Assessment of Structural Intolerance and Durability
General Structure Information 1kcg KLRK1 nkg2d in complex with ulbp3 2.6Å AUTH S.RADAEV,B.ROSTRO,A.G.BROOKS,M.COLONNA,P.D.SUNTITL CONFORMATIONAL PLASTICITY REVEALED BY THETITL 2 COCRYSTAL STRUCTURE OF NKG2D AND ITS CLASS ITITL 3 MHC-LIKE LIGAND ULBP3.REF IMMUNITY V. 15 1039 2001REFN ISSN 1074-7613PMID 11754823DOI 10.1016/S1074-7613(01)00241-2 Variant Set Distributions Mapped Variants
General Structure Information 1el0 CCL1 solution structure of the human cc chemokine, i-309 -1.0Å AUTH D.W.KEIZER,M.P.CRUMP,T.W.LEE,C.M.SLUPSKY,AUTH 2 I.CLARK-LEWIS,B.D.SYKESTITL HUMAN CC CHEMOKINE I-309, STRUCTURAL CONSEQUENCESTITL 2 OF THE ADDITIONAL DISULFIDE BOND.REF BIOCHEMISTRY V. 39 6053 2000REFN ISSN 0006-2960PMID 10821677DOI 10.1021/BI000089L Variant Set Distributions Mapped Variants
General Structure Information 1y6k IL10 crystal structure of human il-10 complexed with the soluble il-10r1 chain 2.52Å AUTH S.I.YOON,B.C.JONES,N.J.LOGSDON,M.R.WALTERTITL SAME STRUCTURE, DIFFERENT FUNCTION CRYSTALTITL 2 STRUCTURE OF THE EPSTEIN-BARR VIRUS IL-10 BOUND TOTITL 3 THE SOLUBLE IL-10R1 CHAIN.REF STRUCTURE V. 13 551 2005REFN ISSN 0969-2126PMID 15837194DOI 10.1016/J.STR.2005.01.016 Variant Set Distributions Mapped Variants
General Structure Information 3o4o IL1R2 crystal structure of an interleukin-1 receptor complex 3.3Å AUTH D.L.WANG,S.Y.ZHANG,L.LI,X.LIU,K.R.MEI,X.Q.WANGTITL STRUCTURAL INSIGHTS INTO THE ASSEMBLY AND ACTIVATION OFTITL 2 IL-1BETA WITH ITS RECEPTORSREF NAT.IMMUNOL. V. 11 905 2010REFN ISSN 1529-2908PMID 20802483DOI 10.1038/NI.1925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ovz FCAR crystal structure of human fcari 3.0Å AUTH A.B.HERR,E.R.BALLISTER,P.J.BJORKMANTITL INSIGHTS INTO IGA-MEDIATED IMMUNE RESPONSES FROM THE CRYSTALTITL 2 STRUCTURES OF HUMAN FC-ALPHA-RI AND ITS COMPLEX WITH IGA1-FCREF NATURE V. 423 614 2003REFN ISSN 0028-0836PMID 12768205DOI 10.1038/NATURE01685 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ov6 B2M cd1c in complex with mpm (mannosyl-beta1-phosphomycoketide) 2.5Å AUTH L.SCHARF,N.S.LI,A.J.HAWK,D.GARZON,T.ZHANG,L.M.FOX,A.R.KAZEN,AUTH 2 S.SHAH,E.J.HADDADIAN,J.E.GUMPERZ,A.SAGHATELIAN,AUTH 3 J.D.FARALDO-GOMEZ,S.C.MEREDITH,J.A.PICCIRILLI,E.J.ADAMSTITL THE 2.5 A STRUCTURE OF CD1C IN COMPLEX WITH A MYCOBACTERIALTITL 2 LIPID REVEALS AN OPEN GROOVE IDEALLY SUITED FOR DIVERSETITL 3 ANTIGEN PRESENTATIONREF IMMUNITY V. 33 853 2010REFN ISSN 1074-7613PMID 21167756DOI 10.1016/J.IMMUNI.2010.11.026 Variant Set Distributions Mapped […]
General Structure Information 4gbx HLA-DMB crystal structure of an immune complex at ph 6.5 3.0Å AUTH W.POS,D.K.SETHI,M.J.CALL,M.S.SCHULZE,A.K.ANDERS,J.PYRDOL,AUTH 2 K.W.WUCHERPFENNIGTITL CRYSTAL STRUCTURE OF THE HLA-DM-HLA-DR1 COMPLEX DEFINESTITL 2 MECHANISMS FOR RAPID PEPTIDE SELECTION.REF CELL(CAMBRIDGE,MASS.) V. 151 1557 2012REFN ISSN 0092-8674PMID 23260142DOI 10.1016/J.CELL.2012.11.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1g1q SELP crystal structure of p-selectin lectin/egf domains 2.4Å AUTH W.S.SOMERS,J.TANG,G.D.SHAW,R.T.CAMPHAUSENTITL INSIGHTS INTO THE MOLECULAR BASIS OF LEUKOCYTETITL 2 TETHERING AND ROLLING REVEALED BY STRUCTURES OF P-TITL 3 AND E-SELECTIN BOUND TO SLE(X) AND PSGL-1.REF CELL(CAMBRIDGE,MASS.) V. 103 467 2000REFN ISSN 0092-8674PMID 11081633DOI 10.1016/S0092-8674(00)00138-0 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4a5w C6 crystal structure of c5b6 3.5Å AUTH M.A.HADDERS,D.BUBECK,P.ROVERSI,S.HAKOBYAN,F.FORNERIS,AUTH 2 B.P.MORGAN,M.K.PANGBURN,O.LLORCA,S.M.LEA,P.GROSTITL ASSEMBLY AND REGULATION OF THE MEMBRANE ATTACK COMPLEXTITL 2 BASED ON STRUCTURES OF C5B6 AND SC5B9.REF CELL REP. V. 1 200 2012REFN ISSN 2211-1247PMID 22832194DOI 10.1016/J.CELREP.2012.02.003 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3g04 TSHR crystal structure of the tsh receptor in complex with a thyroid- stimulating autoantibody 2.55Å AUTH J.SANDERS,D.Y.CHIRGADZE,P.SANDERS,S.BAKER,A.SULLIVAN,AUTH 2 A.BHARDWAJA,J.BOLTON,M.REEVE,N.NAKATAKE,M.EVANS,T.RICHARDS,AUTH 3 M.POWELL,R.N.MIGUEL,T.L.BLUNDELL,J.FURMANIAK,B.R.SMITHTITL CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH ATITL 2 THYROID-STIMULATING AUTOANTIBODYREF THYROID V. 17 395 2007REFN ISSN 1050-7256PMID 17542669DOI 10.1089/THY.2007.0034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]