Assessment of Structural Intolerance and Durability
General Structure Information 1fo3 MAN1B1 crystal structure of human class i alpha1,2-mannosidase in complex with kifunensine 1.75Å AUTH F.VALLEE,K.KARAVEG,A.HERSCOVICS,K.W.MOREMEN,AUTH 2 P.L.HOWELLTITL STRUCTURAL BASIS FOR CATALYSIS AND INHIBITION OFTITL 2 N-GLYCAN PROCESSING CLASS I ALPHA 1,2-MANNOSIDASES.REF J.BIOL.CHEM. V. 275 41287 2000REFN ISSN 0021-9258PMID 10995765DOI 10.1074/JBC.M006927200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3i3t USP21 crystal structure of covalent ubiquitin-usp21 complex 2.59Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3p1j GIMAP2 crystal structure of human gtpase imap family member 2 in the nucleotide-free state 2.58Å AUTH L.SHEN,W.TEMPEL,Y.TONG,X.GUAN,L.NEDYALKOVA,A.K.WERNIMONT,AUTH 2 F.MACKENZIE,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,D.W.ANDREWS,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN GTPASE IMAP FAMILY MEMBER 2 INTITL 2 THE NUCLEOTIDE-FREE STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2qq8 TBC1D14 crystal structure of the putative rabgap domain of human tbc1 domain family member 14 2.0Å AUTH Y.TONG,W.TEMPEL,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OFTITL 2 HUMAN TBC1 DOMAIN FAMILY MEMBER 14.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3vfd SPAST human spastin aaa domain 3.3Å AUTH J.L.TAYLOR,S.R.WHITE,B.LAURING,F.J.KULLTITL CRYSTAL STRUCTURE OF THE HUMAN SPASTIN AAA DOMAIN.REF J.STRUCT.BIOL. V. 179 133 2012REFN ISSN 1047-8477PMID 22446388DOI 10.1016/J.JSB.2012.03.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4c0d CNOT2 structure of the not module of the human ccr4-not complex (cnot1-cnot2-cnot3) 3.2Å AUTH A.BOLAND,Y.CHEN,T.RAISCH,S.JONAS,D.KUZUOGLU-OZTURK,AUTH 2 L.WOHLBOLD,O.WEICHENRIEDER,E.IZAURRALDETITL STRUCTURE AND ASSEMBLY OF THE NOT MODULE OF THE HUMANTITL 2 CCR4-NOT COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1289 2013REFN ISSN 1545-9993PMID 24121232DOI 10.1038/NSMB.2681 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3a8y BAG5 crystal structure of the complex between the bag5 bd5 and hsp70 nbd 2.3Å AUTH A.ARAKAWA,N.HANDA,N.OHSAWA,M.SHIDA,T.KIGAWA,AUTH 2 F.HAYASHI,M.SHIROUZU,S.YOKOYAMATITL THE C-TERMINAL BAG DOMAIN OF BAG5 INDUCESTITL 2 CONFORMATIONAL CHANGES OF THE HSP70TITL 3 NUCLEOTIDE-BINDING DOMAIN FOR ADP-ATP EXCHANGEREF STRUCTURE V. 18 309 2010REFN ISSN 0969-2126PMID 20223214DOI 10.1016/J.STR.2010.01.004 Variant Set Distributions Mapped Variants
General Structure Information 1pja PPT2 the crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (ppt1 and ppt2) 2.7Å AUTH G.CALERO,P.GUPTA,M.C.NONATO,S.TANDEL,E.R.BIEHL,S.L.HOFMANN,AUTH 2 J.CLARDYTITL THE CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE-2TITL 2 (PPT2) REVEALS THE BASIS FOR DIVERGENT SUBSTRATETITL 3 SPECIFICITIES OF THE TWO LYSOSOMAL THIOESTERASES, PPT1 […]
General Structure Information 2m3d DDX21 nmr structure of the guct domain from human dead box polypeptide 21 -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICHTITL NMR STRUCTURE OF THE GUCT DOMAIN FROM HUMAN DEAD BOXTITL 2 POLYPEPTIDE 21 (DDX21)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants