General Structure Information
| PDB ID | 3fzm |
| HGNC Gene Label(s) | BAG1 |
| Structure Name | crystal structures of hsc70/bag1 in complex with small molecule inhibitors |
| Resolution | 2.3Å |
| Reference | AUTH D.S.WILLIAMSON,J.BORGOGNONI,A.CLAY,Z.DANIELS,AUTH 2 P.DOKURNO,M.J.DRYSDALE,N.FOLOPPE,G.L.FRANCIS,AUTH 3 C.J.GRAHAM,R.HOWES,A.T.MACIAS,J.B.MURRAY,R.PARSONS,AUTH 4 T.SHAW,A.E.SURGENOR,L.TERRY,Y.WANG,M.WOOD,AUTH 5 A.J.MASSEYTITL NOVEL ADENOSINE-DERIVED INHIBITORS OF 70 KDA HEATTITL 2 SHOCK PROTEIN, DISCOVERED THROUGH STRUCTURE-BASEDTITL 3 DESIGNREF J.MED.CHEM. V. 52 1510 2009REFN ISSN 0022-2623PMID 19256508DOI 10.1021/JM801627A |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 110 |
| Number Of SNVs | 33 |
| Number Of Permutations | 19124 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.093 |
| p-value | 0.023 |
COSMIC
| Number Of Residues | 110 |
| Number Of SNVs | 3 |
| Number Of Permutations | 103 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.667 |
| p-value | 0.755 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 33 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.278 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
