Assessment of Structural Intolerance and Durability
General Structure Information 2xwj C3 crystal structure of complement c3b in complex with factor b 4.0Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4kc3 IL33 cytokine/receptor binary complex 3.27Å AUTH X.LIU,M.HAMMEL,Y.HE,J.A.TAINER,U.S.JENG,L.ZHANG,S.WANG,AUTH 2 X.WANGTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF IL-33 WITH ITSTITL 2 RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 110 14918 2013REFN ISSN 0027-8424PMID 23980170DOI 10.1073/PNAS.1308651110 Variant Set Distributions Mapped Variants
General Structure Information 3s5l HLA-DRA crystal structure of cd4 mutant bound to hla-dr1 2.1Å AUTH X.X.WANG,Y.LI,Y.YIN,M.MO,Q.WANG,W.GAO,L.WANG,R.A.MARIUZZATITL AFFINITY MATURATION OF HUMAN CD4 BY YEAST SURFACE DISPLAYTITL 2 AND CRYSTAL STRUCTURE OF A CD4-HLA-DR1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 108 15960 2011REFN ISSN 0027-8424PMID 21900604DOI 10.1073/PNAS.1109438108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1e4j FCGR3B crystal structure of the soluble human fc-gamma receptor iii 2.5Å AUTH P.SONDERMANN,R.HUBER,V.OOSTHUIZEN,U.JACOBTITL THE 3.2-A CRYSTAL STRUCTURE OF THE HUMAN IGG1 FCTITL 2 FRAGMENT-FC GAMMARIII COMPLEX.REF NATURE V. 406 267 2000REFN ISSN 0028-0836PMID 10917521DOI 10.1038/35018508 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cpc OBSL1 solution structure of rsgi ruh-030, an ig like domain from human cdna -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.ONUKI,H.HIROTA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-030, AN IG LIKETITL 2 DOMAIN FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1yck PGLYRP1 crystal structure of human peptidoglycan recognition protein (pgrp-s) 1.7Å AUTH R.GUAN,Q.WANG,E.J.SUNDBERG,R.A.MARIUZZATITL CRYSTAL STRUCTURE OF HUMAN PEPTIDOGLYCANTITL 2 RECOGNITION PROTEIN S (PGRP-S) AT 1.70 ATITL 3 RESOLUTION.REF J.MOL.BIOL. V. 347 683 2005REFN ISSN 0022-2836PMID 15769462DOI 10.1016/J.JMB.2005.01.070 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z7x TLR2 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3mop IRAK2 the ternary death domain complex of myd88, irak4, and irak2 3.4Å AUTH S.C.LIN,Y.C.LO,H.WUTITL HELICAL ASSEMBLY IN THE MYD88-IRAK4-IRAK2 COMPLEX INTITL 2 TLR/IL-1R SIGNALLING.REF NATURE V. 465 885 2010REFN ISSN 0028-0836PMID 20485341DOI 10.1038/NATURE09121 Variant Set Distributions Mapped Variants
General Structure Information 3ulv TLR3 structure of quaternary complex of human tlr3ecd with three fabs (form2) 3.52Å AUTH J.LUO,G.OBMOLOVA,T.J.MALIA,S.J.WU,K.E.DUFFY,J.D.MARION,AUTH 2 J.K.BELL,P.GE,Z.H.ZHOU,A.TEPLYAKOV,Y.ZHAO,R.J.LAMB,AUTH 3 J.L.JORDAN,L.R.SAN MATEO,R.W.SWEET,G.L.GILLILANDTITL LATERAL CLUSTERING OF TLR3:DSRNA SIGNALING UNITS REVEALED BYTITL 2 TLR3ECD:3FABS QUATERNARY STRUCTURE.REF J.MOL.BIOL. V. 421 112 2012REFN ISSN 0022-2836PMID 22579623DOI 10.1016/J.JMB.2012.05.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4g8a TLR4 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]