3JYH.A | DPP7 – ASTRID

3JYH.A | DPP7

General Structure Information

PDB ID	3jyh
HGNC Gene Label(s)	DPP7
Structure Name	human dipeptidyl peptidase dpp7
Resolution	2.19Å
Reference	AUTH E.DOBROVETSKY,A.DONG,A.SEITOVA,L.CROMBETT,S.PAGANON,AUTH 2 D.COSSAR,A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,AUTH 3 A.HASSEL,L.SHEWCHUK,A.BOCHKAREVTITL HUMAN DIPEPTIDYL PEPTIDASE DPP7REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	452
Number Of SNVs	155
Number Of Permutations	64565
Optimal Distance Threshold	6.0
K Statistic	0.012
p-value	0.7

COSMIC

Number Of Residues	452
Number Of SNVs	6
Number Of Permutations	532
Optimal Distance Threshold	17.0
K Statistic	0.067
p-value	0.603

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	155
Number Of COSMIC SNVs	5
Optimal Distance Threshold	17.0
K Statistic	-0.17
p-value	0.885

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:140008985		Q>H	A:37	(31.94, 1.20, -9.43)
9:140008984		Q>K	A:38	(29.06, 4.79, -6.08)
9:140008981		R>C	A:39	(30.41, 9.48, -8.22)
9:140008974		D>G	A:41	(32.71, 13.18, -3.19)
9:140008975	rs373395362	D>Y	A:41	(32.71, 13.18, -3.19)
9:140008960	rs200570503	E>Q	A:46	(38.13, 19.54, -7.10)
9:140008953		F>S	A:48	(38.40, 12.13, -3.54)
9:140008950		G>D	A:49	(37.11, 13.49, -8.60)
9:140008951	rs375476962	G>S	A:49	(37.11, 13.49, -8.60)
9:140008941		T>N	A:52	(34.82, 5.11, -8.35)
9:140008937		F>L	A:53	(32.98, 3.15, -3.83)
9:140008939		F>V	A:53	(32.98, 3.15, -3.83)
9:140008923		L>P	A:58	(22.16, -7.94, -1.84)
9:140008921		V>L	A:59	(19.69, -8.83, -6.28)
9:140008820		R>W	A:66	(10.62, -8.29, -15.71)
9:140008817		G>R	A:67	(6.76, -4.69, -15.67)
9:140008814		E>K	A:68	(4.52, -4.72, -12.91)
9:140008810	rs374905554	G>E	A:69	(7.10, -4.13, -10.47)
9:140008802		F>I	A:72	(9.86, -3.53, -2.49)
9:140008780		G>D	A:79	(26.37, -3.02, 8.44)
9:140008781	rs541974707	G>S	A:79	(26.37, -3.02, 8.44)
9:140008775		V>M	A:81	(23.94, -6.09, 3.65)
9:140008768		A>V	A:83	(22.09, -8.79, 8.39)
9:140008769	rs199586193	A>P	A:83	(22.09, -8.79, 8.39)
9:140008762		A>G	A:85	(18.62, -9.75, 4.59)
9:140008763		A>T	A:85	(18.62, -9.75, 4.59)
9:140008754		S>A	A:88	(14.37, -8.06, 7.01)
9:140008750	rs10747049	A>G	A:89	(11.54, -10.80, 5.75)
9:140008751		A>T	A:89	(11.54, -10.80, 5.75)
9:140008733		A>P	A:95	(7.66, -9.02, -2.66)
9:140008729		A>V	A:96	(5.75, -11.98, -3.09)
9:140008724	rs370554959	R>W	A:98	(2.46, -6.26, -3.32)
9:140008721		G>R	A:99	(6.15, -8.33, -7.60)
9:140008718		A>S	A:100	(8.91, -7.30, -6.14)
9:140008702		A>G	A:105	(21.97, -1.46, -0.01)
9:140008700		E>K	A:106	(26.48, -2.37, 1.90)
9:140008479		R>H	A:108	(29.60, 5.51, 1.66)
9:140008471	rs138978681	G>R	A:111	(31.62, -4.15, 5.06)
9:140008458		P>R	A:115	(35.73, 3.90, 0.06)
9:140008453		G>S	A:117	(39.33, -0.08, 2.07)
9:140008449	rs549765115	A>G	A:118	(40.89, -1.40, 5.06)
9:140008443	rs150267769	S>F	A:120	(38.09, 3.23, 5.35)
9:140008444		S>T	A:120	(38.09, 3.23, 5.35)
9:140008435		R>C	A:123	(42.67, 9.60, 13.15)
9:140008428		H>R	A:125	(41.37, 7.10, 5.61)
9:140008410		V>A	A:131	(23.74, 10.60, 6.04)
9:140008408		E>Q	A:132	(24.37, 13.68, 3.58)
9:140008402		A>T	A:134	(24.60, 7.43, 1.66)
9:140008393	rs375634482	D>N	A:137	(25.40, 6.19, -2.62)
9:140008386		A>E	A:139	(20.07, 7.59, -5.66)
9:140008387		A>P	A:139	(20.07, 7.59, -5.66)
9:140008365		R>P	A:146	(14.49, 2.93, -11.85)
9:140008356	rs373555528	L>R	A:149	(17.19, -3.94, -14.60)
9:140008353		G>E	A:150	(14.48, -1.97, -17.48)
9:140008354		G>R	A:150	(14.48, -1.97, -17.48)
9:140008351		A>T	A:151	(12.70, -0.10, -15.00)
9:140008331		I>M	A:157	(9.02, 1.41, -1.72)
9:140007943		G>E	A:164	(17.61, 2.70, 8.15)
9:140007931		S>N	A:168	(14.17, 5.24, 4.38)
9:140007915	rs189319790	M>I	A:173	(12.39, 13.56, 3.21)
9:140007905	COSM1472157	H>Y	A:177	(13.01, 12.14, -7.69)
9:140007886		L>P	A:183	(8.72, 1.16, 6.26)
9:140007883		A>V	A:184	(10.39, 3.74, 9.04)
9:140007884		A>T	A:184	(10.39, 3.74, 9.04)
9:140007880		A>V	A:185	(11.47, 0.95, 11.30)
9:140007875	COSM1107042	A>T	A:187	(13.19, 5.58, 13.50)
9:140007871		P>L	A:188	(15.48, 7.28, 16.01)
9:140007869	rs148168517	V>I	A:189	(14.01, 10.92, 13.70)
9:140007857		A>T	A:193	(18.31, 15.81, 16.24)
9:140007853		G>A	A:194	(18.23, 16.68, 19.81)
9:140007835		Q>L	A:200	(14.11, 8.03, 26.57)
9:140007827		R>W	A:203	(13.53, 5.55, 31.57)
9:140007821		V>I	A:205	(15.74, -0.03, 29.35)
9:140007817	rs201995932	T>K	A:206	(14.27, 0.54, 33.46)
9:140007814		A>V	A:207	(10.46, -0.10, 32.13)
9:140007815	rs532117944	A>P	A:207	(10.46, -0.10, 32.13)
9:140007687		R>Q	A:225	(24.54, -0.43, 47.15)
9:140007676	COSM1741667	D>N	A:229	(29.80, -0.34, 47.80)
9:140007671		L>F	A:230	(32.97, -4.13, 46.69)
9:140007663		Q>R	A:233	(34.83, -1.65, 50.49)
9:140007664		Q>K	A:233	(34.83, -1.65, 50.49)
9:140007660	rs145702438	G>E	A:234	(39.01, -2.24, 47.68)
9:140007562		T>M	A:238	(35.40, -9.61, 45.20)
9:140007557	COSM3905971	R>C	A:240	(39.22, -10.54, 38.51)
9:140007545		G>S	A:244	(34.12, -12.27, 35.78)
9:140007532		P>L	A:248	(42.85, -7.02, 36.50)
9:140007521		E>K	A:252	(37.29, 4.51, 37.86)
9:140007514		D>G	A:254	(38.26, -0.44, 35.63)
9:140007508		T>I	A:256	(33.03, 3.21, 34.04)
9:140007495		M>I	A:260	(29.33, 1.24, 29.95)
9:140007496		M>T	A:260	(29.33, 1.24, 29.95)
9:140007497		M>L	A:260	(29.33, 1.24, 29.95)
9:140007491	rs373456341	A>T	A:262	(26.33, -4.14, 32.06)
9:140007487		R>Q	A:263	(24.40, 0.98, 30.32)
9:140007488	rs147834845	R>W	A:263	(24.40, 0.98, 30.32)
9:140007482		A>T	A:265	(22.87, -6.17, 28.46)
9:140007473	rs111226653	V>M	A:268	(20.81, -6.09, 23.79)
9:140007466	rs181036640	A>V	A:270	(15.16, -4.70, 25.08)
9:140007462	rs546250926	M>I	A:271	(16.84, -3.46, 21.23)
9:140007463		M>T	A:271	(16.84, -3.46, 21.23)
9:140007464		M>V	A:271	(16.84, -3.46, 21.23)
9:140007435		F>L	A:280	(20.15, -8.52, 14.27)
9:140007436		F>S	A:280	(20.15, -8.52, 14.27)
9:140007431		G>S	A:282	(22.63, -12.33, 18.93)
9:140007428		P>S	A:283	(22.70, -15.60, 20.02)
9:140007424		L>H	A:284	(18.99, -14.05, 22.10)
9:140007422		P>S	A:285	(16.43, -16.41, 24.01)
9:140007418		A>V	A:286	(12.58, -16.34, 23.84)
9:140007419		A>T	A:286	(12.58, -16.34, 23.84)
9:140007247	rs372674817	D>G	A:294	(14.25, -15.74, 35.29)
9:140007226		Q>R	A:301	(25.59, -14.22, 45.44)
9:140007224	rs368738117	R>G	A:302	(21.06, -9.80, 43.86)
9:140007217	rs139554508	T>M	A:304	(26.07, -14.07, 40.43)
9:140007214	rs142674168	G>E	A:305	(23.01, -12.37, 38.53)
9:140006674	rs544607733	Y>H	A:314	(28.34, -9.76, 26.85)
9:140006667		A>D	A:316	(25.58, -17.64, 24.63)
9:140006668		A>T	A:316	(25.58, -17.64, 24.63)
9:140006664	rs373746970	S>L	A:317	(28.19, -20.30, 24.18)
9:140006656		E>K	A:320	(33.24, -16.70, 27.13)
9:140006644	rs199861431	D>N	A:324	(37.51, -8.81, 28.05)
9:140006634		R>Q	A:327	(37.38, -7.20, 23.98)
9:140006635		R>W	A:327	(37.38, -7.20, 23.98)
9:140006619		C>Y	A:332	(31.54, 5.09, 22.19)
9:140006614		D>N	A:334	(26.52, 5.09, 20.91)
9:140006602		C>S	A:338	(29.47, 0.84, 18.75)
9:140006592		G>V	A:341	(35.09, -3.31, 14.49)
9:140006593	rs371790137	G>S	A:341	(35.09, -3.31, 14.49)
9:140006587	COSM1741666	D>N	A:343	(31.12, -2.00, 11.06)
9:140006584		A>T	A:344	(32.11, 0.27, 15.19)
9:140006472	rs374069416	E>K	A:354	(25.97, 13.85, 11.01)
9:140006468	rs566901491	I>T	A:355	(24.40, 10.79, 14.60)
9:140006469		I>F	A:355	(24.40, 10.79, 14.60)
9:140006454	rs145954715	A>T	A:360	(22.04, 9.21, 30.20)
9:140006445		N>Y	A:363	(20.68, 5.80, 40.05)
9:140006435		D>G	A:366	(17.82, 4.90, 35.65)
9:140006432	rs78671427	M>T	A:367	(18.10, 0.01, 36.57)
9:140006429		F>S	A:368	(20.93, 1.40, 34.60)
9:140006427		P>T	A:369	(24.82, 3.50, 36.93)
9:140006399		R>H	A:378	(29.70, 14.14, 21.02)
9:140006400	rs370313786	R>C	A:378	(29.70, 14.14, 21.02)
9:140006393		R>Q	A:380	(36.78, 16.13, 25.01)
9:140006394		R>W	A:380	(36.78, 16.13, 25.01)
9:140006388		C>R	A:382	(35.44, 12.97, 19.03)
9:140006382		D>N	A:384	(41.02, 12.68, 21.49)
9:140006378	rs139530173	T>I	A:385	(39.17, 9.24, 18.50)
9:140006369	rs573099531	V>A	A:388	(36.20, 15.42, 14.41)
9:140006360	rs200823070	R>Q	A:391	(29.30, 19.94, 12.17)
9:140006361		R>W	A:391	(29.30, 19.94, 12.17)
9:140006355	rs146349245	D>N	A:393	(22.89, 22.07, 15.58)
9:140006345		L>R	A:396	(17.41, 19.90, 13.03)
9:140006340		S>G	A:398	(19.49, 18.40, 6.98)
9:140006332		W>C	A:400	(12.77, 18.07, 6.86)
9:140006333	rs142321046	W>S	A:400	(12.77, 18.07, 6.86)
9:140006325		D>N	A:403	(8.59, 20.06, 10.52)
9:140006195	COSM1107038	A>T	A:407	(6.35, 15.05, 3.96)
9:140006183		I>F	A:411	(5.16, 4.03, 7.52)
9:140006178		F>L	A:412	(7.69, 7.16, 10.91)
9:140006173	rs202238625	N>S	A:414	(7.79, 2.45, 16.83)
9:140006171	COSM3848106	G>R	A:415	(7.81, -0.45, 19.73)
9:140006166		N>K	A:416	(5.82, -1.08, 23.48)
9:140006153	rs143691643	A>T	A:421	(10.41, 4.59, 20.69)
9:140006149		G>E	A:422	(10.99, 7.72, 22.19)
9:140006147		G>C	A:423	(12.87, 8.82, 19.55)
9:140005398	COSM291553	R>Q	A:426	(5.22, 7.01, 19.23)
9:140005399	rs149094336	R>W	A:426	(5.22, 7.01, 19.23)
9:140005395		R>K	A:427	(1.93, 10.35, 15.71)
9:140005389	COSM1204503	L>P	A:429	(2.53, 13.90, 11.48)
9:140005383	rs117203759	A>V	A:431	(-2.57, 11.57, 5.60)
9:140005384		A>T	A:431	(-2.57, 11.57, 5.60)
9:140005381	rs201939351	S>P	A:432	(0.92, 10.47, 4.18)
9:140005372		A>T	A:435	(2.02, 6.00, 13.01)
9:140005350		A>V	A:442	(10.72, -4.44, 19.85)
9:140005347		H>R	A:443	(14.64, -2.36, 17.23)
9:140005339	rs368784110	D>N	A:446	(7.83, -4.49, 11.60)
9:140005230		S>C	A:450	(6.04, -14.06, 9.57)
9:140005225	rs139799228	P>A	A:452	(4.21, -18.62, 14.49)
9:140005219	rs145975183	D>N	A:454	(4.15, -13.07, 15.75)
9:140005206	rs370575983	V>A	A:458	(2.98, -7.47, 14.39)
9:140005207	rs142555506	V>M	A:458	(2.98, -7.47, 14.39)
9:140005201		E>K	A:460	(-2.97, -5.88, 13.75)
9:140005197	rs201321992	A>V	A:461	(1.05, -3.78, 11.50)
9:140005194	rs374355556 COSM1165451	R>Q	A:462	(3.80, -7.44, 9.74)
9:140005177		I>V	A:468	(-0.22, 2.08, 3.25)
9:140005173		I>S	A:469	(3.27, -0.17, 0.68)
9:140005168	rs199703007 COSM3905969	E>K	A:471	(-1.65, 2.56, -2.11)
9:140005146	rs376671686	R>H	A:478	(-1.53, 6.52, -11.92)
9:140005147	rs144785203	R>C	A:478	(-1.53, 6.52, -11.92)

3JYH.A | DPP7.

3JYH.A | DPP7

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:140008935	COSM3699583	P>H	A:54	(33.35, -0.85, -4.84)
9:140008819	COSM4533427	R>Q	A:66	(10.62, -8.29, -15.71)
9:140008750	COSM3763813	A>G	A:89	(11.54, -10.80, 5.75)
9:140008443	COSM3699582	S>F	A:120	(38.09, 3.23, 5.35)
9:140007875	COSM1107042	A>T	A:187	(13.19, 5.58, 13.50)
9:140007473	COSM1250660	V>M	A:268	(20.81, -6.09, 23.79)