General Structure Information
| PDB ID | 4ly1 |
| HGNC Gene Label(s) | HDAC2 |
| Structure Name | structure of human hdac2 in complex with inhibitor 4-(acetylamino)-n- [2-amino-5-(thiophen-2-yl)phenyl]benzamide |
| Resolution | 1.57Å |
| Reference | AUTH B.E.LAUFFER,R.MINTZER,R.FONG,S.MUKUND,C.TAM,I.ZILBERLEYB,AUTH 2 B.FLICKE,A.RITSCHER,G.FEDOROWICZ,R.VALLERO,D.F.ORTWINE,AUTH 3 J.GUNZNER,Z.MODRUSAN,L.NEUMANN,C.M.KOTH,P.J.LUPARDUS,AUTH 4 J.S.KAMINKER,C.E.HEISE,P.STEINERTITL HISTONE DEACETYLASE (HDAC) INHIBITOR KINETIC RATE CONSTANTSTITL 2 CORRELATE WITH CELLULAR HISTONE ACETYLATION BUT NOTTITL 3 TRANSCRIPTION AND CELL VIABILITY.REF J.BIOL.CHEM. V. 288 26926 2013REFN ISSN 0021-9258PMID 23897821DOI 10.1074/JBC.M113.490706 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 366 |
| Number Of SNVs | 15 |
| Number Of Permutations | 1837 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.029 |
| p-value | 0.253 |
COSMIC
| Number Of Residues | 366 |
| Number Of SNVs | 6 |
| Number Of Permutations | 459 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.067 |
| p-value | 0.923 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 15 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.105 |
| p-value | 0.726 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
