1N3C.A | OGG1 – ASTRID

1N3C.A | OGG1

General Structure Information

PDB ID	1n3c
HGNC Gene Label(s)	OGG1
Structure Name	structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Resolution	2.7Å
Reference	AUTH D.P.NORMAN,S.J.CHUNG,G.L.VERDINETITL STRUCTURAL AND BIOCHEMICAL EXPLORATION OF ATITL 2 CRITICAL AMINO ACID IN HUMAN 8-OXOGUANINETITL 3 GLYCOSYLASEREF BIOCHEMISTRY V. 42 1564 2003REFN ISSN 0006-2960PMID 12578369DOI 10.1021/BI026823D

Variant Set Distributions

ExAC Variants

Number Of Residues	311
Number Of SNVs	91
Number Of Permutations	14939
Optimal Distance Threshold	8.0
K Statistic	0.028
p-value	0.512

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
3:9792005		G>E	A:12	(25.89, -7.31, 39.17)
3:9792008		H>R	A:13	(26.19, -3.35, 37.76)
3:9792020		A>V	A:17	(31.71, -8.86, 27.72)
3:9792041		A>V	A:24	(20.59, -5.59, 22.57)
3:9792046		I>L	A:26	(19.54, 0.21, 18.98)
3:9792050		P>L	A:27	(20.45, 0.84, 15.09)
3:9792062		S>C	A:31	(26.93, 10.66, 15.04)
3:9792071		R>L	A:34	(29.23, 11.02, 22.57)
3:9792079		L>V	A:37	(28.56, 14.03, 25.70)
3:9792095	rs375516876	G>E	A:42	(21.95, 17.69, 33.20)
3:9792097	rs139595187	Q>E	A:43	(19.53, 16.30, 30.03)
3:9792098		Q>L	A:43	(19.53, 16.30, 30.03)
3:9792106		R>W	A:46	(17.75, 8.45, 38.21)
3:9792107	rs104893751	R>Q	A:46	(17.75, 8.45, 38.21)
3:9792635		R>S	A:48	(25.09, 7.26, 38.47)
3:9792643	rs147083396	S>T	A:51	(31.22, 0.40, 34.19)
3:9792651		H>Y	A:54	(29.14, 0.01, 30.52)
3:9792664		V>A	A:58	(15.61, 4.17, 36.00)
3:9792670		A>V	A:60	(10.70, 2.85, 32.24)
3:9792684	COSM585101 COSM1143431	T>A	A:65	(23.06, -1.04, 31.29)
3:9792694		Q>L	A:68	(28.14, 3.63, 22.62)
3:9792696		T>A	A:69	(29.70, 0.54, 19.51)
3:9792697		T>S	A:69	(29.70, 0.54, 19.51)
3:9792699	rs138037313	E>K	A:70	(31.50, 3.93, 16.20)
3:9792700		E>G	A:70	(31.50, 3.93, 16.20)
3:9792718		T>I	A:76	(20.90, -4.38, 29.51)
3:9792754		P>H	A:88	(16.29, -6.79, 25.52)
3:9792757		T>I	A:89	(11.95, -6.92, 24.30)
3:9792765		E>K	A:92	(11.82, -3.91, 26.59)
3:9792775		A>V	A:95	(11.79, 2.67, 25.30)
3:9792777	rs138111256	V>M	A:96	(15.49, 3.22, 24.51)
3:9792780	COSM1049166 COSM1218412 COSM1049165 COSM1218413	R>S	A:97	(14.24, 4.40, 19.13)
3:9792784		K>R	A:98	(10.22, 7.19, 22.88)
3:9792796		L>R	A:102	(16.72, 7.72, 18.12)
3:9792798	rs139632793	D>H	A:103	(12.84, 9.13, 15.13)
3:9792800		D>E	A:103	(12.84, 9.13, 15.13)
3:9792805		T>N	A:105	(18.31, 13.37, 12.48)
3:9792807		L>V	A:106	(21.61, 15.13, 15.81)
3:9792810		A>T	A:107	(22.60, 15.40, 11.32)
3:9792811		A>V	A:107	(22.60, 15.40, 11.32)
3:9792814		Q>R	A:108	(19.47, 16.80, 9.03)
3:9792822	rs377605863	H>Y	A:111	(23.45, 20.97, 7.87)
3:9792826		H>R	A:112	(19.83, 24.45, 10.25)
3:9792843		S>P	A:118	(29.95, 29.83, 12.09)
3:9792851		F>L	A:120	(26.80, 24.69, 16.37)
3:9792866		Q>H	A:125	(33.23, 19.03, 15.56)
