Assessment of Structural Intolerance and Durability
General Structure Information 1nl0 F9 crystal structure of human factor ix gla domain in complex of an inhibitory antibody, 10c12 2.2Å AUTH M.HUANG,B.C.FURIE,B.FURIETITL CRYSTAL STRUCTURE OF THE CALCIUM-STABILIZED HUMANTITL 2 FACTOR IX GLA DOMAIN BOUND TO ATITL 3 CONFORMATION-SPECIFIC ANTI-FACTOR IX ANTIBODY.REF J.BIOL.CHEM. V. 279 14338 2004REFN ISSN 0021-9258PMID 14722079DOI 10.1074/JBC.M314011200 Variant Set Distributions Mapped […]
General Structure Information 3b2d LY86 crystal structure of human rp105/md-1 complex 2.8Å AUTH U.OHTO,K.MIYAKE,T.SHIMIZUTITL CRYSTAL STRUCTURES OF MOUSE AND HUMAN RP105/MD-1 COMPLEXESTITL 2 REVEAL UNIQUE DIMER ORGANIZATION OF THE TOLL-LIKE RECEPTORTITL 3 FAMILY.REF J.MOL.BIOL. V. 413 815 2011REFN ISSN 0022-2836PMID 21959264DOI 10.1016/J.JMB.2011.09.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ott CD5 crystal structure of cd5_diii 2.5Å AUTH B.RODAMILANS,I.G.MUNOZ,E.BRAGADO-NILSSON,M.R.SARRIAS,AUTH 2 O.PADILLA,F.J.BLANCO,F.LOZANO,G.MONTOYATITL CRYSTAL STRUCTURE OF THE THIRD EXTRACELLULAR DOMAIN OF CD5TITL 2 REVEALS THE FOLD OF A GROUP B SCAVENGER CYSTEINE-RICHTITL 3 RECEPTOR DOMAIN.REF J.BIOL.CHEM. V. 282 12669 2007REFN ISSN 0021-9258PMID 17322294DOI 10.1074/JBC.M611699200 Variant Set Distributions Mapped Variants
General Structure Information 2wnv C1QC complex between c1q globular heads and deoxyribose 1.25Å AUTH V.GARLATTI,A.CHOUQUET,T.LUNARDI,R.VIVES,H.PAIDASSI,AUTH 2 H.LORTAT-JACOB,N.M.THIELENS,G.J.ARLAUD,C.GABORIAUDTITL CUTTING EDGE: C1Q BINDS DEOXYRIBOSE AND HEPARANTITL 2 SULFATE THROUGH NEIGHBORING SITES OF ITSTITL 3 RECOGNITION DOMAIN.REF J.IMMUNOL. V. 185 808 2010REFN ISSN 0022-1767PMID 20548024DOI 10.4049/JIMMUNOL.1000184 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2jp0 CD5 solution structure of the n-terminal extraceullular domain of the lymphocyte receptor cd5 calculated using inferential structure determination (isd) -1.0Å AUTH A.GARZA-GARCIA,D.ESPOSITO,W.RIEPING,R.HARRIS,AUTH 2 C.BRIGGS,M.H.BROWN,P.C.DRISCOLLTITL THREE-DIMENSIONAL SOLUTION STRUCTURE ANDTITL 2 CONFORMATIONAL PLASTICITY OF THE N-TERMINALTITL 3 SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN OF HUMANTITL 4 CD5REF J.MOL.BIOL. V. 378 129 2008REFN ISSN 0022-2836PMID 18339402DOI […]
General Structure Information 4hw5 C3 crystal structure of the human c3a anaphylatoxin 2.25Å AUTH G.BAJIC,L.YATIME,A.KLOS,G.R.ANDERSENTITL HUMAN C3A AND C3A DESARG ANAPHYLATOXINS HAVE CONSERVEDTITL 2 STRUCTURES, IN CONTRAST TO C5A AND C5A DESARG.REF PROTEIN SCI. V. 22 204 2013REFN ISSN 0961-8368PMID 23184394DOI 10.1002/PRO.2200 Variant Set Distributions Mapped Variants
General Structure Information 2xrc CFI human complement factor i 2.69Å AUTH P.ROVERSI,S.JOHNSON,J.J.CAESAR,F.MCLEAN,K.J.LEATH,AUTH 2 S.A.TSIFTSOGLOU,B.P.MORGAN,C.L.HARRIS,R.B.SIM,S.M.LEATITL STRUCTURAL BASIS FOR COMPLEMENT FACTOR I CONTROL AND ITSTITL 2 DISEASE-ASSOCIATED SEQUENCE POLYMORPHISMS.REF PROC.NATL.ACAD.SCI.USA V. 108 12839 2011REFN ISSN 0027-8424PMID 21768352DOI 10.1073/PNAS.1102167108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jg8 C1QB crystallographic structure of human c1q globular heads complexed to phosphatidyl-serine 2.05Å AUTH H.PAIDASSI,P.TACNET-DELORME,V.GARLATTI,C.DARNAULT,AUTH 2 B.GHEBREHIWET,C.GABORIAUD,G.J.ARLAUD,P.FRACHETTITL C1Q BINDS PHOSPHATIDYLSERINE AND LIKELY ACTS AS ATITL 2 MULTILIGAND-BRIDGING MOLECULE IN APOPTOTIC CELLTITL 3 RECOGNITION.REF J.IMMUNOL. V. 180 2329 2008REFN ISSN 0022-1767PMID 18250442 Variant Set Distributions Mapped Variants
General Structure Information 1onq CD1A crystal structure of cd1a in complex with a sulfatide 2.15Å AUTH D.M.ZAJONC,M.A.ELSLIGER,L.TEYTON,I.A.WILSONTITL CRYSTAL STRUCTURE OF CD1A IN COMPLEX WITH A SULFATIDE SELFTITL 2 ANTIGEN AT A RESOLUTION OF 2.15 A.REF NAT.IMMUNOL. V. 4 808 2003REFN ISSN 1529-2908PMID 12833155DOI 10.1038/NI948 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3bt1 PLAU structure of urokinase receptor, urokinase and vitronectin complex 2.8Å AUTH Q.HUAI,A.ZHOU,L.LIN,A.P.MAZAR,G.C.PARRY,J.CALLAHAN,D.E.SHAW,AUTH 2 B.FURIE,B.C.FURIE,M.HUANGTITL CRYSTAL STRUCTURES OF TWO HUMAN VITRONECTIN, UROKINASE ANDTITL 2 UROKINASE RECEPTOR COMPLEXESREF NAT.STRUCT.MOL.BIOL. V. 15 422 2008REFN ISSN 1545-9993PMID 18376415DOI 10.1038/NSMB.1404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants