General Structure Information
| PDB ID | 3g04 |
| HGNC Gene Label(s) | TSHR |
| Structure Name | crystal structure of the tsh receptor in complex with a thyroid- stimulating autoantibody |
| Resolution | 2.55Å |
| Reference | AUTH J.SANDERS,D.Y.CHIRGADZE,P.SANDERS,S.BAKER,A.SULLIVAN,AUTH 2 A.BHARDWAJA,J.BOLTON,M.REEVE,N.NAKATAKE,M.EVANS,T.RICHARDS,AUTH 3 M.POWELL,R.N.MIGUEL,T.L.BLUNDELL,J.FURMANIAK,B.R.SMITHTITL CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH ATITL 2 THYROID-STIMULATING AUTOANTIBODYREF THYROID V. 17 395 2007REFN ISSN 1050-7256PMID 17542669DOI 10.1089/THY.2007.0034 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 228 |
| Number Of SNVs | 47 |
| Number Of Permutations | 21061 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.037 |
| p-value | 0.191 |
ClinVar
| Number Of Residues | 228 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1282 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.6 |
| p-value | 0.562 |
COSMIC
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 47 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.343 |
| p-value | 0.55 |
Cosmic vs. ExAC
