Assessment of Structural Intolerance and Durability
General Structure Information 3ibj PDE2A x-ray structure of pde2a 3.02Å AUTH J.PANDIT,M.D.FORMAN,K.F.FENNELL,K.S.DILLMAN,F.S.MENNITITITL MECHANISM FOR THE ALLOSTERIC REGULATION OF PHOSPHODIESTERASETITL 2 2A DEDUCED FROM THE X-RAY STRUCTURE OF A NEAR FULL-LENGTHTITL 3 CONSTRUCT.REF PROC.NATL.ACAD.SCI.USA V. 106 18225 2009REFN ISSN 0027-8424PMID 19828435DOI 10.1073/PNAS.0907635106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ee6 TPP1 crystal structure analysis of tripeptidyl peptidase -i 2.35Å AUTH A.PAL,R.KRAETZNER,T.GRUENE,M.GRAPP,K.SCHREIBER,M.GRONBORG,AUTH 2 H.URLAUB,S.BECKER,A.R.ASIF,J.GARTNER,G.M.SHELDRICK,AUTH 3 R.STEINFELDTITL STRUCTURE OF TRIPEPTIDYL-PEPTIDASE I PROVIDES INSIGHT INTOTITL 2 THE MOLECULAR BASIS OF LATE INFANTILE NEURONAL CEROIDTITL 3 LIPOFUSCINOSISREF J.BIOL.CHEM. V. 284 3976 2009REFN ISSN 0021-9258PMID 19038966DOI 10.1074/JBC.M806947200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2p0r CAPN9 structure of human calpain 9 in complex with leupeptin 2.5Å AUTH T.L.DAVIS,R.PARAMANATHAN,J.R.WALKER,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURES OF HUMAN MINICALPAINS BOUND TO INHIBITORSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2czh IMPA2 crystal structure of human myo-inositol monophosphatase 2 (impa2) with phosphate ion (orthorhombic form) 2.7Å AUTH R.ARAI,K.ITO,T.OHNISHI,H.OHBA,R.AKASAKA,Y.BESSHO,AUTH 2 K.HANAWA-SUETSUGU,T.YOSHIKAWA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN MYO-INOSITOLTITL 2 MONOPHOSPHATASE 2, THE PRODUCT OF THE PUTATIVETITL 3 SUSCEPTIBILITY GENE FOR BIPOLAR DISORDER,TITL 4 SCHIZOPHRENIA, AND FEBRILE SEIZURESREF PROTEINS V. 67 732 2007REFN ISSN 0887-3585PMID 17340635DOI […]
General Structure Information 2q5e CTDSP2 crystal structure of human carboxy-terminal domain rna polymerase ii polypeptide a small phosphatase 2 2.51Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4bej DNM1L nucleotide-free dynamin 1-like protein (dnm1l, drp1, dlp1) 3.48Å AUTH C.FROHLICH,S.GRABIGER,D.SCHWEFEL,K.FAELBER,E.ROSENBAUM,AUTH 2 J.MEARS,O.ROCKS,O.DAUMKETITL STRUCTURAL INSIGHTS INTO OLIGOMERIZATION AND MITOCHONDRIALTITL 2 REMODELLING OF DYNAMIN 1-LIKE PROTEIN.REF EMBO J. V. 32 1280 2013REFN ISSN 0261-4189PMID 23584531DOI 10.1038/EMBOJ.2013.74 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k4p INPPL1 solution structure of ship2-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL NMR STUDIES OF A HETEROTYPIC SAM-SAM DOMAINTITL 2 ASSOCIATION: THE INTERACTION BETWEEN THE LIPIDTITL 3 PHOSPHATASE SHIP2 AND THE EPHA2 RECEPTOR.REF BIOCHEMISTRY V. 47 12721 2008REFN ISSN 0006-2960PMID 18991394DOI 10.1021/BI801713F Variant Set Distributions Mapped Variants
General Structure Information 3t0o RNASET2 crystal structure analysis of human rnase t2 1.59Å AUTH A.THORN,R.STEINFELD,M.ZIEGENBEIN,M.GRAPP,H.H.HSIAO,H.URLAUB,AUTH 2 G.M.SHELDRICK,J.GARTNER,R.KRATZNERTITL STRUCTURE AND ACTIVITY OF THE ONLY HUMAN RNASE T2.REF NUCLEIC ACIDS RES. V. 40 8733 2012REFN ISSN 0305-1048PMID 22735700DOI 10.1093/NAR/GKS614 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1n3c OGG1 structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase 2.7Å AUTH D.P.NORMAN,S.J.CHUNG,G.L.VERDINETITL STRUCTURAL AND BIOCHEMICAL EXPLORATION OF ATITL 2 CRITICAL AMINO ACID IN HUMAN 8-OXOGUANINETITL 3 GLYCOSYLASEREF BIOCHEMISTRY V. 42 1564 2003REFN ISSN 0006-2960PMID 12578369DOI 10.1021/BI026823D Variant Set Distributions Mapped Variants
General Structure Information 2ooq PTPRT crystal structure of the human receptor phosphatase ptprt 1.8Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants