Assessment of Structural Intolerance and Durability
General Structure Information 1zs9 ENOPH1 crystal structure of human enolase-phosphatase e1 1.7Å AUTH H.WANG,H.PANG,M.BARTLAM,Z.RAOTITL CRYSTAL STRUCTURE OF HUMAN E1 ENZYME AND ITSTITL 2 COMPLEX WITH A SUBSTRATE ANALOG REVEALS THETITL 3 MECHANISM OF ITS PHOSPHATASE/ENOLASEREF J.MOL.BIOL. V. 348 917 2005REFN ISSN 0022-2836PMID 15843022DOI 10.1016/J.JMB.2005.01.072 Variant Set Distributions Mapped Variants
General Structure Information 2xph SENP1 crystal structure of human senp1 with the bound cobalt 2.4Å AUTH V.RIMSA,T.EADSFORTH,R.T.HAY,W.N.HUNTERTITL THE ROLE OF CO2+ IN THE CRYSTALLIZATION OF HUMAN SENP1 ANDTITL 2 COMMENTS ON THE LIMITATIONS OF AUTOMATED REFINEMENTTITL 3 PROTOCOLSREF ACTA CRYSTALLOGR.,SECT.F V. 67 442 2011REFN ISSN 1744-3091PMID 21505236DOI 10.1107/S1744309111005835 Variant Set Distributions Mapped Variants
General Structure Information 1×51 MUTYH solution structure of the nudix domain from human a/g- specific adenine dna glycosylase alpha-3 splice isoform -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NUDIX DOMAIN FROM HUMANTITL 2 A/G-SPECIFIC ADENINE DNA GLYCOSYLASE ALPHA-3TITL 3 SPLICE ISOFORMREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1m6d CTSF crystal structure of human cathepsin f 1.7Å AUTH J.R.SOMOZA,J.T.PALMER,J.D.HOTITL THE CRYSTAL STRUCTURE OF HUMAN CATHEPSIN F AND ITSTITL 2 IMPLICATIONS FOR THE DEVELOPMENT OF NOVEL IMMUNOMODULATORSREF J.MOL.BIOL. V. 322 559 2002REFN ISSN 0022-2836PMID 12225749DOI 10.1016/S0022-2836(02)00780-5 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2boa CPA4 human procarboxypeptidase a4. 2.2Å AUTH R.GARCIA-CASTELLANOS,R.BONET-FIGUEREDO,I.PALLARES,AUTH 2 S.VENTURA,F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUTHTITL DETAILED MOLECULAR COMPARISON BETWEEN THETITL 2 INHIBITION MODE OF A/B-TYPE CARBOXYPEPTIDASES INTITL 3 THE ZYMOGEN STATE AND BY THE ENDOGENOUS INHIBITORTITL 4 LATEXIN.REF CELL.MOL.LIFE SCI. V. 62 1996 2005REFN ISSN 1420-682XPMID 16091843DOI 10.1007/S00018-005-5174-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1deu CTSZ crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine 1.7Å AUTH J.SIVARAMAN,D.K.NAGLER,R.ZHANG,R.MENARD,M.CYGLERTITL CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINETITL 2 PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVETITL 3 SITE CYSTEINE.REF J.MOL.BIOL. V. 295 939 2000REFN ISSN 0022-2836PMID […]
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2oxc DDX20 human dead-box rna helicase ddx20, dead domain in complex with adp 1.3Å AUTH T.KARLBERG,D.OGG,C.H ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,B.M.HALLBERG,AUTH 4 M.HAMMARSTROM,M.HOGBOM,I.JOHANSSON,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.MOCHE,P.NORDLUND,T.NYMAN,C.PERSSON,AUTH 6 J.SAGEMARK,P.STENMARK,M.SUNDSTROM,A.G.THORSELL,AUTH 7 S.VAN DEN BERG,J.WEIGELT,L.HOLMBERG-SCHIAVONETITL HUMAN DEAD-BOX RNA HELICASE DDX20REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3zrh ZRANB1 crystal structure of the lys29, lys33-linkage-specific trabid otu deubiquitinase domain reveals an ankyrin-repeat ubiquitin binding domain (ankubd) 2.23Å AUTH J.D.F.LICCHESI,J.MIESZCZANEK,T.E.T.MEVISSEN,T.J.RUTHERFORD,AUTH 2 M.AKUTSU,S.VIRDEE,F.E.OUALID,J.W.CHIN,H.OVAA,M.BIENZ,AUTH 3 D.KOMANDERTITL AN ANKYRIN-REPEAT UBIQUITIN-BINDING DOMAIN DETERMINESTITL 2 TRABIDS SPECIFICITY FOR ATYPICAL UBIQUITIN CHAINS.REF NAT.STRUCT.MOL.BIOL. V. 19 62 2011REFN ISSN 1545-9993PMID 22157957DOI 10.1038/NSMB.2169 Variant Set Distributions Ripley’s K […]
General Structure Information 3lgg CECR1 crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin 2.5Å AUTH A.V.ZAVIALOV,X.YU,D.SPILLMANN,G.LAUVAU,A.V.ZAVIALOVTITL STRUCTURAL BASIS FOR THE GROWTH FACTOR ACTIVITY OF HUMANTITL 2 ADENOSINE DEAMINASE ADA2.REF J.BIOL.CHEM. V. 285 12367 2010REFN ISSN 0021-9258PMID 20147294DOI 10.1074/JBC.M109.083527 Variant Set Distributions Ripley’s K Analysis […]