Assessment of Structural Intolerance and Durability
General Structure Information 4f91 SNRNP200 brr2 helicase region 2.7Å AUTH K.F.SANTOS,S.M.JOVIN,G.WEBER,V.PENA,R.LUHRMANN,M.C.WAHLTITL STRUCTURAL BASIS FOR FUNCTIONAL COOPERATION BETWEEN TANDEMTITL 2 HELICASE CASSETTES IN BRR2-MEDIATED REMODELING OF THETITL 3 SPLICEOSOME.REF PROC.NATL.ACAD.SCI.USA V. 109 17418 2012REFN ISSN 0027-8424PMID 23045696DOI 10.1073/PNAS.1208098109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lfv PDE5A crystal structure of unliganded pde5a gaf domain 2.8Å AUTH H.WANG,H.ROBINSON,H.KETITL CONFORMATION CHANGES, N-TERMINAL INVOLVEMENT, AND CGMPTITL 2 SIGNAL RELAY IN THE PHOSPHODIESTERASE-5 GAF DOMAIN.REF J.BIOL.CHEM. V. 285 38149 2010REFN ISSN 0021-9258PMID 20861010DOI 10.1074/JBC.M110.141614 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hu6 SPOP structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: spopmathx/btb/3-box-pucsbc1 2.7Å AUTH M.ZHUANG,M.F.CALABRESE,J.LIU,M.B.WADDELL,A.NOURSE,AUTH 2 M.HAMMEL,D.J.MILLER,H.WALDEN,D.M.DUDA,S.N.SEYEDIN,AUTH 3 T.HOGGARD,J.W.HARPER,K.P.WHITE,B.A.SCHULMANTITL STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTSTITL 2 INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITINTITL 3 LIGASES.REF MOL.CELL V. 36 39 2009REFN ISSN 1097-2765PMID 19818708DOI 10.1016/J.MOLCEL.2009.09.022 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3mtg AHCYL1 crystal structure of human s-adenosyl homocysteine hydrolase-like 1 protein 2.64Å AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,P.NORDLUND,T.NYMAN,C.PERSSON,P.SCHUTZ,AUTH 5 A.G.THORSELL,L.TRESAUGUES,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN S-ADENOSYL HOMOCYSTEINETITL 2 HYDROLASE-LIKE 1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2c46 RNGTT crystal structure of the human rna guanylyltransferase and 5-phosphatase 1.6Å AUTH J.DEBRECZENI,C.JOHANSSON,E.LONGMAN,O.GILEADI,P.SAVITSKYSMEE,AUTH 2 C.SMEE,G.BUNKOCZI,E.UGOCHUKWU,F.VON DELFT,M.SUNDSTROM,AUTH 3 J.WEIGELT,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN RNA GUANYLYLTRANSFERASE ANDTITL 2 5-PHOSPHATASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4c0d CNOT3 structure of the not module of the human ccr4-not complex (cnot1-cnot2-cnot3) 3.2Å AUTH A.BOLAND,Y.CHEN,T.RAISCH,S.JONAS,D.KUZUOGLU-OZTURK,AUTH 2 L.WOHLBOLD,O.WEICHENRIEDER,E.IZAURRALDETITL STRUCTURE AND ASSEMBLY OF THE NOT MODULE OF THE HUMANTITL 2 CCR4-NOT COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1289 2013REFN ISSN 1545-9993PMID 24121232DOI 10.1038/NSMB.2681 Variant Set Distributions Mapped Variants
General Structure Information 2mbc PTP4A3 solution structure of human holo-prl-3 in complex with vanadate -1.0Å AUTH K.KIM,J.H.SONG,J.JEE,M.R.SHEEN,C.LEE,T.G.LEE,S.RO,J.M.CHO,AUTH 2 W.LEE,T.YAMAZAKI,Y.H.JEON,C.CHEONGTITL STRUCTURE OF HUMAN PRL-3, THE PHOSPHATASE ASSOCIATED WITHTITL 2 CANCER METASTASISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i4i DDX3X crystal structure of human dead-box rna helicase ddx3x 2.2Å AUTH M.HOGBOM,R.COLLINS,S.VAN DEN BERG,R.-M.JENVERT,T.KARLBERG,AUTH 2 T.KOTENYOVA,A.FLORES,G.B.KARLSSON HEDESTAM,AUTH 3 L.H.HOLMBERG SCHIAVONETITL CRYSTAL STRUCTURE OF CONSERVED DOMAINS 1 AND 2 OF THE HUMANTITL 2 DEAD-BOX HELICASE DDX3X IN COMPLEX WITH THE MONONUCLEOTIDETITL 3 AMPREF J.MOL.BIOL. V. 372 150 2007REFN ISSN 0022-2836PMID 17631897DOI 10.1016/J.JMB.2007.06.050 […]
General Structure Information 4iqy MACROD2 crystal structure of the human protein-proximal adp-ribosyl-hydrolase macrod2 1.55Å AUTH G.JANKEVICIUS,M.HASSLER,B.GOLIA,V.RYBIN,M.ZACHARIAS,AUTH 2 G.TIMINSZKY,A.G.LADURNERTITL A FAMILY OF MACRODOMAIN PROTEINS REVERSES CELLULARTITL 2 MONO-ADP-RIBOSYLATION.REF NAT.STRUCT.MOL.BIOL. V. 20 508 2013REFN ISSN 1545-9993PMID 23474712DOI 10.1038/NSMB.2523 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2j1l RHOD crystal structure of human rho-related gtp-binding protein rhod 2.5Å AUTH A.C.W.PIKE,C.JOHANSSON,C.GILEADI,F.H.NIESEN,F.SOBOTT,AUTH 2 G.SCHOCH,J.ELKINS,C.SMEE,F.GORREC,S.WATT,J.BRAY,AUTH 3 A.P.TURNBULL,F.VON DELFT,C.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 4 M.SUNDSTROM,D.DOYLETITL CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEINTITL 2 RHODREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants