General Structure Information
| PDB ID | 2i7t |
| HGNC Gene Label(s) | CPSF3 |
| Structure Name | structure of human cpsf-73 |
| Resolution | 2.1Å |
| Reference | AUTH C.R.MANDEL,S.KANEKO,H.ZHANG,D.GEBAUER,V.VETHANTHAM,AUTH 2 J.L.MANLEY,L.TONGTITL POLYADENYLATION FACTOR CPSF-73 IS THE PRE-MRNATITL 2 3-END-PROCESSING ENDONUCLEASE.REF NATURE V. 444 953 2006REFN ISSN 0028-0836PMID 17128255DOI 10.1038/NATURE05363 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 404 |
| Number Of SNVs | 48 |
| Number Of Permutations | 27533 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.194 |
| p-value | 0.007 |
COSMIC
| Number Of Residues | 404 |
| Number Of SNVs | 3 |
| Number Of Permutations | 292 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.667 |
| p-value | 0.68 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 48 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.246 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
