Assessment of Structural Intolerance and Durability
General Structure Information 3it8 TNF crystal structure of tnf alpha complexed with a poxvirus mhc-related tnf binding protein 2.8Å AUTH Z.YANG,A.P.WEST JR.,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF TNFA COMPLEXED WITH A POXVIRUSTITL 2 MHC-RELATED TNF BINDING PROTEINREF NAT.STRUCT.MOL.BIOL.REFN ESSN 1545-9985DOI 10.1038/NSMB.1683 Variant Set Distributions Mapped Variants
General Structure Information 2xwb C3 crystal structure of complement c3b in complex with factors b and d 3.49Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2xwb CFB crystal structure of complement c3b in complex with factors b and d 3.49Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3qkg AMBP crystal structure of alpha-1-microglobulin at 2.3 a resolution 2.3Å AUTH W.MEINING,A.SKERRATITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA(1)-MICROGLOBULINTITL 2 REVEALS A POTENTIAL HAEM-BINDING SITE.REF BIOCHEM.J. V. 445 175 2012REFN ISSN 0264-6021PMID 22512701DOI 10.1042/BJ20120448 Variant Set Distributions Mapped Variants
General Structure Information 1au1 IFNB1 human interferon-beta crystal structure 2.2Å AUTH M.KARPUSAS,M.NOLTE,C.B.BENTON,W.MEIER,W.N.LIPSCOMB,AUTH 2 S.GOELZTITL THE CRYSTAL STRUCTURE OF HUMAN INTERFERON BETA ATTITL 2 2.2-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 94 11813 1997REFN ISSN 0027-8424PMID 9342320DOI 10.1073/PNAS.94.22.11813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rbg CRTAM crystal structure analysis of class-i mhc restricted t-cell associated molecule 2.3Å AUTH R.RUBINSTEIN,U.A.RAMAGOPAL,S.G.NATHENSON,S.C.ALMO,A.FISERTITL FUNCTIONAL CLASSIFICATION OF IMMUNE REGULATORY PROTEINS.REF STRUCTURE V. 21 766 2013REFN ISSN 0969-2126PMID 23583034DOI 10.1016/J.STR.2013.02.022 Variant Set Distributions Mapped Variants
General Structure Information 3kls C5 structure of complement c5 in complex with ssl7 3.6Å AUTH N.S.LAURSEN,N.GORDON,S.HERMANS,N.LORENZ,N.JACKSON,B.WINES,AUTH 2 E.SPILLNER,J.B.CHRISTENSEN,M.JENSEN,F.FREDSLUND,M.BJERRE,AUTH 3 L.SOTTRUP-JENSEN,J.D.FRASER,G.R.ANDERSENTITL STRUCTURAL BASIS FOR INHIBITION OF COMPLEMENT C5 BY THE SSL7TITL 2 PROTEIN FROM STAPHYLOCOCCUS AUREUSREF PROC.NATL.ACAD.SCI.USA V. 107 3681 2010REFN ISSN 0027-8424PMID 20133685DOI 10.1073/PNAS.0910565107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2oay SERPING1 crystal structure of latent human c1-inhibitor 2.35Å AUTH L.BEINROHR,V.HARMAT,J.DOBO,Z.LORINCZ,P.GAL,P.ZAVODSZKYTITL C1 INHIBITOR SERPIN DOMAIN STRUCTURE REVEALS THE LIKELYTITL 2 MECHANISM OF HEPARIN POTENTIATION AND CONFORMATIONAL DISEASEREF J.BIOL.CHEM. V. 282 21100 2007REFN ISSN 0021-9258PMID 17488724DOI 10.1074/JBC.M700841200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2a55 C4BPA solution structure of the two n-terminal ccp modules of c4b- binding protein (c4bp) alpha-chain. -1.0Å AUTH H.T.JENKINS,L.MARK,G.BALL,J.PERSSON,G.LINDAHL,AUTH 2 D.UHRIN,A.M.BLOM,P.N.BARLOWTITL HUMAN C4B-BINDING PROTEIN, STRUCTURAL BASIS FORTITL 2 INTERACTION WITH STREPTOCOCCAL M PROTEIN, A MAJORTITL 3 BACTERIAL VIRULENCE FACTORREF J.BIOL.CHEM. V. 281 3690 2006REFN ISSN 0021-9258PMID 16330538DOI 10.1074/JBC.M511563200 Variant Set Distributions Mapped […]
General Structure Information 2wnu C1QA complex between c1q globular heads and heparan sulfate 2.3Å AUTH V.GARLATTI,A.CHOUQUET,T.LUNARDI,R.VIVES,H.PAIDASSI,AUTH 2 H.LORTAT-JACOB,N.M.THIELENS,G.J.ARLAUD,C.GABORIAUDTITL CUTTING EDGE: C1Q BINDS DEOXYRIBOSE AND HEPARANTITL 2 SULFATE THROUGH NEIGHBORING SITES OF ITSTITL 3 RECOGNITION DOMAIN.REF J.IMMUNOL. V. 185 808 2010REFN ISSN 0022-1767PMID 20548024DOI 10.4049/JIMMUNOL.1000184 Variant Set Distributions Mapped Variants