General Structure Information
| PDB ID | 3lfv |
| HGNC Gene Label(s) | PDE5A |
| Structure Name | crystal structure of unliganded pde5a gaf domain |
| Resolution | 2.8Å |
| Reference | AUTH H.WANG,H.ROBINSON,H.KETITL CONFORMATION CHANGES, N-TERMINAL INVOLVEMENT, AND CGMPTITL 2 SIGNAL RELAY IN THE PHOSPHODIESTERASE-5 GAF DOMAIN.REF J.BIOL.CHEM. V. 285 38149 2010REFN ISSN 0021-9258PMID 20861010DOI 10.1074/JBC.M110.141614 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 370 |
| Number Of SNVs | 83 |
| Number Of Permutations | 64224 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.019 |
| p-value | 0.236 |
COSMIC
| Number Of Residues | 370 |
| Number Of SNVs | 3 |
| Number Of Permutations | 44 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.333 |
| p-value | 0.975 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 45.0 |
| K Statistic | 0.257 |
| p-value | 0.995 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