3:9793460		R>Q	A:131	(20.03, 13.16, 20.95)
3:9793469	rs371071998	R>Q	A:134	(9.80, 12.57, 25.16)
3:9793471		Q>E	A:135	(12.95, 13.61, 30.86)
3:9793480		I>V	A:138	(6.78, 14.10, 37.82)
3:9793483		E>K	A:139	(12.04, 12.29, 36.85)
3:9793487		C>Y	A:140	(11.76, 16.81, 35.07)
3:9793520		N>S	A:151	(26.12, 21.80, 41.87)
3:9793528	rs374572934	R>C	A:154	(23.72, 19.83, 46.17)
3:9793532		I>T	A:155	(21.48, 18.22, 41.65)
3:9793549		R>W	A:161	(19.93, 11.88, 49.02)
3:9793550		R>Q	A:161	(19.93, 11.88, 49.02)
3:9793553		L>R	A:162	(14.00, 12.07, 46.72)
3:9793561		A>P	A:165	(13.06, 7.89, 50.51)
3:9793573		R>W	A:169	(13.41, -1.64, 47.13)
3:9793574		R>Q	A:169	(13.41, -1.64, 47.13)
3:9793590		D>E	A:174	(26.58, -4.83, 43.13)
3:9793597	rs144249605	T>S	A:177	(19.23, -0.06, 45.62)
3:9793601	rs570953488	Y>C	A:178	(19.22, 0.97, 40.82)
3:9793604		H>R	A:179	(14.73, 3.32, 44.60)
3:9793625		A>G	A:186	(4.73, 10.81, 48.15)
3:9796396		V>M	A:192	(8.13, 15.14, 53.13)
3:9796400		E>G	A:193	(9.64, 20.17, 54.38)
3:9796405	rs545825409	H>Y	A:195	(12.91, 12.85, 55.24)
3:9796411	rs139716494	R>W	A:197	(14.89, 20.83, 55.26)
3:9796426		G>S	A:202	(17.05, 22.58, 51.48)
3:9796432	rs376536141	R>C	A:204	(16.12, 23.67, 47.02)
3:9796438	rs202182784	R>C	A:206	(8.63, 24.88, 52.18)
3:9796447		S>G	A:209	(6.01, 19.78, 49.38)
3:9796451		A>V	A:210	(4.47, 22.59, 47.70)
3:9796456		A>P	A:212	(3.03, 18.21, 45.16)
3:9796460		R>Q	A:213	(1.05, 19.32, 49.58)
3:9796483	rs373826669	G>R	A:221	(-2.82, 16.58, 38.58)
3:9796499	rs202010194	Q>P	A:226	(0.17, 14.13, 31.69)
3:9796508	rs1805373	R>Q	A:229	(3.99, 15.89, 26.85)
3:9796510	rs55667729	E>Q	A:230	(-1.15, 18.05, 24.31)
3:9796531		H>Y	A:237	(6.97, 29.11, 30.91)
3:9798197	rs560032348	A>P	A:264	(13.01, 26.00, 24.89)
3:9798198		A>D	A:264	(13.01, 26.00, 24.89)
3:9798206	rs571850004	V>M	A:267	(18.53, 31.56, 30.38)
3:9798216		H>R	A:270	(26.53, 28.00, 32.07)
3:9798228		I>T	A:274	(27.87, 30.92, 25.66)
3:9798257		T>A	A:284	(18.93, 45.71, 23.05)
3:9798261	COSM1425799 COSM4120767 COSM1425798 COSM1425797 COSM1425800	T>M	A:285	(15.01, 45.81, 24.13)
3:9798270	rs3219012	A>V	A:288	(19.87, 45.88, 31.96)
3:9798278		P>S	A:291	(21.51, 39.06, 34.51)
3:9798279	COSM3916792 COSM3916790 COSM3916791 COSM3916789 COSM3916793	P>L	A:291	(21.51, 39.06, 34.51)
3:9798284		P>S	A:293	(13.90, 39.28, 34.25)
3:9798290	rs149295536	T>A	A:295	(17.80, 40.33, 30.07)
3:9798462		R>W	A:304	(13.97, 31.24, 20.57)
3:9798463	rs376666435	R>Q	A:304	(13.97, 31.24, 20.57)
3:9798467		S>R	A:305	(16.35, 33.83, 16.07)
3:9798478	rs200356068	P>R	A:309	(12.55, 25.55, 15.77)
3:9798483		A>T	A:311	(16.97, 26.09, 20.01)
3:9798493		A>G	A:314	(21.38, 23.82, 20.38)
3:9798499	rs200462706	A>V	A:316	(22.40, 21.45, 24.62)
3:9807511	rs576720672	F>L	A:323	(29.77, 21.52, 31.54)