y.FENG,S.K.DE,A.PURVES,AUTH 2 K.MOTAMEDCHABOKI,B.WU,Z.A.RONAI,R.C.LIDDINGTON,M.PELLECCHIATITL STRUCTURE-BASED DESIGN OF COVALENT SIAH INHIBITORS.REF CHEM.BIOL. V. 20 973 2013REFN ISSN 1074-5521PMID 23891150DOI 10.1016/J.CHEMBIOL.2013.06.008 Variant Set Distributions Mapped Variants

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