Assessment of Structural Intolerance and Durability
General Structure Information 1lcy HTRA2 crystal structure of the mitochondrial serine protease htra2 2.0Å AUTH W.LI,S.M.SRINIVASULA,J.CHAI,P.LI,J.W.WU,Z.ZHANG,E.S.ALNEMRI,AUTH 2 Y.SHITITL STRUCTURAL INSIGHTS INTO THE PRO-APOPTOTIC FUNCTION OFTITL 2 MITOCHONDRIAL SERINE PROTEASE HTRA2/OMI.REF NAT.STRUCT.BIOL. V. 9 436 2002REFN ISSN 1072-8368PMID 11967569DOI 10.1038/NSB795 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4a69 HDAC3 structure of hdac3 bound to corepressor and inositol tetraphosphate 2.06Å AUTH P.J.WATSON,L.FAIRALL,G.M.SANTOS,J.W.R.SCHWABETITL STRUCTURE OF HDAC3 BOUND TO CO-REPRESSOR AND INOSITOLTITL 2 TETRAPHOSPHATE.REF NATURE V. 481 335 2012REFN ISSN 0028-0836PMID 22230954DOI 10.1038/NATURE10728 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ifa FBP2 human muscle fructose-1,6-bisphosphatase e69q mutant in complex with amp 1.93Å AUTH M.ZARZYCKI,R.KOLODZIEJCZYK,E.MACIASZCZYK-DZIUBINSKA,AUTH 2 R.WYSOCKI,M.JASKOLSKI,A.DZUGAJTITL STRUCTURE OF E69Q MUTANT OF HUMAN MUSCLETITL 2 FRUCTOSE-1,6-BISPHOSPHATASEREF ACTA CRYSTALLOGR.,SECT.D V. 67 1028 2011REFN ISSN 0907-4449PMID 22120740DOI 10.1107/S090744491104385X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qq2 ACOT7 crystal structure of c-terminal domain of human acyl-coa thioesterase 7 2.8Å AUTH R.BUSAM,L.LEHTIO,C.H.ARROWSMITH,H.BERGLUND,R.COLLINS,AUTH 2 L.G.DAHLGREN,M.D.HERMAN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRESLUND,M.HAMMARSTROM,B.M.HALLBERG,L.HOLMBERG-SCHIAVONE,AUTH 4 I.JOHANSSON,A.KALLAS,T.KARLBERG,T.KOTENYOVA,M.MOCHE,AUTH 5 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 C.PERSSONTITL HUMAN ACYL-COA THIOESTERASE 7.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2mk2 INPPL1 solution nmr structure of n-terminal domain (sh2 domain) of human inositol polyphosphate phosphatase-like protein 1 (inppl1) (fragment 20-117), northeast structural genomics consortium target hr9134a -1.0Å AUTH Y.YANG,T.A.RAMELOT,H.JANJUA,R.XIAO,J.K.EVERETT,AUTH 2 G.T.MONTELIONE,M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF N-TERMINAL DOMAIN (SH2 DOMAIN) OFTITL 2 HUMAN INOSITOL POLYPHOSPHATE PHOSPHATASE-LIKE PROTEIN 1TITL 3 (INPPL1) (FRAGMENT 20-117), NORTHEAST […]
General Structure Information 3geb EYA2 crystal structure of edeya2 2.4Å AUTH S.J.KIM,D.G.JEONG,S.K.JUNG,E.R.SEONGTITL STRUCTURE OF EDEYA2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hhl CTDSPL crystal structure of the human small ctd phosphatase 3 isoform 1 2.1Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Mapped Variants
General Structure Information 2xri ERI3 crystal structure of human eri1 exoribonuclease 3 2.15Å AUTH M.WELIN,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 A.G.THORSELL,L.TRESAUGUES,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN ERI1 EXORIBONUCLEASE 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h11 CFLAR zymogen caspase-8:c-flipl protease domain complex 1.9Å AUTH J.W.YU,P.D.JEFFREY,Y.SHITITL MECHANISM OF PROCASPASE-8 ACTIVATION BY C-FLIPL.REF PROC.NATL.ACAD.SCI.USA V. 106 8169 2009REFN ISSN 0027-8424PMID 19416807DOI 10.1073/PNAS.0812453106 Variant Set Distributions Mapped Variants
General Structure Information 4a9c INPPL1 crystal structure of human ship2 in complex with biphenyl 2,3,4,5,6-pentakisphosphate 2.1Å AUTH S.J.MILLS,C.PERSSON,G.COZIER,M.P.THOMAS,L.TRESAUGUES,AUTH 2 C.ERNEUX,A.M.RILEY,P.NORDLUND,B.V.L.POTTERTITL A SYNTHETIC POLYPHOSPHOINOSITIDE HEADGROUP SURROGATE INTITL 2 COMPLEX WITH SHIP2 PROVIDES A RATIONALE FOR DRUG DISCOVERY.REF ACS CHEM.BIOL. V. 7 822 2012REFN ISSN 1554-8929PMID 22330088DOI 10.1021/CB200494D Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]