Assessment of Structural Intolerance and Durability
General Structure Information 3ews DDX19B human dead-box rna-helicase ddx19 in complex with adp 2.7Å AUTH R.COLLINS,T.KARLBERG,L.LEHTIO,P.SCHUTZ,AUTH 2 S.VAN DEN BERG,L.G.DAHLGREN,M.HAMMARSTROM,AUTH 3 J.WEIGELT,H.SCHULERTITL THE DEXD/H-BOX RNA HELICASE DDX19 IS REGULATED BYTITL 2 AN {ALPHA}-HELICAL SWITCH.REF J.BIOL.CHEM. V. 284 10296 2009REFN ISSN 0021-9258PMID 19244245DOI 10.1074/JBC.C900018200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2oq5 TMPRSS11E crystal structure of desc1, a new member of the type ii transmembrane serine proteinases family 1.61Å AUTH O.J.P.KYRIELEIS,R.HUBER,E.ONG,R.OEHLER,M.HUNTER,AUTH 2 E.L.MADISON,U.JACOBTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OFTITL 2 DESC1, A NEW MEMBER OF THE TYPE II TRANSMEMBRANETITL 3 SERINE PROTEINASE FAMILY.REF FEBS J. V. 274 2148 2007REFN ISSN 1742-464XPMID 17388811DOI […]
General Structure Information 2i7t CPSF3 structure of human cpsf-73 2.1Å AUTH C.R.MANDEL,S.KANEKO,H.ZHANG,D.GEBAUER,V.VETHANTHAM,AUTH 2 J.L.MANLEY,L.TONGTITL POLYADENYLATION FACTOR CPSF-73 IS THE PRE-MRNATITL 2 3-END-PROCESSING ENDONUCLEASE.REF NATURE V. 444 953 2006REFN ISSN 0028-0836PMID 17128255DOI 10.1038/NATURE05363 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3jyh DPP7 human dipeptidyl peptidase dpp7 2.19Å AUTH E.DOBROVETSKY,A.DONG,A.SEITOVA,L.CROMBETT,S.PAGANON,AUTH 2 D.COSSAR,A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,AUTH 3 A.HASSEL,L.SHEWCHUK,A.BOCHKAREVTITL HUMAN DIPEPTIDYL PEPTIDASE DPP7REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jtc PROCR importance of mg2+ in the ca2+-dependent folding of the gamma- carboxyglutamic acid domains of vitamin k-dependent clotting and anticlotting proteins 1.6Å AUTH K.VADIVEL,S.AGAH,A.S.MESSER,D.CASCIO,M.S.BAJAJ,AUTH 2 S.KRISHNASWAMY,C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL STRUCTURAL AND FUNCTIONAL STUDIES OF GAMMA-CARBOXYGLUTAMICTITL 2 ACID DOMAINS OF FACTOR VIIA AND ACTIVATED PROTEIN C: ROLE OFTITL 3 MAGNESIUM AT PHYSIOLOGICAL CALCIUM.REF J.MOL.BIOL. V. […]
General Structure Information 3qwl TBC1D7 crystal structure of human tbc1 domain family member 7 1.9Å AUTH X.GUAN,W.TEMPEL,Y.TONG,A.K.WERNIMONT,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILY MEMBER 7REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3n5n MUTYH crystal structure analysis of the catalytic domain and interdomain connector of human muty homologue 2.3Å AUTH P.J.LUNCSFORD,D.Y.CHANG,G.SHI,J.BERNSTEIN,A.MADABUSHI,AUTH 2 D.N.PATTERSON,A.L.LU,E.A.TOTHTITL A STRUCTURAL HINGE IN EUKARYOTIC MUTY HOMOLOGUES MEDIATESTITL 2 CATALYTIC ACTIVITY AND RAD9-RAD1-HUS1 CHECKPOINT COMPLEXTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 403 351 2010REFN ISSN 0022-2836PMID 20816984DOI 10.1016/J.JMB.2010.08.045 Variant Set Distributions Ripley’s K […]
General Structure Information 3sop SEPT3 crystal structure of human septin 3 gtpase domain 2.88Å AUTH J.N.MACEDO,N.F.VALADARES,I.A.MARQUES,F.M.FERREIRA,AUTH 2 J.C.DAMALIO,H.M.PEREIRA,R.C.GARRATT,A.P.ARAUJOTITL THE STRUCTURE AND PROPERTIES OF SEPTIN 3: A POSSIBLE MISSINGTITL 2 LINK IN SEPTIN FILAMENT FORMATION.REF BIOCHEM.J. V. 450 95 2013REFN ISSN 0264-6021PMID 23163726DOI 10.1042/BJ20120851 Variant Set Distributions Mapped Variants
General Structure Information 4bqm GLS2 crystal structure of human liver-type glutaminase, catalytic domain 2.18Å AUTH I.M.FERREIRA,M.VOLLMAR,T.KROJER,C.STRAIN-DAMERELL,S.FROESE,AUTH 2 D.COUTANDIN,E.WILLIAMS,N.BURGESS-BROWN,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,C.BOUNTRA,A.EDWARDS,S.M.G.DIAS,AUTH 4 A.L.B.AMBROSIO,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN LIVER-TYPE GLUTAMINASE,TITL 2 CATALYTIC DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4dyo DNPEP crystal structure of human aspartyl aminopeptidase (dnpep) in complex with aspartic acid hydroxamate 2.2Å AUTH A.CHAIKUAD,E.S.PILKA,A.D.RISO,F.V.DELFT,K.L.KAVANAGH,AUTH 2 C.VENIEN-BRYAN,U.OPPERMANN,W.W.YUETITL STRUCTURE OF HUMAN ASPARTYL AMINOPEPTIDASE COMPLEXED WITHTITL 2 SUBSTRATE ANALOGUE: INSIGHT INTO CATALYTIC MECHANISM,TITL 3 SUBSTRATE SPECIFICITY AND M18 PEPTIDASE FAMILY.REF BMC STRUCT.BIOL. V. 12 14 2012REFN ESSN 1472-6807PMID 22720794DOI 10.1186/1472-6807-12-14 Variant […]